Bassem Hammami | AMiner学者主页

The aim of this study was to assess the impact of Ramadan intermittent fasting on metabolic and inflammatory profiles in type 2 diabetic patients (T2D). It was a prospective study including 55 T2D patients treated with oral hypoglycemic drugs, who intended to observe Ramadan fasting in 2019. All participants underwent a questionnaire, a physical examination, laboratory investigations, and a cardiovascular risk assessment using the Framingham score before Ramadan (T0), immediately after Ramadan (T1), and two months after Ramadan (T2). The mean age of participants was 54.5 ± 10.1 years. The number of fasted days was 29.3 ± 2.3 days. The mean total daily calorie intake decreased significantly by 19% during Ramadan (p < 10–3). A significant decrease in weight (79.8 ± 12.9 vs 78.4 ± 13.3 kg, p = 0.003), body mass index (29.8 ± 5.4 vs 29.2 ± 5.4 kg/m2, p = 0.004), waist circumference (98.2 ± 9.6 vs 96.3 ± 10.2 cm, p = 0.015), fat body mass (24.3 ± 9.4 vs 23.5 ± 9.7 kg, p = 0.043) was observed at T1. The weight loss was significantly correlated with the number of fasting days (r = 0.348, p = 0.009) and was maintained at T2. Serum fructosamine increased at T1 (303.6 ± 46 vs 333.49 ± 59.49 µmol/L, p < 10–3) and returned to its baseline levels at T2. A significant decrease in insulin (9.7 ± 5.5 vs 7.98 ± 5.05 mIU/L, p = 0.043), fibrinogen (3.7 ± 0.8 vs 3.4 ± 0.6 g/L, p = 0.003), and hs-CRP (4.8 ± 5.7 vs 3.7 ± 4.5 mg/L, p = 0.058) levels was observed at T1. Homocysteine level was significantly higher after Ramadan (12.2 ± 6.2 vs 13.5 ± 6.4 µmol/L, p = 0.001). However, no significant changes were found in blood pressure, fasting blood glucose, HOMA-IR, uric acid, lipids, and white blood cells count. The mean Framingham score decreased insignificantly after Ramadan. Ramadan fasting in T2D patients seems to have a favorable impact on anthropometric parameters and inflammatory profile. However, it may cause a transient worsening of glycemic control.

2022Journal of Diabetes & Metabolic Disorders（2022）引用：4

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6Assessment of a New Marker of Polycystic Ovary Syndrome in Morbidly Obese Women

Ibtissem Oueslati,Amani Terzi,Bassem Hammami,Hana Belhadj Hassen,Seif Boukriba,Habiba Mizouni,Moncef Feki,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2022Endocrine Abstracts（2022）

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7Toxicological Evaluation of Oral Exposure to Isoniazid: Behavioral, Biochemical, and Histopathological Assessments in Rats

Dorra Ben Said,Israa Dahmani,Ridha Ben Ali,Hammami Bassem, Moncef El Fekih,Achraf Chedly, Michelle-Veronique Elmay,Emna Gaies,Sihem El Aidli

Isoniazid (INH), being the first-line drug used as an anti-tuberculosis drug, is known to be associated with physiological deteriorations including hepatic and neurologic disturbances. This study was aimed at biochemical and behavioral characterization of toxic manifestations of isoniazid treatment in Wistar rats. Experimental animals were divided into four groups. Each group consists of six animals including the control group (saline solution), I25 group (25 mg/kg of INH), I50 group (50 mg/kg of INH), and I100 group (100 mg/kg of INH). Animals received daily INH for 30 days. Isoniazid is known to be associated with hepatotoxicity; it's among the most common causes of drug-induced toxicities. For this reason assays for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were performed to assess liver toxicity. Moreover, behavioral study, renal, and lipid parameters were also assessed in addition to histological features of the liver and brain. Significant differences in all studied parameters were seen especially in the I100 group and a marked increase in liver enzymes activities, such as AST and ALT was observed. In another hand, there were no major clinical signs in treated animals, except fatigue and anxiety in the I100 group. On the other hand, the histological findings showed potential liver and brain injury which was evidenced by degenerative changes, infiltration, and hepatocyte necrosis, in addition to the appearance of many pyramidales cells in the gyrus. The current study findings suggest that INH interacts with multiple biochemical pathways in the body what comes up by behavioral changes and liver disturbances in animals caused by INH toxicity.

