Our on-going goal is to improve and update the comparative genome organization between cattle and man but also among the most detailed mammalian species genomes i.e. cattle, mouse, rat and pig. In this work, we localized 195 genes in cattle and checked all human/bovine non-concordant localizations found in the literature. Next, we compiled all the genes mapped in cattle, goat, sheep and pig (2,166) for which the human ortholog with its chromosomal position is known, added corresponding data in mouse and rat, and ordered the genes relatively to the human genome sequence. We estimate that our compilation provides bovine mapping information for about 89% of the human autosomes. Thus, a near complete, overall and detailed picture of the number, distribution and extent of bovine conserved syntenies (regardless of gene order) on human R-banded autosomes is proposed as well as a comparison with mouse, rat and pig genomes.

taurus (cattle) 10, 16, 25, 32, 39, 42, 49, 53

Ferredoxin is a small, acidic, iron-sulfur protein that functions as an electron transport intermediate for mitochondrial cytochromes P450 involved in steroid, vitamin D, and bile acid metabolism. The FDX1 gene was located on human chromosome 11q22→q23 (OMIM). We have mapped the ferredoxin 1 gene in cattle in order to add gene loci to the cattle genome map and to expand knowledge of conserved synteny between human and cattle chromosomes.

Bone morphogenetic protein 1 (BMP1) has been proposed as a regulatory molecule involved in the binding or activation of other BMP molecules. It has been described as being identical to the enzyme C-proteinase that processes procollagens to fibrillar collagens. A fragment containing an exon of the bovine BMP1 gene was amplified from an adapter-ligated genomic DNA library. The isolated bovine BMP1 fragment was assigned by fluorescence in situ hybridization (FISH) to bovine (BTA) chromosome 8q21, a region containing an evolutionary breakpoint between homology to human (HSA) chromosomes 8 and 9. The assignment to BTA 8 was confirmed by using a hybrid somatic cell panel. The 3' intron region of the amplified genomic BMP1 fragment showed a SSCP polymorphism, and linkage analysis in the International Bovine Reference Panel (IBRP) of families confirmed the boundary position of this gene. The BMP1 gene presents total linkage (theta = 0.00, Z = 3.61) with the lipoprotein lipase gene on BTA 8 and HSA 8 and a larger recombination fraction (theta = 0.11, Z = 5.03) with the marker GGTB2 on BTA 8 and HSA 9. Physical and genetic mapping of the bovine BMP1 gene contribute to narrow the boundary between the HSA 8 and HSA 9 homology segments on BTA 8 and to the comparative mapping between BTA 8, murine chromosome MMU 14, and HSA 8.

A cattle genetic linkage map was constructed which covers more than 95 percent of the bovine genome at medium density. Seven hundred and forty six DNA polymorphisms were genotyped in cattle families which comprise 347 individuals in full sibling pedigrees. Seven hundred and three of the loci are linked to at least one other locus. All linkage groups are assigned to chromosomes, and all are orientated with regards to the centromere. There is little overall difference in the lengths of the bull and cow linkage maps although there are individual differences between maps of chromosomes. One hundred and sixty polymorphisms are in or near genes, and the resultant genome-wide comparative analyses indicate that while there is greater conservation of synteny between cattle and humans compared with mice, the conservation of gene order between cattle and humans is much less than would be expected from the conservation of synteny. This map provides a basis for high-resolution mapping of the bovine genome with physical resources such as Yeast and Bacterial Artificial Chromosomes as well as providing the underpinning for the interpolation of information from the Human Genome Project.

Research Articles| May 20 2008 Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization Subject Area: Genetics C. Elduque; C. Elduque aLaboratorio de Genética Bioquímica, Facultad de Veterinaria, Zaragoza (Spain); bLaboratoire Génétique biochimique et de Cytogénétique, INRA, Jouy en Josas (France) Search for other works by this author on: This Site PubMed Google Scholar P. Laurent; P. Laurent bLaboratoire Génétique biochimique et de Cytogénétique, INRA, Jouy en Josas (France) Search for other works by this author on: This Site PubMed Google Scholar H. Hayes; H. Hayes bLaboratoire Génétique biochimique et de Cytogénétique, INRA, Jouy en Josas (France) Search for other works by this author on: This Site PubMed Google Scholar C. Rodellar; C. Rodellar aLaboratorio de Genética Bioquímica, Facultad de Veterinaria, Zaragoza (Spain); Search for other works by this author on: This Site PubMed Google Scholar H. Levéziel; H. Levéziel bLaboratoire Génétique biochimique et de Cytogénétique, INRA, Jouy en Josas (France) Search for other works by this author on: This Site PubMed Google Scholar P. Zaragoza P. Zaragoza aLaboratorio de Genética Bioquímica, Facultad de Veterinaria, Zaragoza (Spain); Search for other works by this author on: This Site PubMed Google Scholar Cytogenetics and Cell Genetics (1997) 77 (3-4): 306–307. https://doi.org/10.1159/000134604 Article history Accepted: November 04 1996 Published Online: May 20 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation C. Elduque, P. Laurent, H. Hayes, C. Rodellar, H. Levéziel, P. Zaragoza; Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization. Cytogenetics and Cell Genetics 31 December 1997; 77 (3-4): 306–307. https://doi.org/10.1159/000134604 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsCytogenetic and Genome Research Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1997Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.

Journal Article Rapid communication: melanocyte stimulating hormone receptor (MC1R) maps to bovine chromosome 18 Get access L. A. Werth, L. A. Werth ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar G. A. Hawkins, G. A. Hawkins ABS Global, Inc., DeForest, WI 53532, USA To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Eggen, A. Eggen ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Petit, E. Petit ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Elduque, C. Elduque ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Kreigesmann, B. Kreigesmann ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar M. D. Bishop M. D. Bishop ABS Global, Inc., DeForest, WI 53532, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Animal Science, Volume 74, Issue 1, January 1996, Page 262, https://doi.org/10.2527/1996.741262x Published: 01 January 1996 Article history Received: 25 September 1995 Accepted: 24 November 1995 Published: 01 January 1996