In a survey of 49 papilloma patients accurate maternal condyloma history was obtained in 31 instances and of these, 21 were positive for the presence of condyloma during pregnancy or parturition. Molecular virological studies indicate that positive hybridization could be demonstrated to human papilloma virus 2 in both laryngeal papilloma and condyloma by the Southern blot technique. Immunoperoxidase staining illustrated the presence of virus-related particles only near the surface of the mucous membrane papilloma, which is in contrast to the definite staining of the stratum granulosum and stratum corneum of verrucae. Collectively this provides convincing evidence for an etiological relationship between condyloma acuminata and some laryngeal papillomata. The highly contagious nature of human papilloma virus infection is discussed and the possibility of cesarian section in the presence of active condyloma must be considered.

Annals of the New York Academy of SciencesVolume 354, Issue 1 p. 60-79 GENETIC VARIATION AMONG PAPILLOMAVIRUSES* Anthony J. Faras, Anthony J. Faras Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorRichard A. Krzyzek, Richard A. Krzyzek Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Supported by the National Institutes of Health (Young Investigators Award CA 23833).Search for more papers by this authorRonald S. Ostrow, Ronald S. Ostrow Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorSusan L. Watts, Susan L. Watts Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Supported by the National Institutes of Health (Training Grant 09138).Search for more papers by this authorDonna M. Smith, Donna M. Smith Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorDwight L. Anderson, Dwight L. Anderson Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorCedric A. Quick, Cedric A. Quick Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorFranklin Pass, Franklin Pass Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Departments of Microbiology and Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this author Anthony J. Faras, Anthony J. Faras Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorRichard A. Krzyzek, Richard A. Krzyzek Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Supported by the National Institutes of Health (Young Investigators Award CA 23833).Search for more papers by this authorRonald S. Ostrow, Ronald S. Ostrow Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorSusan L. Watts, Susan L. Watts Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Supported by the National Institutes of Health (Training Grant 09138).Search for more papers by this authorDonna M. Smith, Donna M. Smith Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorDwight L. Anderson, Dwight L. Anderson Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorCedric A. Quick, Cedric A. Quick Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this authorFranklin Pass, Franklin Pass Departments of Microbiology and §Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455 Departments of Microbiology and Dermatology University of Minnesota Medical School Minneapolis, Minnesota 55455Search for more papers by this author First published: November 1980 https://doi.org/10.1111/j.1749-6632.1980.tb27958.xCitations: 11 * Supported by the National Institutes of Health (Grants CA 25462 and CA 25124) and the Minnesota Leukemia Research Foundation. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume354, Issue1Genetic Variation of VirusesNovember 1980Pages 60-79 RelatedInformation

The clinical records and microscopic sections from 32 patients were reviewed in an attempt to correlate histopathologic features with clinical behavior. Three general clinical groups were identified on the basis of recurrence rates and extent of papillomatosis. In those lesions with the highest frequency of recurrences, epithelial atypia tended to be most pronounced. Although some of the lesions were quite disturbing, there was no evidence of invasive carcinoma. It remains unknown to date whether these cytologic abnormalities represent a neoplastic alteration or possibly atypia on the basis of rapid, but benign, cellular turnover. Further studies at our center and other institutions are necessary to test the proposed classification which, if validated, would provide a means of predicting the course of the disease and efficacy of the chosen management in these difficult cases.