Objective: This study aimed to assess the diagnostic value of combined detection of computed tomography (CT), serum homo-cysteine (Hcy), cystatin C (Cyst-C), and uric acid (UA) concentrations for hypertensive left ventricular hypertrophy.Methods: The present study matched 50 patients with primary hypertension without left ventricular hypertrophy (control group) with 50 patients with primary hypertension with left ventricular hypertrophy (HLVH group) from March 2019 to May 2020. The serum Hcy, Cyst-C, UA levels, IVST (interventricular septum thickness), LVDD (left ventricular end-diastolic diameter), LVPWT (left ventricular posterior wall thickness), LVEF (left ventricular ejection fraction), LVFS (left ventricular fraction shortening), and blood lipid levels were compared between the two groups. The specificity, sensitivity, and accuracy of CT combined with serum Hcy, Cyst-C, and UA levels were compared between the two groups, and the correlation of serum Hcy, Cyst-C, and UA levels with HLVH was analyzed.Results: Patients with left ventricular hypertrophy showed poorer outcomes of serum Hcy, Cyst-C, UA levels, IVST, LVDD, LVPWT, LVEF, LVFS, and blood lipid levels versus those without (p < 0.05). Combined detection was associated with higher specificity, sensitivity, and accuracy versus single detection (p < 0.05). Serum Hcy, Cyst-C, and UA levels were positively corre-lated with hypertensive left ventricular hypertrophy (p < 0.05).Conclusions: Hybrid detection of CT and serum Hcy, Cyst-C, and UA levels substantially improve the diagnostic accuracy for hypertensive left ventricular hypertrophy.

Background: This study was to investigate the prevalence of preoperative rim enhancement, and its association with clinicopathological features, relapse, and survival profiles in Chinese basal-like breast cancer (BC) patients. Materials and Methods: The preoperative breast magnetic resonance imaging images of 145 basal-like BC patients who underwent surgical excision were obtained to determine rim enhancement. Besides, based on disease status and survival status during follow-up, the 1-year relapse rate/mortality, 3-year relapse rate/mortality, 5-year relapse rate/mortality were calculated; disease-free survival (DFS) and overall survival (OS) were determined. Results: There were 51 (35.2%) patients with rim enhancement and 94 (64.8%) patients without rim enhancement. Furthermore, rim enhancement was associated with larger tumor size and advanced T stage, whereas it did not associate with age, pathological differentiation, N stage, or TNM stage. In addition, rim enhancement was associated with higher 1-, 3-, and 5-year relapse rate and shorter DFS; meanwhile, rim enhancement was associated with increased 1-, 3-, and 5-year mortality rate and decreased OS. By multivariate Cox's regression analyses, rim enhancement, pathological differentiation, and N stage independently predicted reduced DFS; T stage independently predicted declined OS. Conclusion: Preoperative rim enhancement on MRI might be a possible noninvasive indicator for guiding personalized treatment strategies and improving prognosis in Chinese basal-like BC patients.

OBJECTIVE To investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) combined with multi-slice helical CT (MSCT) for gastric carcinoma and its lymph node metastasis (LNM). METHODS 150 patients with gastric carcinoma diagnosed in our hospital from July 2017 to July 2020 were enrolled for this retrospective study. The patients were all confirmed with gastric carcinoma by biopsy pathology. CEUS and MSCT were performed within one week before surgery. Logistic regression analysis was conducted to analyze the risk factors for LNM of gastric carcinoma. The diagnostic efficiency of CEUS and MSCT in gastric carcinoma and the screening efficiency of LNM were compared, and the sensitivity and specificity were calculated with the postoperative pathologic finding as the gold standard. The scores of lymph node reinforcement were compared. RESULTS There were 115 cases diagnosed with LNM while 35 were diagnosed without it by CEUS. MSCT results confirmed that there were 112 cases with LNM while 38 without. CEUS combined with MSCT confirmed that there were 116 cases with LNM while 34 cases were without. The sensitivity, specificity, and diagnostic coincidence rate of CEUS for LNM of gastric carcinoma were 89.07%, 70.96% and 85.33%, respectively. Those of MSCT were 84.87%, 64.51% and 80.66%, respectively. Those of CEUS combined with MSCT were 94.11%, 87.10%, and 92.67%, respectively. The reinforcement of CEUS combined with MSCT was better than either alone. CONCLUSION CEUS combined with MSCT is more effective in the diagnosis of LNM in gastric carcinoma patients. Hence, the combination of the two is helpful to enhance the accuracy of LNM diagnosis before operation.

