Liver cancer is a public health problem worldwide, hepatocellular carcinoma (HCC) constituting 90% of cases. Although research is in continuous development, the prognosis of this type of cancer remains unfavorable, as selective treatments with low toxicity are necessary. Silibinin is a flavonoid recognized for its hepatoprotective effect, antioxidant and anti-inflammatory properties, and also for its proven effectiveness in cancer treatment when administered indiviadually or in association with conventional therapies.

Background: Polymeric micelles-based hydrogel formulation was developed using a mixture of two poloxamers, as solubilizers for – Origanum vulgare L. essential oil (OEO), but also as gelling agents. This topical product can represent an alternative to the current invasive approach for the management of skin tags, which include keratinocytes among the main constituents.

STEFANA AVRAM1*, CORINA DANCIU1, IOANA ZINUCA PAVEL1, RALUCA AMALIA CEAUSU2, SORIN AVRAM3, CRISTINA DEHELEAN4, MARIUS RAICA3 1 University of Medicine and Pharmacy Victor Babes, Faculty of Pharmacy, Department of Pharmacognosy, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2 University of Medicine and Pharmacy Victor Babes, Faculty of Medicine, Department of Histology, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 3 Institute of Chemistry of Romanian Academy Timisoara, Department of Computational Chemistry, 24 Mihai Viteazul Av., Timisoara, 300223, Romania 4 University of Medicine and Pharmacy Victor Babes, Department of Toxicology, Faculty of Pharmacy, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania

Nutraceuticals have lately been in the spotlight of research due to their significant contribution to the natural prevention of various health issues [1]. Lupinus albus L., commonly known as the white lupin, and Lupinus angustifolius L., commonly known as the narrow-leafed lupin or blue lupin, both included in the Fabaceae family, are two plant species known as nutraceuticals for their seeds. The Lupinus genus comprises over 200 species that contain approximately 36 – 52% proteins, 30 – 40%, fibers and 5 – 20% oil depending on the environmental or genetic conditions [2, 3]. Ethanolic extracts from the ungerminated and germinated seeds of Lupinus albus L. and Lupinus angustifolius L. were analyzed in terms of the content in total phenols, isoflavones and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial (against 5 bacterial strains: Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 700603), Staphylococcus epidermidis (ATCC 14990)), antiproliferative (four cancer cell lines: MCF7, MDA-MB-231 (breast cancers), A2780 (ovarian cancer) and SiHa (cervical cancer)) and antiinflammatory properties (ear model of inflammation), using in vitro and in vivo tests. Results have shown that germination is a method of choice in increasing the amount of total polyphenols, isoflavones and cinnamic acid derivatives in both Lupinus albus L. and Lupinus angustifolius L. seeds. However, biological evaluation of the antimicrobial, antiproliferative, anti-inflammatory activity of all vegetal extracts revealed an overall weak potential for both ungerminated and germinated seeds.