目的 分析腹腔镜联合胆道镜胆总管探查术治疗胆总管结石对患者生化指标的影响.方法 选取于该院行开腹手术治疗的39例胆总管结石患者作为对照组;另选于该院行腹腔镜联合胆道镜胆总管探查术治疗的39例胆总管结石患者作为观察组.比较两组围术期指标、生化指标、并发症和预后情况.结果 所有患者均已顺利完成手术,观察组术中无中转开腹者.观察组的手术用时比对照组长,而术中失血量比对照组低,且切口长度、禁食时间、首次下床时间、首次排气时间均比对照组短,差异均有统计学意义(P<0.05).观察组术后7 d的血清丙氨酸氨基转移酶(ALT)、血清碱性磷酸酶(ALP)、天门冬氨酸氨基转移酶(AST)水平、总胆红素(TBIL)、间接胆红素(IBIL)及总胆汁酸(TBA)水平均比对照组低(P<0.05).观察组ALT、ALP、AST、TBIL、IBIL及TBA恢复正常的时间均比对照组短(P<0.05).观察组并发症发生率是15.38％,低于对照组的38.46％(P<0.05).随访过程中,观察组的结石复发率为2.56％,低于对照组的17.95％(P<0.05).结论 腹腔镜联合胆道镜胆总管探查术治疗胆总管结石的疗效显著,有助于改善围术期指标,提高手术治疗的安全性,促进肝功能等相关生化指标及预后情况的改善.

Objective To compare the clinical choosing principles of sedated colonoscopy with con-ventional colonoscopy. Methods Outpatients who were willing to accept colonoscopy with or without seda-tion were prospectively recruited,which were assigned to sedated colonoscopy group(n=362)and conven-tional colonoscopy group(n=323). All patients and endoscopists were asked to answer a self-administered questionnaire. The colonoscopy completion,operation time,procedure-related discomfort,and questionnaire results of the two groups were compared and statistically analyzed. Results The completion rate was 98. 9%in the sedated colonoscopy group(358/362)and 89. 8% in the conventional colonoscopy group(290/323) ( P=0. 337 ). The operation time of sedated and conventional group were( 5. 60 ± 3. 25 ) minutes and (7. 71 ± 5. 70)minutes respectively(P<0. 001). And the average cost was CNY 886. 54 per patient in se-dated group and CNY 386. 00 per patient in the conventional group. Patient satisfaction score of conventional group and sedated group were 4(3-4)and 3(2-3)points(P<0. 001),while endoscopist satisfaction score was 4(3-4)and 4(4-4)(P<0. 001). A total of 354 patients(97. 79%)in the sedated group and 225 pa-tients(69. 66%)in the conventional group showed willingness to repeat the identical colonoscopy( P <0. 001). Patients who were male(P=0. 035),having no past abdominal operations(P<0. 001),or no ab-dominal pain during colonoscopy( P =0. 015 )in the conventional group preferred to repeat conventional colonoscopy. Conclusion Although the examination time of conventional colonoscopy is longer than sedated colonoscopy,it could reduce anesthesia risk and the cost. Conventional colonoscopy remains an irreplaceable examination of colorectal diseases in developing countries. Physicians should not only focus on patients'com-fort during endoscopy,but also help patients make a decision based on their actual situation and endoscopic indications to make the best of medical resources.

目的 探讨双气囊小肠镜对小肠出血手术定位的临床应用价值.方法 回顾性分析2003年6月至2005年12月间行双气囊小肠镜检查并行手术探查的56例小肠出血患者的临床资料.将术前小肠镜诊断结果与术中检查所见加以比较,并随访手术治疗的效果.结果 54例(96%)经术前双气囊小肠镜检查发现出血病灶,其中53例(95%)术前的病灶定位与术中发现的病变部位基本一致,4例定性诊断不一致,1例手术探查未发现病灶.间质瘤是本组患者中导致小肠出血的最常见病因.结论 双气囊小肠镜对小肠出血术前定位具有可靠的临床价值。