Skin cancer is an ever-expanding global health issue. UV radiation is the main etiological agent of most types of skin cancer. Photoprotection is critical to in skin cancer prevention. Sunscreens and physical barriers are the two primary photoprotective measures. This review summarizes current options in photoprotection, including physical barrier such as shade and clothing as well as sunscreens. In addition we look at how these photoprotective measures have influenced skin cancer rates and what can be done to improve the efficacy of existing photoprotective agents and devices.