2021Drug and Chemical Toxicology（2021）

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8Visceral Adiposity Index and Atherogenic Index of Plasma: Simple Markers of Insulin Resistance in Type 2 Diabetic Patients

Asma Kardi,Ibtissem Oueslati,Meriem Yazidi,Bassem Hammami,Fatma Boukhayatia,Fatma Chaker,Moncef Feki,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2021Endocrine Abstracts（2021）

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9Metabolic and Cardiovascular Consequences of Ramadan Fasting in Type 2 Diabetic Patients

Fatma Boukhayatia,Ibtissem Oueslati, Meriem Cheikh,Bassem Hammami,Asma Kardi,Meriem Yazidi,Moncef Feki,Neila Ben Romdhane,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2020Endocrine Abstracts（2020）

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10Effets Du Jeûne Du Mois De Ramadan Sur Le Statut Inflammatoire Chez Le Diabétique De Type 2.

Fatma Boukhayatia,Ibtissem Oueslati,Bassem Hammami,Asma Kardi, M. Ben Cheikh,Neïla Ben Romdhane,Moncef Feki,Mélika Chihaoui

2020

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11Diagnostic Value of Anti Mullerian Hormone for Detecting Polycystic Ovary Syndrome in Tunisian Morbidly Obese Women

Rym Belaid,Ibtissem Oueslati, Hana BelhadjHassen,Bassem Hammami,Seif Boukriba,Meriem Yazidi,Wafa Grira,Fatma Chaker,Habiba Mizouni,Moncef Feki,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2020Endocrine Abstracts

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12Insulin Resistance and Metabolic Disorders in Women with Morbid Obesity

Fatma Boukhayatia,Ibtissem Oueslati,Hana Belhadj Hassen,Bassem Hammami,Wafa Grira,Moncef Feki,Fatma Chaker,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2019Endocrine Abstracts（2019）

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13Ovarian Ultrasound Features in Women with Morbid Obesity

Rym Belaid,Ibtissem Oueslati, HadjHassen Hana Ben,Seif Boukriba,Bassem Hammami,Fatma Chaker,Habiba Mizouni,Moncef Feki,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2019Endocrine Abstracts（2019）

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14Predictive Factors of Polycystic Ovary Syndrome in Women with Morbid Obesity

Rym Belaid, Hana Ben Hadj Hassen,Ibtissem Oueslati,Bassem Hammami,Seif Boukriba,Ons Rejeb,Wafa Grira,Habiba Mizouni,Moncef Feki,Fatma Chaker,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2019Endocrine Abstracts

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15Reproductive Disorders in Women with Morbid Obesity

Rym Belaid, Hadj Hassen Hana Ben,Ibtissem Oueslati,Bassem Hammami,Seif Boukriba,Meriem Yazidi,Moncef Feki,Habiba Mizouni,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2019Endocrine Abstracts（2019）

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16Prevalence of Non Alcoholic Fatty Liver Disease in Women with Morbid Obesity

Fatma Boukhayatia,Ibtissem Oueslati,Hana Belhadj Hassen,Bassem Hammami,Seif Boukriba,Fatma Chaker,Meriem Yazidi,Habiba Mizouni,Melika Chihaoui

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

2019Endocrine Abstracts（2019）

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17Vitamin A, E, B-12, and Folic Acid in End-Stage Renal Disease Tunisian Patients: Status and Predictive Value for Overall Mortality and Cardiovascular Events

Hayet Fellah,Moncef Feki,Sameh Hadj Taieb,Bassem Hammami,Karima Boubaker,Bernard Lacour,Taieb Ben Abdallah,Naziha Kaabachi

BACKGROUND Vitamin status and role in end stage renal disease (ESRD) is controversial. This study was aimed at assessing vitamin A, E, B12, and folic acid status in Tunisian ESRD patients and testing their predictive value for overall mortality and cardiovascular events (CVE). METHODS We examined plasma vitamin A, E, B12, and folic acid in 115 ESRD patients and looked for any correlation with all-cause mortality and CVE after a six year follow-up. Vitamin A and E were determined by HPLC and vitamin B12 and folic acid were determined by enzyme immunoassay. RESULTS At enrolment, plasma vitamin A was higher in patients than controls, while plasma vitamin B12 was higher in HD patients. No significant differences were observed for plasma vitamin E and folic acid concentrations between patients and controls. Folic acid and vitamin B12 levels were higher in supplemented patients. During the follow-up period, 17 patients were lost, 15 died, and 36 presented a CVE. Survival analysis showed that mortality and/or CVE trend to be lower for high folic acid levels (Log Rank = 0.098). Cox's regression analysis showed that high levels of folic acid are inversely related to all-cause mortality and/or CVE [Hazard ratio (95% confidence interval), 0.255 (0.08 - 0.740); p = 0.012]. CONCLUSIONS Plasma vitamins A, E, B12, and folic acid concentrations are usually normal in Tunisian ESRD patients. High folic acid levels are associated with fewer CVE and better survival. However, as uremia could be associated with functional vitamin deficiency, maintaining high plasma vitamin levels by adequate nutrition and tolerable supplementation would be beneficial in ESRD patients.

2011Clinical laboratory（2011）引用：27

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