A high performance Ge FinFET CMOS invertor with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mathrm{I}_{\text{ON}}=2\quad \text{mA}/\mu\mathrm{m}$</tex> at <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mathrm{V}_{\text{OV}}\ =1\mathrm{V},\quad \mathrm{S}.\mathrm{S}.=64\quad \text{mV}/\text{dec}, \mathrm{I}_{\text{ON}}/\mathrm{I}_{\text{OFF}}=2.5\times 10^{6}$</tex> , and voltage gain=90 V/V is achieved by a high pressure supercritical fluid hydroxide oxidation, due to the reduced unstable oxidation states and oxygen vacancy.

Wafer-scale Si photonics testing through grating couplers has a great progress nowadays. Together with an image processing technique, a fully automated wafer-scale testing platform has been demonstrated. However, most of the devices are eventually diced and packaged with fiber arrays through edge coupling. Therefore, high-speed, on-wafer testing of device through edge coupling is preferable. Nevertheless, on-wafer coupling light to the waveguide edges without chip dicing is critical. Several approaches to fabricate optical probes for on-wafer edge coupling have been proposed, such as obliquely cutting the PLC chip [1] or using a 3D printing technique to make a lens-shaped structure at the end of a fiber tip [2]. All these approaches are to direct the guided wave from the top surface to the free space horizontally and illuminate light to the waveguide facet. However, fabricating these optical probes requires precision machining and assembly.

A high performance Ge FinFET CMOS invertor with ION=2 m Lambda/mu m at V-ov =1V, S.S.=64 mV/dec, I-ON/I-OFF=2.5x10(6), and voltage gain=90 v/v is achieved by a high pressure supercritical fluid hydroxide oxidation, due to the reduced unstable oxidation states and oxygen vacancy.

A high performance Ge FinFET CMOS invertor with $\mathrm{I}_{\text{ON}}=2\quad \text{mA}/\mu\mathrm{m}$ at $\mathrm{V}_{\text{OV}}\ =1\mathrm{V},\quad \mathrm{S}.\mathrm{S}.=64\quad \text{mV}/\text{dec}, \mathrm{I}_{\text{ON}}/\mathrm{I}_{\text{OFF}}=2.5\times 10^{6}$ , and voltage gain=90 V/V is achieved by a high pressure supercritical fluid hydroxide oxidation, due to the reduced unstable oxidation states and oxygen vacancy.

Most cancer vaccines under development are associated with defined tumor antigens rather than with all antigens of whole tumor cells, limiting the anti-tumor immune responses that they elicit. This work proposes an immunomodulator (R848)-loaded nanoparticle system (R848@NPs) that can absorb near-infrared light (+ NIR) to cause low-temperature hyperthermia that interacts synergistically with its loaded R848 to relieve the tumor-mediated immunosuppressive microenvironment, generating robust anti-tumor memory immunity. In vitro results reveal that the R848@NPs could be effectively internalized by dendritic cells, causing their maturation and the subsequent regulation of their anti-tumor immune responses. Post-treatment observations in mice in which tumors were heat-treated at high temperatures reveal that tumor growth was significantly inhibited initially but not in the longer term, while low-temperature hyperthermia or immunotherapy alone simply delayed tumor growth. In contrast, a combined therapy that involved low-temperature hyperthermia and immunotherapy using R848@NPs/ + NIR induced a long-lasting immunologic memory and consequently inhibited tumor growth and prevented cancer recurrence and metastasis. These results suggest that the method that is proposed herein is promising for generating cancer vaccines in situ, by using the tumor itself as the antigen source and the introduced R848@NPs/ + NIR to generate a long-term anti-tumor immunity, for personalized immunotherapy.