Ketoconazole was used to probe the pathogenetic importance of the serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentration in 19 patients with well characterized absorptive hypercalciuria (AH). Patients were studied while receiving a constant metabolic diet before and after 2 weeks of ketoconazole administration (600 mg daily). Twelve of the patients were classified as ketoconazole responders, because in conjunction with a reduction of serum 1,25-(OH)2D from 113 +/- 36 to 70 +/- 26 pmol/L, intestinal 47Ca absorption decreased from 76.3 +/- 8.1% to 61.9 +/- 7.7%, and 24-h urinary Ca excretion declined from 7.6 +/- 1.4 to 5.7 +/- 1.1 mmol (P < 0.001 each). In these patients, intestinal 47Ca absorption was directly correlated with serum 1,25-(OH)2D levels and 24-h Ca excretion. In another group of 7 patients, termed ketoconazole nonresponders, despite reduction of 1,25-(OH)2D from 122 +/- 36 to 84 +/- 17 pmol/L (P = 0.015), there was no significant change in intestinal Ca absorption (76.0 +/- 8.2% to 72.1 +/- 10.6%) or 24-h urinary Ca excretion (7.3 +/- 1.3 to 7.2 +/- 1.0 mmol). In these patients, neither intestinal Ca absorption nor urinary Ca excretion was correlated with serum 1,25-(OH)2D levels. It, thus, appears that AH is a heterogeneous disorder comprised of both vitamin D-dependent and vitamin D-independent subsets. Although useful to probe the pathogenesis of AH, chronic treatment with ketoconazole is not recommended because of its generalized effects in inhibiting steroid synthesis.

HomeHypertensionVol. 4, No. 5Urinary excretion of prostaglandin E2, prostaglandin F2 alpha, and thromboxane B2 in normotensive and hypertensive subjects on varying sodium intakes. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBUrinary excretion of prostaglandin E2, prostaglandin F2 alpha, and thromboxane B2 in normotensive and hypertensive subjects on varying sodium intakes. W B Campbell, O B Holland, B V Adams and C E Gomez-Sanchez W B CampbellW B Campbell , O B HollandO B Holland , B V AdamsB V Adams and C E Gomez-SanchezC E Gomez-Sanchez Originally published1 Sep 1982https://doi.org/10.1161/01.HYP.4.5.735Hypertension. 1982;4:735–741 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Biringer R (2020) The enzymology of the human prostanoid pathway, Molecular Biology Reports, 10.1007/s11033-020-05526-z, 47:6, (4569-4586), Online publication date: 1-Jun-2020. Fu J, Schoeman J, Harms A, van Wietmarschen H, Vreeken R, Berger R, Cuppen B, Lafeber F, van der Greef J and Hankemeier T (2016) Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis, Analytical and Bioanalytical Chemistry, 10.1007/s00216-016-9742-2, 408:23, (6307-6319), Online publication date: 1-Sep-2016. 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Yao S, Ober J, McNatt J, Benedict C, Rosolowsky M, Anderson H, Cui K, Maffrand J, Campbell W and Buja L (1992) ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries., Circulation Research, 70:1, (39-48), Online publication date: 1-Jan-1992. Klemm S, Hornych A, Tunny T and Gordon R (1991) THE SYNDROME OF HYPERTENSION AND HYPERKALAEMIA WITH NORMAL GLOMERULAR FILTRATION RATE: IS THERE A DEFICIENCY IN VASODILATOR PROSTAGLANDINS?, Clinical and Experimental Pharmacology and Physiology, 10.1111/j.1440-1681.1991.tb01452.x, 18:5, (309-313), Online publication date: 1-May-1991. Roman R and Lianos E (1990) Influence of prostaglandins on papillary blood flow and pressure-natriuretic response., Hypertension, 15:1, (29-35), Online publication date: 1-Jan-1990.Minuz P, Barrow S, Cockcroft J and Ritter J (1990) Prostacyclin and thromboxane biosynthesis in mild essential hypertension., Hypertension, 15:5, (469-474), Online publication date: 1-May-1990. Yao S, Rosolowsky M, Anderson H, Golino P, NcNatt J, de Clerck F, Buja L and Willerson J (1990) Combined thromboxane A2synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations, Journal of the American College of Cardiology, 10.1016/0735-1097(90)90363-T, 16:3, (705-713), Online publication date: 1-Sep-1990. Judd J, Marshall M and Dupont J (1989) Relationship of dietary fat to plasma fatty acids, blood