You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (PD08)1 Sep 2021PD08-03 EAU BCR RISK CLASSIFICATION AS DECISION TOOL FOR SALVAGE RADIOTHERAPY? A MULTICENTER STUDY Felix Preisser, Raisa Abrams-Pompe, Piter Jan Stelwagen, Dirk Boehmer, Fabio Zattoni, Alessandro Magli, Juan Gomez Rivas, Roser Vives Dilme, Matteo Sepulcri, Aritz Eguibar, Isabel Heidegger, Christoph Arnold, Christian Fankhauser, Felix Chun, Henk van der Poel, Gorgio Gandaglia, Thomas Wiegel, Roderick C N van den Bergh, and Derya Tilki Felix PreisserFelix Preisser More articles by this author , Raisa Abrams-PompeRaisa Abrams-Pompe More articles by this author , Piter Jan StelwagenPiter Jan Stelwagen More articles by this author , Dirk BoehmerDirk Boehmer More articles by this author , Fabio ZattoniFabio Zattoni More articles by this author , Alessandro MagliAlessandro Magli More articles by this author , Juan Gomez RivasJuan Gomez Rivas More articles by this author , Roser Vives DilmeRoser Vives Dilme More articles by this author , Matteo SepulcriMatteo Sepulcri More articles by this author , Aritz EguibarAritz Eguibar More articles by this author , Isabel HeideggerIsabel Heidegger More articles by this author , Christoph ArnoldChristoph Arnold More articles by this author , Christian FankhauserChristian Fankhauser More articles by this author , Felix ChunFelix Chun More articles by this author , Henk van der PoelHenk van der Poel More articles by this author , Gorgio GandagliaGorgio Gandaglia More articles by this author , Thomas WiegelThomas Wiegel More articles by this author , Roderick C N van den BerghRoderick C N van den Bergh More articles by this author , and Derya TilkiDerya Tilki More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001976.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Recently, a new prognostic model for patients harboring biochemical recurrence (BCR) after radical prostatectomy (RP) has been proposed by the European Association of Urology (EAU): EAU low-risk BCR (Gleason score <8 and prostate specific antigen doubling time (PSADT) >12months) vs. EAU high-risk BCR (Gleason score ≥8 or PSADT <=12months). However, whether this risk stratification may help choosing patients for salvage radiotherapy (SRT) remains unclear. METHODS: Retrospective analyses of 2473 RP patients who developed BCR and were treated between 1989 and 2020 (1121 with SRT and 1352 without SRT) within nine European institutional high-volume centers. Patients with adjuvant radiotherapy (RT) or lymph node invasion were excluded. Early SRT was defined as SRT delivered at PSA values <0.5ng/ml, late SRT was defined as SRT delivered at PSA values >=0.5ng/ml. Kaplan-Meier curves as well as multivariable Cox-regression analyses, adjusted for pathologic stage, age at RP, year of surgery and persistence PSA after RP, tested the effect of early SRT vs. late SRT vs. no RT on metastatic progression, death and cancer-specific death within each risk group. RESULTS: Overall, 805 patients were classified as EAU low- and 1574 patients EAU high-risk BCR, respectively. Median follow-up was 84.4 months (interquartile range: 48.4-129 months). For low-risk BCR patients, 12-yr overall and cancer-specific survival rates were 92.0 vs. 92.6 vs. 89.0% (p=0.1) and 100.0 vs. 100.0 vs. 97.6% (p=0.1) for early SRT vs. late SRT vs. no RT patients. For high-risk BCR patients, 12-yr overall and cancer-specific survival rates were 84.7 vs. 81.8 vs. 76.0% (p <0.01) and 95.1 vs. 94.2 vs. 82.7% (p <0.001) for early SRT vs. late SRT vs. no RT patients. In multivariable analyses, early SRT compared to no SRT decreased the risk for metastatic disease (HR: 0.41, p <0.001), death (HR: 0.67, p=0.04) and cancer specific death (HR: 0.27, p <0.001) only within the EAU high-risk BCR group. In patients classified as EAU low-risk BCR SRT compared to surveillance only was not decreasing the risk to metastatic disease, death or cancer specific death. CONCLUSIONS: Our data suggests that early SRT compared to no SRT improves cancer specific outcomes in men classified as EAU high-risk BCR. In contrast, in men classified as EAU low-risk BCR we were not able to show that early or late SRT improve cancer specific outcomes. These results suggest to recommend early SRT in men with EAU high-risk BCR. Conversely, surveillance only might be a suitable option for men classified as EAU low-risk BCR. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e114-e114 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Felix Preisser More articles by this author Raisa Abrams-Pompe More articles by this author Piter Jan Stelwagen More articles by this author Dirk Boehmer More articles by this author Fabio Zattoni More articles by this author Alessandro Magli More articles by this author Juan Gomez Rivas More articles by this author Roser Vives Dilme More articles by this author Matteo Sepulcri More articles by this author Aritz Eguibar More articles by this author Isabel Heidegger More articles by this author Christoph Arnold More articles by this author Christian Fankhauser More articles by this author Felix Chun More articles by this author Henk van der Poel More articles by this author Gorgio Gandaglia More articles by this author Thomas Wiegel More articles by this author Roderick C N van den Bergh More articles by this author Derya Tilki More articles by this author Expand All Advertisement Loading ...

BACKGROUND:Cerebral palsy (CP) is the most common motor impairment in childhood and often accompanied by a broad spectrum of comorbidities. Data are sparse concerning visual impairment (VI) and functional classification among CP children.OBJECTIVE:The objective of this study was to analyze the prevalence of VI among children with CP and to investigate a possible association between VI and Gross Motor Function Classification System (GMFCS) and the Bimanual Fine Motor Function (BFMF).METHODS:In this hospital-based study, records of 200 children with CP aged 2 to 17 years were reviewed.RESULTS:Overall, VI was found in 59.5% of children with CP. Prevalence of VI was higher when compared with non-CP children. A correlation between GMFCS as well as BFMF and severity of VI was found. Children with severe CP were at greater risk for severe VI, especially cerebral VI compared with children with mild CP.CONCLUSION:VI is a significant problem in children with CP and is correlated with motor function. Children with CP should undergo detailed ophthalmologic and orthoptic assessment to enable early intervention.