Signaling through [Ca(2+)](i) is central to regulation of sperm activity and is likely to be the mechanism that transduces signals from the female reproductive tract to regulate sperm motility. In a recent paper1 we showed that exposure of sperm to nitric oxide mobilizes stored Ca(2+) in human sperm, an effect that occurs through nitrosylation of protein thiols. Not only did we find that NO* production by cells of the human female tract would be sufficient to elicit this effect, but progesterone, which is also present in the female tract and is synthesized by the oocyte vestments, acted synergistically with NO* to mobilize Ca(2+) and enhance flagellar beating. Here we argue that a Ca(2+) store at the junction of the sperm head and flagellum is subject to regulation by both progesterone and NO* and that ryanodine receptors at the store may be the point at which coincidence detection and synergistic interaction occurs.

Signaling through [Ca(2+)](i) is central to regulation of sperm activity and is likely to be the mechanism that transduces signals from the female reproductive tract to regulate sperm motility. In a recent paper1 we showed that exposure of sperm to nitric oxide mobilizes stored Ca(2+) in human sperm, an effect that occurs through nitrosylation of protein thiols. Not only did we find that NO* production by cells of the human female tract would be sufficient to elicit this effect, but progesterone, which is also present in the female tract and is synthesized by the oocyte vestments, acted synergistically with NO* to mobilize Ca(2+) and enhance flagellar beating. Here we argue that a Ca(2+) store at the junction of the sperm head and flagellum is subject to regulation by both progesterone and NO* and that ryanodine receptors at the store may be the point at which coincidence detection and synergistic interaction occurs.

Washington's so-called Maritime Strategy, which sought to apply US naval might against Soviet vulnerabilities on its maritime flanks, came to full fruition during the 1980s. The strategy, which witnessed a major buildup of US naval forces and aggressive exercising in seas proximate to the USSR, also explicitly targeted Moscow”s strategic missile submarines with the aim of pressuring the Kremlin during crises or the early phases of global war. Relying on a variety of interviews and newly declassified documents, the authors assert that the Maritime Strategy represents one of the rare instances in history when intelligence helped lead a nation to completely revise its concept of military operations.

The standard MS renormalization prescription is inadequate for dealing with multiscale problems. To illustrate this, we consider the computation of the effective potential in the Higgs-Yukawa model. It is argued that the most natural way to deal with this problem is to introduce a 2-scale renormalization group. We review various ways of implementing this idea and consider to what extent they fit in with the notion of heavy particle decoupling.