pressure, and urinary eicosanoids in adult men., Journal of the American College of Nutrition, 10.1080/07315724.1989.10720313, 8:5, (386-399), Online publication date: 1-Oct-1989. Lebel M, Grose J and Falardeau P (1989) Modulation of renal hemodynamics by renal eicosanoids during vasopressor infusions in man, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 10.1016/0952-3278(89)90015-X, 35:1, (41-49), Online publication date: 1-Jan-1989. Steinhelper M, Fisher R, Revtyak G, Hanahan D and Olson M (1989) β2-Adrenergic Agonist Regulation of Immune Aggregate- and Platelet-activating Factor-stimulated Hepatic Metabolism, Journal of Biological Chemistry, 10.1016/S0021-9258(18)60414-4, 264:19, (10976-10981), Online publication date: 1-Jul-1989. Gauntt C, Godeny E, Lutton C, Arizpe H, Crapman N, Tracy S, Revtyak G, Valente A and Rozek M (1989) Mechanism(S) of Coxsackievirus-Induced Acute Myocarditis in the Mouse Medical Virology 8, 10.1007/978-1-4899-0891-9_10, (161-182), . Kudo K, Abe K, Chiba S, Sato M, Yasujima M, Kohzuki M, Omata K, Tanno M, Tsunoda K and Yoshinaga K (1988) Role of thromboxane A2 in the hypotensive effect of captopril in essential hypertension., Hypertension, 11:2, (147-152), Online publication date: 1-Feb-1988.Reid G, Appel R and Dunn M (1988) Papillary collecting tubule synthesis of prostaglandin E2 in Dahl rats., Hypertension, 11:2, (179-184), Online publication date: 1-Feb-1988.Mistry M and Nasjletti A (1988) Role of pressor prostanoids in rats with angiotensin II-salt-induced hypertension., Hypertension, 11:6_pt_2, (758-762), Online publication date: 1-Jun-1988.Sowers J, Zemel M, Zemel P, Beck F, Walsh M and Zawada E (1988) Salt sensitivity in blacks. Salt intake and natriuretic substances., Hypertension, 12:5, (485-490), Online publication date: 1-Nov-1988. Revtyak G, Johnson A and Campbell W (1988) Cultured bovine coronary arterial endothelial cells synthesize HETEs and prostacyclin, American Journal of Physiology-Cell Physiology, 10.1152/ajpcell.1988.254.1.C8, 254:1, (C8-C19), Online publication date: 1-Jan-1988. Nasjletti A and Baer P (1988) Prostanoids in clinical and experimental hypertension Eicosanoids in the Cardiovascular and Renal Systems, 10.1007/978-94-009-1285-4_7, (159-175), . Gauntt C, Lutton C, Revtyak G, Valente A, Fernandes A, Arizpe H and Rozek M (1988) Induction of Soluble Mediators During Coxsackievirus B3 Replication In Vitro and In Vivo New Concepts in Viral Heart Disease, 10.1007/978-3-642-73610-0_9, (93-104), . Chi M and Hawkins K (1988) Effects of dietary sodium intake on blood pressure and urinary excretion of prostaglandins in normotensive and hypertensive subjects, Nutrition Research, 10.1016/S0271-5317(05)80086-7, 8:11, (1237-1249), Online publication date: 1-Nov-1988. Campbell W and Ojeda S (1987) Measurement of prostaglandins by radioimmunoassay Cellular Regulators Part B: Calcium and Lipids, 10.1016/0076-6879(87)41080-X, (323-341), . Revtyak G, Johnson A and Campbell W (1987) Prostaglandin synthesis in bovine coronary endothelial cells: comparison with other commonly studied endothelial cells, Thrombosis Research, 10.1016/0049-3848(87)90433-6, 48:6, (671-683), Online publication date: 1-Dec-1987. Ruddy M and Barone J (1986) Medical Treatment of Renal Hypertension Hypertension in Kidney Disease, 10.1007/978-94-009-4271-4_8, (171-249), . Callahan K, Johnson A and Campbell W (1985) Enhancement of the antiaggregatory activity of prostacyclin by propranolol in human platelets., Circulation, 71:6, (1237-1246), Online publication date: 1-Jun-1985. Wilcox C, Roddis S, Stanley Peart W, Gordon D and Lewis G (1985) Intrarenal prostaglandin release: Effects of arachidonic acid and hyperchloremia, Kidney International, 10.1038/ki.1985.116, 28:1, (43-50), Online publication date: 1-Jul-1985. Craig Brater D, Anderson S, Baird B and Campbell W (1985) Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men, Kidney International, 10.1038/ki.1985.11, 27:1, (66-73), Online publication date: 1-Jan-1985. Favreä L, Jornot L, Riondel A and Vallotton M (2009) Urinary Excretion of Renal Prostaglandins, Kallikrein, Vasopressin and