Letters1 January 1976Allergic Rash Due to Amphotericin BBENNETT LORBER, M.D., CHARLES CUTLER, M.D., WILLIAM E. BARRY, M.D.BENNETT LORBER, M.D.Search for more papers by this author, CHARLES CUTLER, M.D.Search for more papers by this author, WILLIAM E. BARRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-54 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdverse reactions to the widely used antifungal agent, amphotericin B, are frequent and include fever, chills, nausea, vomiting, phlebitis, azotemia, hypokalemia, and anemia (1, 2). However, it has been stated (2) that allergic reactions are "so rare as to cast doubt on their relation to amphotericin B." We report a case in which a generalized pruritic maculopapular rash and eosinophilia were apparently manifestations of hypersensitivity to amphotericin B.A 55-year old white man, with a past history of pulmonary tuberculosis was admitted to Temple University Hospital on 12 April 1975 for evaluation of fever and anemia. Three months before admission,...References1. UTZBENNETTBRANDRISS JJM: Amphotericin B toxicity. Combined clinical staff conference at the National Institutes of Health. Ann Intern Med 61:334-354, 1964 LinkGoogle Scholar2. BENNETT J: Chemotherapy of systemic mycoses. N Engl J Med 290:30-32, 320-323, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Infectious Diseases and Section of Hematology Department of Medicine Temple University Health Sciences Center Philadelphia, Pennsylvania 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-Induced EosinophiliaIs Amphotericin B Test Dosing Needed?Update on Invasive CandidiasisEosinophilia and Allergic Reactions to DrugsAntifungal drugs 1 January 1976Volume 84, Issue 1Page: 54-54KeywordsAllergy and immunologyAmphotericinAnemiaAntifungalsEosinophiliaFeversHypersensitivityNauseaRashesVomiting Issue Published: 1 January 1976 PDF DownloadLoading ...

BODY IRON IN MAN is estimated at 35 to 45 mg/kg or a total of about 3 g.1 The major portion of body iron, some 30 mg/kg, is held in the circulating red cell mass and erythroid marrow as hemoglobin. The only other fraction of quantitative significance is storage iron, amounting to another 15 mg/kg in the adult male and varying from 0 to 10 mg/kg in the female. The manner in which body iron is maintained and its movement within the body become important in understanding anemia and iron overload states. For the purposes of this discussion, three aspects of iron exchange will be considered: exchange between man and his environment, internal iron exchange and, more specifically, storage iron exchange.

Inadequate hemoglobin production, characteristically associated with iron-deficiency anemia, may also occur in a variety of clinical disorders which manifest defective iron utilization rather than lack of iron. Defects may involve (1) plasma iron transport (deficiency of transferrin, anemia of infection), (2) intramedullary iron transport (chloramphenicol toxicity) or (3) hemoglobin synthesis (pyridoxine-responsive anemia, thalassemia, lead poisoning, hypochromic iron-loading anemia). Differentiation of true iron-deficiency anemia from defective iron utilization depends primarily on assessment of iron stores by determination of the level of serum iron and iron-binding protein, determination of stainable bone marrow iron, and occasionally a therapeutic trial of parenteral iron.