INTRODUCTION Clinical review, therapeutic drug monitoring (TDM) and adverse drug reaction (ADR) management contribute to the quality use of medicines by ensuring safe and appropriate dosage and administration of medicines, improving response to therapy and minimising medicinesrelated problems. Clinical review, TDM and ADR management commence when a patient presents or is admitted to a health service organisation and continue as routine activities throughout the episode of care in conjunction with assessment of current medication management and other clinical pharmacy activities.