All treatment-emergent adverse events

Taxonomic differences from baseline between treatment arms at after antibiotic preconditioning and at C1D1

CD8 intra-tumoral infiltration percentage by IHC

Peripheral Treg populations of interest by baseline Ruminococcaceae status prior to initiating anti-PD1 therapy

Assessment of gut microbiome networks by treatment arm and across timepoints

Progression-free survival in a retrospective melanoma immunotherapy cohort by baseline Ruminococcaceae status

Summary of clinical response by treatment arm and baseline Ruminococcaceae group

Disease control and objective response rates by Ruminococcaceae status

Overview of exploratory correlative specimen availability

Best objective response by baseline Ruminococcaceae abundance levels

Longitudinal serum proteomics analysis

Patient characteristics by baseline Ruminococcaceae status

Differences in baseline peripheral immune cell populations by response and baseline Ruminococcaceae levels

Correlation between qPCR derived and WGS derived Ruminococcaceae family abundance at baseline

X50 High-parameter flow cytometry phenotypes and statistics

Gating strategy for X50 cytometric T-cell phenotyping

Ruminococcaceae family abdunance over time by stratification and arm

Intended study schema and CONSORT diagram

Patients with continued response at time of study conclusion

Changes in alpha diversity over time