Introduction: Aortoduodenal syndrome is exceedingly rare and characterized by duodenal obstruction from a large abdominal aortic aneurysm. Traditionally, treatment is by open aneurysm repair, aneurysmorraphy, and duodenal release. This approach carries a significant mortality. Endovascular aneurysm repair has not been used before in this condition as it was felt that the duodenal obstruction would still require surgical decompression. Report: We report two patients with aortoduodenal syndrome successfully treated by endovascular stent graft alone. Discussion: The pathophysiology of this syndrome is reviewed and a new hypothesis of a dynamic element in aortoduodenal syndrome presented. Endovascular Management of Aortoduodenal Syndrome: A Novel Treatment for a Rare ConditionEJVES ExtraVol. 27Issue 3PreviewAortoduodenal syndrome is exceedingly rare and characterized by duodenal obstruction from a large abdominal aortic aneurysm. Traditionally, treatment is by open aneurysm repair, aneurysmorraphy, and duodenal release. This approach carries a significant mortality. Endovascular aneurysm repair has not been used before in this condition as it was felt that the duodenal obstruction would still require surgical decompression. Full-Text PDF Open Access