The fertilization Ca2+ wave in Xenopus laevis is a single, large wave of elevated free cytosolic Ca2+ concentration that emanates from the point of sperm–egg fusion and traverses the entire diameter of the egg. This phenomenon appears to involve an increase in inositol-1,4,5-trisphosphate (IP3) resulting from interaction of the sperm and egg, which then results in the activation of the endoplasmic reticulum Ca2+ release machinery. We have proposed models based on a static elevated distribution of IP3, and dynamic [IP3], however, these models have suggested that the fertilization wave passes through the center of the egg. Complementing these earlier models, we propose a more detailed model of the fertilization Ca2+ wave in Xenopus eggs to explore the hypothesis that IP3 is produced only at or near the plasma membrane. In this case, we find that the wave propagates primarily through the cortex of the egg, and that Ca2+-induced production of IP3 at the plasma membrane allows IP3 to propagate in advance of the wave. Our model includes Ca2+-dependent production of IP3 at the plasma membrane and IP3 degradation. Simulations in 1 dimension and axi-symmetric 3 dimensions illustrate the basic features of the wave.