Anisotropical engineering of surface-confined supramolecules provides a potential approach to precisely tweaking the properties and performance of low-dimensional molecular nanomaterials. Here, we report the construction of a surface-confined bicomponent supramolecular structure that features structural anisotropy by combined scanning tunneling microscopy and density functional theory studies. One-dimensional supramolecular ribbons formed by corannulene with either titanyl phthalocyanine or copper phthalocyanine exclusively extend along the equivalent <1<(1)over bar>0> directions on Ag(111). Such a supramolecular anisotropy is demonstrated as a result of the combined effects of molecule-substrate commensurability and intermolecular interaction relaxation, which leads to orientation-dependent energy cost for commensurate growth of the supramolecular ribbon on Ag(111). These findings provide insights into the mediation effect of the fine balance between the molecule-substrate and intermolecular interactions on the supramolecular structures, offering an efficient methodology for supramolecular anisotropical engineering.

Thermally deposited picene (C22H14) molecules on a monolayered CuO film were grown at a Cu(110) self-assemble into side-on molecular strips extending along the [1 (1) over bar0] direction, as revealed by scanning tunneling microscopy (STM). The picene molecules are closely stacked on and anchored to the Cu-O chains via their armchair edges. They form two stacking modes and stick to the substrate via their long (Pic-I) and short (Pic-II) armchair edges. Such configurations are reversibly switchable by either an applied STM bias voltage pulse or continuous tip navigation. Scanning tunneling spectroscopies acquired above the Pic-I and Pic-II strips reveal different electronic states, showing a clear relationship between their electronic structures and their stacking modes on the substrate.

The direction and spatial distribution of charge transfer between a single atom and its support are key factors for SAC performance.

Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals worldwide. While COVID-19 generally affects the lungs, it also damages other organs, including those of the cardiovascular system. Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disorder. Studies have shown that HCM patients with COVID-19 have a higher mortality rate; however, the reason for this phenomenon is not yet elucidated. Herein, we conducted transcriptomic analyses to identify shared biomarkers between HCM and COVID-19 to bridge this knowledge gap. Differentially expressed genes (DEGs) were obtained using the Gene Expression Omnibus ribonucleic acid (RNA) sequencing datasets, GSE147507 and GSE89714, to identify shared pathways and potential drug candidates. We discovered 30 DEGs that were common between these two datasets. Using a combination of statistical and biological tools, protein-protein interactions were constructed in response to these findings to support hub genes and modules. We discovered that HCM is linked to COVID-19 progression based on a functional analysis under ontology terms. Based on the DEGs identified from the datasets, a coregulatory network of transcription factors, genes, proteins, and microRNAs was also discovered. Lastly, our research suggests that the potential drugs we identified might be helpful for COVID-19 therapy.

The conformational isomers of Salen molecules and their self-assembled structures on coinage metal surfaces.

Controlled construction of molecule-based nano-structures with specific spin-state ordering is significant for design of spintronic devices and magnetic materials. Here, we report on the fabrication of metallo-supramolecular chains featuring varied spin-state phases on different lattice planes of the Au substrate. The one-dimensional molecular structures are formed by coordination between deprotonated tetrahydroxybenzene and Ni on Au(100) and Au(110). By employing scanning tunneling microscopy/spectroscopy and density functional theory calculations, we identify Ni atoms in the coordination chains on Au(100) and Au(110) at a low-spin (LS, S = 0) and high-spin (HS, S = 1) state, respectively, giving rise to the LS phase on Au(100) and the HS phase on Au(110). We demonstrate that the selective stabilization of the different spin-state orderings on the Au substrates stems from the distinct ground states of the spin-state phase at varied Ni-Ni separations in the chains on the different Au surfaces. Such a lattice-plane-dependent variation in Ni-Ni distance is revealed as a result of the chain-substrate commensurability. These findings provide insights into the key role of the substrate effect in tuning the magnetic properties of surface-confined supramolecular systems.

Potassium (K) cations are spontaneously formed upon thermal deposition of low-coverage K onto an ultrathin CuO monolayer grown on Cu(110) and they were explored by low-temperature scanning tunneling microscopy (STM) and X-ray photoemission spectroscopy. The formed K cations are highly immobile and thermally stable. The local work function around an individual K cation decreases by 1.5±0.3 eV, and a charging zone underneath it is established within about 1.0 nm. The cationic and neutral states of the K atom are switchable upon application of an STM bias voltage pulse, which is simultaneously accompanied by an adsorption site relocation.

We first consider a second order coupled differential system with nonlinearities involved two unknown functions and their derivatives, subject to a new kinds of multi-point and multi-strip boundary value conditions. Since the coupled system contains two dependent variables and their derivatives, the classical method of upper and lower solutions on longer applies. So we adjust and redefine the forms of upper and lower solutions, to establish the existence results. Secondly, we study a Caputo fractional order coupled differential system with discrete multi-point and integral multi-strip boundary value conditions which are very popular recently, and can accurately describe a lot of practical dynamical phenomena, such as control theory, biological system, electroanalytical chemistry and so on. In this part the existence and uniqueness results are achieved via the Leray-Schauder's alternative and the Banach's contraction principle. Finally, an example is presented to illustrate the main results.

