A new study in Cell uses epigenome engineering to confer transgenerational inheritance of DNA methylation states and metabolic traits in mice.

Supplementary Figure Legends 1-2 from The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

Supplementary Table 1 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase

Abstractp14/p19ARF (ARF) is a tumor suppressor gene that is frequently mutated in human cancer. ARF has multiple tumor suppressor functions, some of which are mediated by signaling to p53. Surprisingly, a significant fraction of human tumors retain persistently high levels of ARF, suggesting that ARF may possess a prosurvival function. We show that ARF protein is markedly up-regulated in cells exposed to nutrient starvation. Cells with silenced ARF show reduced autophagy and reduced viability when placed under conditions of starvation. We show for the first time that ARF silencing can limit the progression of some tumors, such as lymphoma, but not others, such as E1A/Ras-induced tumors. Specifically, myc-driven lymphomas with mutant p53 tend to overexpress ARF; we show that silencing ARF in these tumors greatly impedes their progression. These data are the first to show that ARF can act in a p53-independent manner to promote the progression of some tumors. [Cancer Res 2008;68(23):9608–13]

Supplementary Figures 1-7 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase

Supplementary Figure 2 from The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.

Supplementary Figure 1 from The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

Two new studies in Science characterize a CRISPR-associated nuclease–protease system that can be leveraged as a programmable protease-based RNA sensor.

new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.

A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.

New work studying the plant Arabidopsis thaliana shows that patterns of observed sequence variants are primarily influenced by biases in initial mutation occurrences rather than by the subsequent selective pressures.

A new study in Science uses massively parallel reporter assays to show that human genetic associations are often driven by multiple genetic variants acting together within an associated locus.

Two new studies of mutations linked to distinct neurological conditions - autism spectrum disorders (ASD) and tuberous sclerosis complex (TSC) - use human brain organoids to identify mutation-driven alterations to cell lineage trajectories during early brain development.

Two new papers report programmable systems that leverage ADAR adenosine deaminases for recording transcript abundance.

Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.

new study in Nature uses mouse models of acute myeloid leukaemia to demonstrate that non-genetic transcriptional signatures are mitotically heritable determinants of clonal fitness that influence cancer progression.

study in the American Journal of Human Genetics shows that using the GRCh37 versus GRCh38 version of the human reference genome makes a meaningful difference to the calling of human genetic variants, with implications for research-based and clinical-based human sequencing studies.

Four new studies in Nature report multi-tissue analyses of somatic mutations from human donors, with insights into cell lineage commitment during embryonic development, as well as tissue-specific aspects of mutagenesis.

In this paper, the authors present sequence data from ancient mammoth specimens, including samples more than 1 million years old. The sequences provide insights into mammoth evolution and reveal that distinct mammoth lineages were present in eastern Siberia during the Early Pleistocene.