4578 Background: The electrocardiographic QT interval measures ventricular repolarization, and, if prolonged, may predispose to arrhythmias and sudden death. Preclinically, testosterone (T) deficiency may prolong the QT interval. However, the effect of hormone treatments (HTs) for prostate cancer which induce androgen deficiency (AD) has not been well studied. METHODS Three randomized Phase III studies were conducted that compared the GnRH antagonist abarelix to either goserelin plus bicalutamide (G+B) (Study 1); leuprolide (L) monotherapy (Study 2; Urology 58:756, 2001); or L plus B (L+B) (Study 3; J. Urol 167:1670, 2002) in patients (pts) with prostate cancer undergoing initial HT and included pts with Stage D1/D2 disease, rising PSA, intermittent HT or neoadjuvant HT. Study 1 prospectively evaluated data from 177 pts; Studies 2 and 3 retrospectively evaluated 299 of 520 treated pts. Barzett and Fredericia QT intervals (QTcB, QTcF) were measured at baseline (BL), days(D) 84 and 336 of treatment in Study 1; and at BL and D 169 in Studies 2 and 3. RESULTS [Formula: see text] (ng/mL) at BL, D 85 and 336 in Study 1: G+B: 347; 23; 26, respectively; abarelix: 316, 23, 35. In Studies 2 and 3, T levels at BL and D169: L: 342, 9; L+B: 358, 13; abarelix (pooled): 361,14, respectively. [Formula: see text] at BL and median change from BL on study are: Study 1: G+B: 402, +18; abarelix: 407, +13 (p=0.018 t-test; 0.015 Wilcoxon rank sum). Study 2 and 3: L: 413, +21; L+B: 417, +9; abarelix: 410, +12 (p values from pairwise comparisons, all NS). [Formula: see text]: Study 1: G+B: 46%; abarelix: 39%; Studies 2 and 3: L: 27%; L+B: 26%; abarelix: 17%. [Formula: see text] Study 1: G+B: 8%; abarelix: 2%; Studies 2 and 3: L: 6%; L+B: 0%; abarelix: 4%. CONCLUSIONS HTs which induce AD are all associated with prolongation of the QT interval. These findings should be considered in assessing the risk and benefit of HT, especially in those with BL QT values of >450 msec and who are taking Class IA or III antiarrhythmics. [Table: see text].

the CPR for those with a score that was >2 was 20%.These differences were not statistically significant.There was a trend towards a lower pregnancy rate in patients aged >35, those with endometriosis, those who underwent 01, and patients having higher Kerin and Brosen scores, although these differences did not reach statistical significance (P values = 0.67, 0.66).Kerin and Brosen scores were highly correlated (Spearman rank correlation, I = 0.81).Conclusions: Both salpingoscopic scoring systems showed a high correlation with one another.As a result, adoption of a universally accepted scoring system should be easily achieved.A diagnosis of endometriosis and higher salpingoscopy scores were associated with lower pregnancy rates.PI1 SO015

Prostate and bladder carcinoma are, in large part, diseases of older adults, and they are discussed in this context. Pathology, diagnosis, and staging are reviewed. Surgical and medical approaches to these malignancies, and the limitations of these approaches, are highlighted. Renal cell carcinoma, while a relatively rare neoplasm, remains a formidable challenge: approximately 50% of patients die within 5 years of diagnosis. Advances in molecular genetics and histopathologic classification, as well as surgical management and investigational therapies, are emphasized.