Aldosterone in Essential Hypertension, Clinical and Experimental Hypertension. Part A: Theory and Practice, 10.3109/10641968509073617, 7:12, (1663-1679), Online publication date: 1-Jan-1985. Smith M and Dunn M (1985) The Role of Prostaglandins in Human Hypertension, American Journal of Kidney Diseases, 10.1016/S0272-6386(85)80063-9, 5:4, (A32-A39), Online publication date: 1-Apr-1985. Campbell W, Falck J, Okita J, Johnson A and Callahan K (1985) Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 10.1016/0005-2760(85)90086-4, 837:1, (67-76), Online publication date: 1-Oct-1985. Bush L, Campbell W, Buja L, Tilton G and Willerson J (1984) Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries., Circulation, 69:6, (1161-1170), Online publication date: 1-Jun-1984. Gotah S, Ogihara T, Tabuchi Y and Kimiahara Y (1984) PGE2, 6-O-PGF1α and sodium balance in essential hypertensive patients, Prostaglandins, Leukotrienes and Medicine, 10.1016/0262-1746(84)90129-X, 15:3, (293-301), Online publication date: 1-Sep-1984. Chiba S, Abe K, Kudo K, Omata K, Yasujima M, Sato K, Seino M, Imai Y, Sato M and Yoshinaga K (1984) Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: A possible pathophysiological role of TXA2 in the aged kidney, Prostaglandins, Leukotrienes and Medicine, 10.1016/0262-1746(84)90191-4, 16:3, (347-358), Online publication date: 1-Dec-1984. Henrich W and Campbell W (1984) Relationship between PG and beta-adrenergic pathways to renin release in rat renal cortical slices, American Journal of Physiology-Endocrinology and Metabolism, 10.1152/ajpendo.1984.247.3.E343, 247:3, (E343-E348), Online publication date: 1-Sep-1984. Scherer B, Witzgall H and Weber P (1984) Prostaglandin excretion after furosemide in normal and low-renin essential hypertension, Klinische Wochenschrift, 10.1007/BF01721777, 62:16, (777-782), Online publication date: 1-Aug-1984. Sullivan J and McGiff J (1984) Kallikrein-Kinin- und Prostaglandin-Systeme bei Hypertonie Arterielle Hypertonie, 10.1007/978-3-662-00760-0_15, (254-280), . Holland O, von Kuhnert L, Campbell W and Anderson R (1983) Synergistic effect of captopril with hydrochlorothiazide for the treatment of low-renin hypertensive black patients., Hypertension, 5:2, (235-239), Online publication date: 1-Mar-1983. September 1982Vol 4, Issue 5 Advertisement Article InformationMetrics Copyright © 1982 by American Heart Associationhttps://doi.org/10.1161/01.HYP.4.5.735PMID: 7049923 Originally publishedSeptember 1, 1982 PDF download Advertisement

HomeHypertensionVol. 2, No. 4Role of prostaglandins in angiotensin-induced steriodogenesis absence of an effect by prostaglandin E2. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBRole of prostaglandins in angiotensin-induced steriodogenesis absence of an effect by prostaglandin E2. W B Campbell, C E Gomez-Sanchez and B V Adams W B CampbellW B Campbell , C E Gomez-SanchezC E Gomez-Sanchez and B V AdamsB V Adams Originally published1 Jul 1980https://doi.org/10.1161/01.HYP.2.4.471Hypertension. 1980;2:471–476 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Ganguly A (2000) Aldosterone Comprehensive Physiology, 10.1002/cphy.cp070305, (156-227), Online publication date: 1-Dec-2000. Gauntt C, Godeny E, Lutton C, Arizpe H, Crapman N, Tracy S, Revtyak G, Valente A and Rozek M (1989) Mechanism(S) of Coxsackievirus-Induced Acute Myocarditis in the Mouse Medical Virology 8, 10.1007/978-1-4899-0891-9_10, (161-182), . Richards C and Campbell W (1989) Incorporation of hydroxyeicosatetraenoic acids into cellular lipips of adrenal glomerulosa cells: Inhibition of aldosterone release by 5-HETE, Prostaglandins, 10.1016/0090-6980(89)90150-0, 38:5, (565-580), Online publication date: 1-Nov-1989. Gauntt C, Lutton C, Revtyak G, Valente A, Fernandes A, Arizpe H and Rozek M (1988) Induction of Soluble Mediators During Coxsackievirus B3 Replication In Vitro and In Vivo New Concepts in Viral Heart Disease, 10.1007/978-3-642-73610-0_9, (93-104), . Redfern J, Lee E and Feldman M (1987) Effect of Indomethacin on Gastric Mucosal Prostaglandins in Humans, Gastroenterology, 10.1016/0016-5085(87)90972-3, 92:4, (969-977), Online