OBJECTIVE:To examine weight change associated with the use of mirtazapine compared with other antidepressants in elderly, depressed nursing facility residents.DESIGN:Retrospective cohort study.SETTING:Long-term care nursing facilities in the Southern California region.PARTICIPANTS:One hundred eighty-nine elderly patients (>65 years of age) who had a new episode or diagnosis of depression and stayed in the same facility for at least eight months.METHODS:The impact of antidepressant use on weight change and percentage weight change at three months and six months were assessed using Ordinary Least Squares (OLS) regression analysis. Mirtazapine served as the comparator drug.RESULTS:We found no statistically significant differences in weight change at three months and at six months between mirtazapine and all other nontricyclic antidepressants except for fluoxetine, which was associated with a gain of 3.8 pounds relative to mirtazapine at three months (P = 0.05). However, a hypertension diagnosis was associated with significant weight gain at three months (2.2 lbs., P = 0.04 or +1.7%, P = 0.03) and at six months (3.9 lbs., P = 0.005 or +3%, P = 0.006). A diagnosis of diabetes was associated with weight loss at six months (-3.7 lbs., P = 0.03; -3.2%, P = 0.02). Baseline weight was associated with increased weight loss in women at six months (-0.09 lb (per lb. baseline), P = 0.03).CONCLUSIONS:With the exception of fluoxetine, our study showed that the impact on weight using mirtazapine was not statistically different from other nontricyclic antidepressant users after controlling for factors such as baseline weight, gender, dose, and comorbid diagnoses.

ADVERTISEMENT RETURN TO ISSUEPREVArticleReduction of solutes hydrolysis by anion exchangersEhud Finkelstein, Bradley R. Williams, and Ron YanCite this: Ind. Eng. Chem. Prod. Res. Dev. 1986, 25, 1, 126–128Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/i300021a028https://doi.org/10.1021/i300021a028research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts