Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR Association between alopecia areata and atopic dermatitis: Current evidence Wenwen Chen, Wenwen Chen Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 ChinaSearch for more papers by this authorSu Li, Su Li Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 ChinaSearch for more papers by this authorXiaoce Cai, Xiaoce Cai Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorChunxiao Wang, Chunxiao Wang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorSihan Wang, Sihan Wang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorKeke Huang, Keke Huang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorYan Chen, Corresponding Author Yan Chen [email protected] Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 China Correspondence Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Email: [email protected] Yan Chen, Chinese Medicine Department, Songnan Town Community Health Service Center, Shanghai 200441, China. Email: [email protected]Search for more papers by this authorXin Li, Corresponding Author Xin Li [email protected] orcid.org/0000-0003-2525-9679 Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 China Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 China Correspondence Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Email: [email protected] Yan Chen, Chinese Medicine Department, Songnan Town Community Health Service Center, Shanghai 200441, China. Email: [email protected]Search for more papers by this author Wenwen Chen, Wenwen Chen Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 ChinaSearch for more papers by this authorSu Li, Su Li Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 ChinaSearch for more papers by this authorXiaoce Cai, Xiaoce Cai Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorChunxiao Wang, Chunxiao Wang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorSihan Wang, Sihan Wang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorKeke Huang, Keke Huang Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 ChinaSearch for more papers by this authorYan Chen, Corresponding Author Yan Chen [email protected] Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 China Correspondence Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Email: [email protected] Yan Chen, Chinese Medicine Department, Songnan Town Community Health Service Center, Shanghai 200441, China. Email: [email protected]Search for more papers by this authorXin Li, Corresponding Author Xin Li [email protected] orcid.org/0000-0003-2525-9679 Chinese Medicine Department, Songnan Town Community Health Service Center, Baoshan District, Shanghai, 200441 China Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 China Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203 China Correspondence Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Email: [email protected] Yan Chen, Chinese Medicine Department, Songnan Town Community Health Service Center, Shanghai 200441, China. Email: [email protected]Search for more papers by this author First published: 13 March 2023 https://doi.org/10.1111/jdv.19044 Wenwen Chen and Su Li contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1Kageyama R, Kageyama R, Morishita N, Nakazawa S, Fujiyama T, Honda T, et al. Immunological properties of atopic dermatitis-associated alopecia areata. Int J Mol Sci. 2021; 22(5): 2618. 2Mohan GC, Silverberg JI. Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis. JAMA Dermatol. 2015; 151: 522– 8. 3Wei YH, Tai YH, Dai YX, Chang YT, Chen TJ, Chen MH. Bidirectional association between alopecia areata and atopic dermatitis: a population-based cohort study in Taiwan. Clin Exp Allergy. 2020; 50(12): 1406– 14. 4Andersen YM, Egeberg A, Gislason GH, Skov L, Thyssen JP. Autoimmune diseases in adults with atopic dermatitis. J Am Acad Dermatol. 2017; 76(2): 274– 280 e271. 5Roh YS, Huang AH, Sutaria N, Choi U, Wongvibulsin S, Choi J, et al. Real-world comorbidities of atopic dermatitis in the US adult ambulatory population. J Am Acad Dermatol. 2021; 86(4): 835– 45. 6Huang AH, Roh YS, Sutaria N, Choi J, Williams KA, Canner JK, et al. Real-world comorbidities of atopic dermatitis in the pediatric ambulatory population in the United States. J Am Acad Dermatol. 2021; 85(4): 893– 900. 7Drucker AM, Thompson JM, Li WQ, Cho E, Li T, Guttman-Yassky E, et al. Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses' health study 2. Allergy. 2017; 72(5): 831– 4. 8Suárez-Fariñas M, Ungar B, Noda S, Shroff A, Mansouri Y, Fuentes-Duculan J, et al. Alopecia areata profiling shows TH1, TH2, and IL −23 cytokine activation without parallel TH17/TH22 skewing. J Allergy Clin Immunol. 2015; 136: 1277– 87. 9Sorrell J, Petukhova L, Reingold R, Christiano A, Garzon M. Shedding light on alopecia areata in pediatrics: a retrospective analysis of comorbidities in children in the National Alopecia Areata Registry. Pediatr Dermatol. 2017; 34(5): e271– 2. 10Vu M, Heyes C, Robertson SJ, Varigos GA, Ross G. Oral tofacitinib: a promising treatment in atopic dermatitis, alopecia areata and vitiligo. Clin Exp Dermatol. 2017; 42(8): 942– 4. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation

Background We discovered that vitiligo was associated with sexual dysfunction in clinical diagnosis and treatment; however, no further analysis had been performed due to a lack of data. Objective This study aimed to clarify the relationship between vitiligo and sexual dysfunction. Methods We searched six databases (PubMed, Embase, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, and Wanfang Data Knowledge Service Platform) for nearly 40 years. Results According to the search strategy, 91 relevant studies were retrieved, of which 4 were included in the analysis. The Arizona Sexual Experience Scale (ASEX) score (mean difference [MD] 4.96, 95% confidence interval [CI] 2.78-7.13, p < 0.00001) was higher in the vitiligo group than in the control group. The Arabic version of the Female Sexual Function Index (AVFSFI) score (mean difference [MD] - 3.40, 95% confidence interval [CI] - 5.49 to -1.31, p = 0.001) was lower in the vitiligo group than in the control group. Conclusions Patients with vitiligo were found to be at greater risk of sexual dysfunction. Moreover, the association between vitiligo and sexual dysfunction was stronger in women than in men. Key Messages Patients with vitiligo were found to be at greater risk of sexual dysfunction. The association between vitiligo and sexual dysfunction was stronger in women than in men.

Background To date, there have no study comparing the associations between TyG index and HOMA-IR on the risk of incident albuminuria. Accordingly, the objective of the present study is to use discordance analysis to evaluate the diverse associations between TyG index and HOMA-IR on the risk of incident albuminuria. Methods A community-based prospective cohort study was performed with 2446 Chinese adults. We categorized participants into 4 concordance or discordance groups. Discordance was defined as a TyG index equal to or greater than the upper quartile and HOMA-IR less than the upper quartile, or vice versa. Results During a median follow-up period of 3.9 years, 203 of 2446 participants developed incident albuminuria (8.3%). In the multivariable logistic analyses, the high TyG index tertile group was associated with a 1.71-fold (95% confidence interval (CI) 1.07–2.72) higher risk of incident albuminuria, comparing with the low tertile group. Participants in TyG (+) & HOMA-IR (−) group had a greater risk of incident albuminuria compared with those in TyG (−) & HOMA-IR (−) group after multivariate adjustment. Subgroup analyses showed that low HOMA-IR and discordantly high TyG index was closely related to a highest risk of incident albuminuria in cardiovascular metabolic disorder subjects. Conclusions Participants with a discordantly high TyG index had a significantly greater risk of incident albuminuria, especially in metabolic dysfunction subjects. The TyG index might be a better predictor of early stage of chronic kidney disease than HOMA-IR for subjects with metabolic abnormality.