Study Objective: To establish the utility of selective tubal infusion of a saline-air mixture for sonographic identification of tubal patency (selective sonohysterosalpingography (SSHS)), including uterine cavity demonstration using the FemVue Catheter. Design: Multicenter prospective observation of twenty-three female volunteers (45 tubes) undergoing SSHS by FemVue in a single procedure. Setting: Seven sites in outpatient offices of various practice types (university and private obstetrics and gynecology practices, and infertility centers). Patients: Seventeen women (74%) with infertility and six women with unknown fertility. Intervention: Transcervical placement of the FemVue™ Catheter (Femasys Inc.) and infusion of sterile saline for sonohysterography followed by sequential advancement to each cornua under ultrasound guidance. The FemJect™ Saline-Air Device (Femasys Inc.) was then attached to the FemVue Catheter and a continuous sterile saline-air train was delivered to each tube during sonographic observation with video recording. Measurements and Main Results: The FemVue Catheter was used for a standard sonohysterogram, then advanced to each cornua in turn. The balloon was observed to be correctly positioned at the cornuas in all twenty-three patients allowing for the saline-air contrast to enter one tube at a time. Sonographic criteria for tubal patency were met by 89% (40/45) of the tubes, namely, sonographic observation of bubbles entering the fallopian tube combined with either sustained tube flow without production of a hydrosalpinx or exit of bubbles into the peritoneal cavity. Conclusion: The FemVue Catheter and FemJect Saline-Air Device allows sonographic determination of selective tubal patency in the outpatient office. This method allows complete sonographic assessment of the pelvic organs as well as specific demonstration of all the reproductive lumens in one office visit. This eliminates the need for an HSG referral, the use of synthetic chemical contrast agents, and exposure to radiation.