This article is based on the use of GE combined with longitudinal lag time to quantify cardiac MRI screening for amyloidosis autologous thousand-cell transplantation, combined with clinical routine risk stratification, method for risk assessment of patients with amyloidosis and monitor the patient’s evaluation of the efficacy after treatment. Cardiac involvement with systemic amyloidosis is of great significance for both treatment and prognosis assessment, and is essential for quantitative and qualitative diagnosis or objectively providing prognostic value. In summary, myocardial amyloidosis needs to be studied before heart failure. It is recommended that patients undergo routine cardiac MRI examination to comprehensively evaluate cardiac morphology, function, risk stratification, prognosis, and treatment guidance. Diagnosis based on a single modality has been replaced by a comprehensive multi-modality method, and there is sufficient evidence to show the potential value of cardiac. However, with the continuous improvement of quality and value in the medical field, the field of cardiac will inevitably develop. The predicted and baseline indexes of myocardial strain predicted cardiac remission were 0.96 and 0.79, respectively. When the predictive value of clinical routine indicators and cardiac indicators is analyzed using blood response as the evaluation standard, the reduction in end-diastolic volume/body surface area (P = 0.031) can predict complete haematological remission. Folded cross-validation test shows that the end-diastolic volume/body surface area reduction and the baseline index IgG combined with myocardial strain predict AUC of complete blood remission of 0.78 and 0.76, respectively. This study will also continue to follow up and increase the sample size to verify the current conclusions.

This study aims to explore the possibility to apply intravoxel incoherent motion-magnetic resonance imaging (IVIM-MRI) in cardiac imaging. Multi-b-value diffusion-weighted imaging (DWI) sequence scanning was performed on 12 healthy volunteers. A double exponential model was adopted, and the b-value sequence was 0, 20, 60, 80, 120, 200, and 600second/mm(2). The D-value, D*-value, and fvalue of the anterior posterior and lateral walls of the ventricular septum were respectively measured on the short axis section of the heart, the parameters of the myocardium in different blood supply areas in each segment were recorded, and the measured data of these different segments were compared using analysis of variance. Among these 12 healthy volunteers, the D-value, D*-value, and f-value of these 72 segments were not exactly equal, the D-values of the myocardium in the 5th and 11th segment were lower than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P<. 001). Furthermore, the difference in D-value between the 5th and 11th segments was not statistically significant (P= 1.000). The D*-value and f-value of the myocardium in the 5th and 11th segment were higher than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P<. 001). Furthermore, the differences in D*-value and f-value between the 5th and 11th segments was not statistically significant (P=. 214,.787). The intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) technique can quantitatively reflect the diffusion and blood perfusion status of the myocardium.

