Aromatic analogues of sialic acid (2 and 3) have been synthesized as potential influenza neuraminidase inhibitors. Whereas compound 2 exhibited good neuraminidase inhibitory activity, compound 3, possessing the glycerol side chain at the C-5 position, was not a neuraminidase inhibitor.
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A novel synthesis of 1-hydroxy-2-phosphonocyclobutenedione (4) is described.
