Polyphenols present in various plant and vegetable extracts possess enormous antioxidant, anti-inflammatory, anti-carcinogenic and anti-atherogenic qualities providing medical benefits. Antioxidants scavenge free radicals and other reactive oxygen species (ROS) by interrupting their mechanism of oxidation. Since free radicals cause neurological illnesses, cancer, heart disease, diabetes, atherosclerosis, and lipid and DNA damage, inhibiting their formation has recently been the subject of several medical investigations. Present studies described the determination of total phenolic content and DPPH activity of a large number of commonly used plant and vegetable extracts utilizing Folin-Ciocalte and Soler-Rivas procedures. This study aims to conduct a biochemical analysis of the therapeutic effects of okra, tamarind, and other phenolic compounds. The comparative data provided in this work for antioxidant and polyphenolic substances is expected to be highly valuable for readers who are interested in this subject.
Recently, the anti-glycation and anticancer properties of curcumin longa and okra seed extract were studied alone and also in combination with the well-established drug metformin.The combined effect of curcumin with metformin and metformin with okra seed extract was found to be highly efficacious in inhibiting Advanced Glycation End-products (AGEs).In order to understand the mechanistic implications of curcumin combined with metformin and its enhanced anti-glycation activity, a Curcumin-Metformin Adduct was chemically synthesized.This adduct was fully characterized by thin-layer chromatography, Nano Drop spectrophotometry and electrospray-ionization mass spectrometry.The adduct may be helpful not only in elucidating the mechanism of anti-glycation and anti-cancer activities but also in studying the role of curcumin in binding of Aβ-oligomers and disaggregating fibrillar formation in Alzheimer's disease.