publication date: 1-Apr-1987. Ashton J, Schmitz J, Campbell W, Ogletree M, Raheja S, Taylor A, Fitzgerald C, Buja L and Willerson J (1986) Inhibition of cyclic flow variations in stenosed canine coronary arteries by thromboxane A2/prostaglandin H2 receptor antagonists., Circulation Research, 59:5, (568-578), Online publication date: 1-Nov-1986. Campbell W, Brady M and Gomez-Sanchez C (1986) Effects of angiotensin, prostaglandin e2 and indomethacin on the early and late steps of aldosterone biosynthesis in isolated adrenal cells, Journal of Steroid Biochemistry, 10.1016/0022-4731(86)90447-4, 24:4, (865-870), Online publication date: 1-Apr-1986. Bush L and Patrick D (1986) The role of the endothelium in arterial thrombosis and the influence of antithrombotic therapy, Drug Development Research, 10.1002/ddr.430070405, 7:4, (319-340), Online publication date: 1-Apr-1986. Richards C, Johnson A and Campbell W (1986) Specific incorporation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid into phosphatidylcholine in human endothelial cells, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 10.1016/0005-2760(86)90079-2, 875:3, (569-581), Online publication date: 1-Feb-1986. Willerson J, David Hillis L, Winniford M and Maximilian Buja L (1986) Speculation regarding mechanisms responsible for acute ischemic heart disease syndromes, Journal of the American College of Cardiology, 10.1016/S0735-1097(86)80121-8, 8:1, (245-250), Online publication date: 1-Jul-1986. Toto R, Anderson S, Brown–Cartwright D, Kokko J and Brater D (1986) Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency, Kidney International, 10.1038/ki.1986.253, 30:5, (760-768), Online publication date: 1-Nov-1986. Redfern J and Feldman M (1986) Lack of specific binding of prostaglandin E2, prostaglandin F2α, and 6-Keto Prostaglandin F1α to serum in patients with peptic ulcer disease and in healthy subjects, Gastroenterology, 10.1016/0016-5085(86)90440-3, 91:1, (71-74), Online publication date: 1-Jul-1986. Apprill P, Schmitz J, Campbell W, Tilton G, Ashton J, Raheja S, Buja L and Willerson J (1985) Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors., Circulation, 72:2, (397-405), Online publication date: 1-Aug-1985.Campbell W, Currie M and Needleman P (1985) Inhibition of aldosterone biosynthesis by atriopeptins in rat adrenal cells., Circulation Research, 57:1, (113-118), Online publication date: 1-Jul-1985.Schmitz J, Apprill P, Buja L, Willerson J and Campbell W (1985) Vascular prostaglandin and thromboxane production in a canine model of myocardial ischemia., Circulation Research, 57:2, (223-231), Online publication date: 1-Aug-1985. Hunyady L, Balla T, Enyedi P and Spät A (1985) The effect of angiotensin II on arachidonate metabolism in adrenal glomerulosa cells, Biochemical Pharmacology, 10.1016/0006-2952(85)90715-4, 34:19, (3439-3444), Online publication date: 1-Oct-1985. Baba K, Izumi Y, Atarashi K, Franco-Saenz R and Mulrow P (1985) Effect of indomethacin on the adrenal renin response to nephrectomy in the rat, Prostaglandins, 10.1016/0090-6980(85)90191-1, 30:2, (285-294), Online publication date: 1-Aug-1985. Hindawi R, Al-Dujaili E and Padfield P (1985) The role of prostaglandins in aldosterone and corticosterone secretion by isolated perfused rat zona glomerulosa cells, Prostaglandins, Leukotrienes and Medicine, 10.1016/0262-1746(85)90002-2, 20:2, (121-128), Online publication date: 1-Nov-1985. Munford R and Hall C (1985) Uptake and deacylation of bacterial lipopolysaccharides by macrophages from normal and endotoxin-hyporesponsive mice, Infection and Immunity, 10.1128/iai.48.2.464-473.1985, 48:2, (464-473), Online publication date: 1-May-1985. Naden R, Iliya C, Arant B, Gant N and Rosenfeld C (1985) Hemodynamic effects of indomethacin in chronically instrumented pregnant sheep, American Journal of Obstetrics and Gynecology, 10.1016/0002-9378(85)90275-3, 151:4, (484-494), Online publication date: 1-Feb-1985. Bush L, Campbell W, Kern K, Tilton G, Apprill P, Ashton J, Schmitz J, Buja L and Willerson J (1984) The effects of alpha 2-adrenergic and serotonergic receptor antagonists