Heat exchangers play a vital a role in engineering implementations across various domains of engineering. The advent of nanofluids have enabled and facilitated better modes of heat transfer in heat exchangers. An experimental run is conducted to note the heat transfer characteristics of a helical coil heat exchanger with Aluminium oxide-water, copper oxide-water based nanofluids at three different concentrations (0.1 %,0.2 %,0.3 %). It was observed that there was an increase in heat transfer during the usage of nanofluids when compared to the conventional water being used as a working fluid. The increased heat transfer resulted in an increased effectiveness of heat transfer of the heat exchanger when run with the Aluminium oxide nanofluid and copper oxide nanofluid than water. The heat transfer characteristics of copper oxide nanofluid were more effective and efficient when compared to Aluminium oxide nanofluid. The experimental results were simulated in ANSYS Fluent and the simulated results correlate with the experimental results with minimal deviation (<4%)