Objective: To analyse the correlation of cytokines interleukin-10 (IL-10) and interleukin-17 (IL-17) with blood pressure and immune level in patients with essential hypertension. Methods: From September 2017 to February 2019, 81 patients with essential hypertension were randomly selected as the study group, and 81 healthy people who underwent physical examinations in our hospital at the same time were selected as the control group. The 24-hour mean diastolic blood pressure, 24-hour mean systolic blood pressure, levels of cytokines IL-10 and IL-17 and changes of immune function indexes (immunoglobulin G [IgG] CD4+, CD8+, CD4+/CD8+ car) were observed in all subjects. A Pearson correlation test was used to analyse the correlation between cytokines IL-10, IL-17 and blood pressure and immune levels in patients with essential hypertension. Result: Compared with the control group, the average diastolic blood pressure and systolic blood pressure in the study group increased significantly after 24 hours (P<05). The level of cytokine IL-10 in the study group was significantly lower than that in the control group, and the level of IL-17 was significantly higher than that in the control group (P<.05). Compared with the control group, the levels of IgG and CD8+ in the study group increased significantly, while the levels of CD(4)(+)and CD4+ ICDs - decreased significantly ( P<.05). The Pearson correlation test showed that the IL-10 level was negatively correlated with 24-hour mean systolic blood pressure, 24-hour mean diastolic blood pressure and IgG and CD8+ levels, and positively correlated with CD4+ and CD4+ /CD8+ levels (P<.05). The IL-17 level was positively correlated with 24-hour mean systolic blood pressure and 24-hour mean diastolic blood pressure in essential hypertension patients (P<.05). The levels of IgG and CDs - were positively correlated, but negatively correlated with the levels of Ca-4(+), CD4+ and CD8+ - (P<.05). Conclusion: The level of IL-10 in patients with essential hypertension is significantly lower than that in healthy subjects, and the level of IL-17 is significantly higher than that in healthy subjects. The above indexes are correlated with blood pressure and immune function.

AbstractPotassium (K) cations are spontaneously formed upon thermal deposition of low‐coverage K onto an ultrathin CuO monolayer grown on Cu(110) and they were explored by low‐temperature scanning tunneling microscopy (STM) and X‐ray photoemission spectroscopy. The formed K cations are highly immobile and thermally stable. The local work function around an individual K cation decreases by 1.5±0.3 eV, and a charging zone underneath it is established within about 1.0 nm. The cationic and neutral states of the K atom are switchable upon application of an STM bias voltage pulse, which is simultaneously accompanied by an adsorption site relocation.

In this paper, we consider the existence of solutions for the fractional differential equations with multi-point and multi-strip boundary conditions. The existence results are obtained by applying Leray–Schauder’s alternative, while the uniqueness of solution is established via Banach’s contraction principle. We also consider the existence of positive solutions for the fractional differential equations with degenerated multi-strip integral boundary conditions. We come to the results by applying the Krasnoselskii’s fixed point theorem. Some examples are also presented to illustrate the main results.

The adsorption, assembly, and growth mechanism of the optoelectronic titanyl phthalocyanine (TiOPc) molecules on Au(111) were carefully investigated by low-temperature and high-resolution scanning tunneling microscopy (STM). Three domains, i.e., Y, I, and II, were formed on Au(111) with its coverage increased up to six monolayers (MLs), as structurally scrutinized at the submolecular level. The TiOPc molecules were adsorbed with their Pc planes parallel to the substrate surface in domains Y and I, while the Pc planes tilted against the surface with two lobes pointed toward the vacuum in domain II. A growth mode transition from layer-by-layer to bilayer-by-bilayer was experimentally observed in domains Y and I when the TiOPc coverage exceeded 2 ML, while domain II remained unchanged. The stable double-layer island growth, i.e., O-up and O-down in odd- and even-numbered layers, respectively, was maintained as the coverage increased in domains Y and I. Detailed structural analyses based on the wsubmolecular resolution STM imaging indicated that domains Y, I, and II corresponded to polymorphic crystal phases Y-TiOPc, I-TiOPc, and deformed II-TiOPc grown on Au(111), which were frequently missed in previous studies due to the lack of subtle structural details by high-resolution images. Such a structural clarification of the grown TiOPc films should help in the understanding of the relationship between their optoelectronic device performance and polymorphism of the polycrystalline TiOPc thin films.

Ceria has been widely applied as a support in heterogeneous catalysis due to its unique capability to store and release oxygen. As a typical inverse model catalyst, a ceria/Pt(111) system has attracted much attention due to its strong metal-oxide interaction. The structural and electronic properties of the ceria/Pt(111) system can be effectively modified by the introduction of alien K and Rh atoms. Here, the K- and Rh-modified ceria/Pt(111) inverse model catalysts have been investigated with high resolution scanning tunneling microscopy and apparent local work function measurement. The experimental results indicate that the K atoms prefer to occupy the top sites of the stoichiometric ceria, while the Rh atoms are prone to stay at the electron-rich ceria island edges. The K and Rh atoms act as an electron donor and acceptor on ceria/Pt(111), respectively. Such a study on the modification of the ceria-based catalysts should help understand strong metal-oxide interaction in heterogeneous catalysis at the atomic level.

The contradiction between Distributed WebGIS massive data and the limited bandwidth of network resources is becoming more and more serious, and the inquiry of vector data and transmission of massive data between the client and the server end has become the critical key of the problem. Based on analysis of the two frameworks of WebGIS and the properties of intelligent Agent in the field of Distributed WebGIS, this article attempts to present a hybrid model WebGIS framework. The experiment for cable monitoring system conducted in State Grid in Beijing has proved that this framework is effective on improving the inquiry speed and maintaining a good network-load performance.