on cyclic blood flow alterations in stenosed canine coronary arteries., Circulation Research, 55:5, (642-652), Online publication date: 1-Nov-1984.Taylor T, Moore T, Hollenberg N and Williams G (1984) Converting-enzyme inhibition corrects the altered adrenal response to angiotensin II in essential hypertension., Hypertension, 6:1, (92-99), Online publication date: 1-Jan-1984. Willerson J, Campbell W, Winniford M, Schmitz J, Apprill P, Firth B, Ashton J, Smitherman T, Bush L and Buja L (1984) Conversion from chronic to acute coronary artery disease: Speculation regarding mechanisms, The American Journal of Cardiology, 10.1016/S0002-9149(84)80095-8, 54:10, (1349-1354), Online publication date: 1-Dec-1984. Engle W, Arant B, Wiriyathian S and Rosenfeld C (1983) Diuresis and respiratory distress syndrome:Physiologic mechanisms and therapeutic implications, The Journal of Pediatrics, 10.1016/S0022-3476(83)80024-9, 102:6, (912-917), Online publication date: 1-Jun-1983. Firth B, Winniford M, Campbell W and Hillis L (1983) Hemodynamic effects of intravenous prostacyclin in stable angina pectoris, The American Journal of Cardiology, 10.1016/0002-9149(83)90003-6, 52:5, (439-443), Online publication date: 1-Sep-1983. Campbell W, Holland O, Adams B and Gomez-Sanchez C (1982) Urinary excretion of prostaglandin E2, prostaglandin F2 alpha, and thromboxane B2 in normotensive and hypertensive subjects on varying sodium intakes., Hypertension, 4:5, (735-741), Online publication date: 1-Sep-1982. Alhenc-Gelas F, Tsai S, Callahan K, Campbell W and Johnson A (1982) Stimulation of prostaglandin formation by vasoactive mediators in cultured human endothelial cells, Prostaglandins, 10.1016/0090-6980(82)90040-5, 24:5, (723-742), Online publication date: 1-Nov-1982. Hirsh P, Firth B, Campbell W, Willerson J and Hillis L (1982) Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease, American Heart Journal, 10.1016/0002-8703(82)90198-3, 104:2, (234-237), Online publication date: 1-Aug-1982. Balla T, Enyedi P and Spät A (1982) Role of calcium ions and calmodulin in the aldosterone stimulating action of prostaglandin E2, Journal of Steroid Biochemistry, 10.1016/0022-4731(82)90066-8, 16:3, (493-494), Online publication date: 1-Mar-1982. Lijnen P, Staessen J, Fagard R and Amery A (1982) Increase in plasma aldosterone during prolonged captopril treatment, The American Journal of Cardiology, 10.1016/0002-9149(82)90390-3, 49:6, (1561-1563), Online publication date: 1-Apr-1982. Hirsh P, Hillis L, Campbell W, Firth B and Willerson J (1981) Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease, New England Journal of Medicine, 10.1056/NEJM198103193041201, 304:12, (685-691), Online publication date: 19-Mar-1981. July 1980Vol 2, Issue 4 Advertisement Article InformationMetrics Copyright © 1980 by American Heart Associationhttps://doi.org/10.1161/01.HYP.2.4.471PMID: 7399628 Originally publishedJuly 1, 1980 PDF download Advertisement

We studied the effects of furosemide on urinary excretion of PGE2 and sodium and the effects of inhibition of prostaglandin (PG) synthesis with indomethacin or furosemide-induced PGE2 excretion and natriuresis in normal man. Furosemide (20 mg i.v.) increased the urinary excretion of PGE2 from 71.2 ± 17.2 to 255.9 ± 41.0 ng/4 h. Sodium excretion increased in parallel. Indomethacin, in a dose sufficient to decrease basal urinary PGE2 excretion by >90%, significantly decreased both urinary PGE2 and sodium excretion under furosemide without affecting delivery of furosemide into the urine. The urinary excretion of furosemide was 9.4 ± 0.4 and 9.3 ± 1.4 mg/24 h with and without indomethacin, respectively. However, the furosemide-induced encrement in PGE2 excretion and sodium excretion over baseline was not changed. Furosemide-stimulated urinaary PGE2 excretion correlated significantly with sodium excretion rate with and without indomethacin. Indomethacin changed the relationship between absolute amounts of furosemide in urine and PGE2 excretion but did not affect the increment in excretion over baseline or the significant correlation of urinary PGE2 with sodium excretion.