Hepatic and celiac vagotomy in dogs does not alter the volume and motility of the gallbladder after 10 weeks. However, hepatic and celiac vagotomy results in less secretion of bilirubin and neutral red in bile and decreased concentration of radiologic contrast material in the gallbladder.

Amdrup, B. M. & Griffith, C. A. 1970. The Effect of Insulin upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass. Scand. J. Gastroent. 5, 655-665.The study concerns Heidenhain pouch dogs which had undergone selective vagotomy of the parietal cell mass or selective vagotomy plus suprapyloric antrectomy. Other dogs which had undergone appropriate operations were used as comparative controls. Feeding responses alone, and feeding responses in the presence of insulin hypoglycaemia were compared. In the selective vagotomy dogs insulin stimulation of acid secretion was preceded by inhibition. Insulin’s stimulatory effect was reduced in dogs with additional suprapyloric antrectomy. Results suggest that the gastric vagi may sensitise the antral gastrin producing apparatus. Extragastric vagi may in some way inhibit gastric secretion.

Amdrup, B. M. & Griffith, C. A. 1970. The Effect of a Ganglion-blocking Agent (Hexamethonium Bromide) upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass. Scand. J. Gastroent. 5, 667-674.Feeding response in Heidenhain pouch dogs with selective vagotomy of the parietal cell mass with and without suprapyloric antrectomy was compared to feeding response during treatment with hexamethonium bromide. The effect of hexamethonium was initial inhibiton of pouch secretion, followed by delayed hypersecretion. The inhibition may result from blockage of vagal stimulation of the antrum. The reason for the delayed hypersecretion is discussed.