Purpose: This study intended to determine the expression of AT rich interactive domain 1A (SWI-like) (ARID1A) in serum of glioma patients and explore the relevance between ARID1A expression and the prognosis of glioma patients. Methods: The expression of ARID1A in serum of glioma patients and healthy controls were measured by high performance liquid chromatography (HPLC). Chi-square test was applied to evaluate the statistical difference between ARID1A expression and the clinicopathologic characteristics. Kaplan-Meier analysis combing with log-rank test was used to compare the overall survival of glioma patients with different ARID1A expression. Cox regression analysis was performed to evaluate the relationship between ARID1A expression and the prognosis of glioma patients. Results: The ARID1A expression was significantly lower in serum of glioma patients than in the healthy controls (P < 0.001). Moreover, the ARID1A expression was closely related to pathological grading, age and KPS score (P < 0.05), while no relationship was found between ARID1A expression and gender, preoperative epilepsy, or tumor range (P > 0.05). Besides, the overall survival time of patients with high ARID1A expression was significantly longer than those with low ARID1A expression according to Kaplan-Meier analysis (P = 0.005). Cox regression analysis illustrated that ARID1A expression was a potential factor for prognosis of glioma patients and it might be an independent biomarker (P = 0.002, HR = 4.992, 95% CI = 1.831-13.611). Conclusion: In a word, our study indicated that down-regulation of ARID1A was a promising biomarker for the prognosis of glioma patients.

Objective: In this study, we examined the association between two adiponectin (ADPN) gene polymorphisms, +45 T/G and +276G/F, and susceptibility to diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients.Methods: A total of 180 T2DM patients were enrolled in this study and assigned to two groups: DPN group (n = 90) and non-DPN (NDPN) group (n = 90). In addition, 90 healthy subjects were chosen as healthy normal control (NC). The plasma level of ADPN was quantified by ELISA method and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotype analysis of the two ADPN polymorphisms, +45 T/G (rs2241766) and +276G/T (rs1501299), in all the study subjects. Statistical analysis of data was performed with SPSS version 20.0 software.Results: Serum levels of ADPN were markedly reduced in the DPN group compared to NDPN and NC groups (all P < 0.05). The frequencies of TT, TG and GG genotypes and the T and G alleles of T45G and G276T polymorphisms in DPN group were significantly different than the NDPN group (all P < 0.05). Notably, T45G and G276T polymorphisms were associated with significantly reduced plasma levels of ADPN in DPN and NDPN groups, compared to the NC group (P < 0.001). Significant difference in ADPN plasma levels were also observed between TT, TG and GG genotypes of T45G and G276T polymorphisms. Our results indicate that the T allele in +45 T/G and +276G/Tpolymorphisms is correlated with an elevated risk of DPN in T2DM patients. Haplotype analysis showed that GG and GT haplotypes showed a negative relationship with DPN, while TG haplotype positively correlated with risk of DPN in T2DM patients (all P < 0.05).Conclusion: Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level. (C) 2015 Elsevier Inc. All rights reserved.

The aim of this meta-analysis is to demonstrate whether diffusion-weighted magnetic resonance imaging (DWI) could assist in the precise diagnosis of cervical cancer or not. Both English and Chinese electronic databases were searched for potential relevant studies followed by a comprehensive literature search without any language restriction. Two reviewers independently assessed the methodological quality of the included trials. Standardized mean difference (SMD) and its corresponding 95 % confidence interval (95 % CI) were calculated in this meta-analysis. We chose Version 12.0 STATA statistical software to analyze our statistical data. Thirteen eligible cohort studies were selected for statistical analysis, including 645 tumor tissues and 504 normal tissues. Combined SMD of apparent diffusion coefficient (ADC) suggested that the ADC value in cervical cancer tissues was significantly lower than that of normal tissue (SMD = 2.80, 95 % CI = 2.64 ~ 2.96, P < 0.001). Subgroup analysis stratified by ethnicity indicated a higher ADC value in the normal tissues compared to the cancer tissues in both the Asian and Caucasian subgroups (Asians: SMD = 2.83, 95 % CI = 2.64 ~ 3.02, P < 0.001; Caucasians: SMD = 2.73, 95 % CI = 2.45 ~ 3.01, P < 0.001, respectively). The results from the subgroup analysis by MRI machine type revealed a statistically significant difference in ADC value between normal cervical tissue and tumor tissues among all of the six MRI machine type subgroups (all P < 0.05). The main finding from our meta-analysis revealed that increased signal intensity on DWI and decreased signal on ADC seem to be useful in the diagnosis of cervical cancer. DWI could therefore be an important imaging tool in potentially identifying patients with cervical cancer.