Protein synthesis in the cell, involves particulate elements called ribosomes which translate the information coded as specific nucleotide sequences in messenger RNA molecules into amino-acid sequences of proteins [1]. Ribosomes are frequently found in the cell in the form of aggregates called polysomes. The ribosomes in a polysome are believed to be attached to a single messenger RNA molecule and simultaneously to translate the encoded information to give polypeptides with a specific amino-acid sequence [2]. The basic mechanisms of the control of protein synthesis at the level of translation are not well understood.

The binding curves of oestradiol and testosterone to plasma membranes from male or female rat livers show no specific sites of high affinity. Plasma membranes from male and female rat livers show no disulphide interchange activity. It is concluded that no steroid‐promoted association of ribosome with plasma membranes occurs. Microsomes prepared from a homogenate from which plasma membranes have already been isolated, show a slightly higher concentration of specific high‐affinity steroid‐binding sites than do standard preparations of microsomes. It is concluded that standard microsomal preparations are contaminated only to a slight extent by fragments derived from the plasma membrane.

Smooth reticular membranes from male rat liver contain high affinity binding sites for oestradiol. Similar membranes from females contain analogous sites for testosterone. Rough membranes from which polysomes have been removed by EDTA (degranulated membranes), contain no high affinity binding sites for either hormone. Ethyl acetate extracts of degranulated membranes contain materials which block the high affinity binding sites on smooth membranes of the same but not the opposite sex. These extracts promote the attachment of ribosomes to smooth membranes of the same but not the opposite sex. The ethyl acetate extracts from male and female degranulated membranes contain substances which behave like oestradiol and testosterone, respectively.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic consequences of intermolecular attraction. I. Aminolysis of p-nitrophenyl decanoate and acetate by n-decylamine and ethylamineJeremy R. Knowles and Carol A. BlythCite this: J. Am. Chem. Soc. 1971, 93, 12, 3017–3021Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/ja00741a033https://doi.org/10.1021/ja00741a033research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Chemischer Informationsdienst. Organische ChemieVolume 2, Issue 36 Isocyclic Compounds ChemInform Abstract: KINETISCHE BEDEUTUNG DER INTERMOLEKULAREN ANZIEHUNG 1. MITT. AMINOLYSE VON DECANSAEURE- UND ESSIGSAEURE-P-NITROPHENYLESTER 2. MITT. DURCH N-N-ALKYLIMIDAZOLE KATALYSIERTE HYDROLYSE VON FETTSAEURE-P-NITROPHENYLESTERN CAROL A. BLYTH, CAROL A. BLYTHSearch for more papers by this authorJEREMY R. KNOWLES, JEREMY R. KNOWLESSearch for more papers by this author CAROL A. BLYTH, CAROL A. BLYTHSearch for more papers by this authorJEREMY R. KNOWLES, JEREMY R. KNOWLESSearch for more papers by this author First published: September 7, 1971 https://doi.org/10.1002/chin.197136191AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume2, Issue36September 7, 1971 RelatedInformation

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic consequences of intermolecular attraction. II. Hydrolysis of a series of fatty acid p-nitrophenyl esters catalyzed by a series of N-n-alkylimidazoles. A very simple esterase modelJeremy R. Knowles and Carol A. BlythCite this: J. Am. Chem. Soc. 1971, 93, 12, 3021–3027Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://doi.org/10.1021/ja00741a034RIGHTS & PERMISSIONSArticle Views103Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (853 KB) Get e-Alerts Get e-Alerts