"Reverse perspective" is a powerful visual illusion similar to the hollow mask illusion, but more interesting in producing the perception of an illusory motion in a stationary picture. It is caused by conflict between motion parallax and pictorial depth cues in 3D "relief" paintings built with depth inversion. Here we report the measurement of brain activation using fMRI in response to a reverse perspective (RP) object, as well as a normal perspective, 3D-relief object ("shadow-box", SB) and a 2D painting of the same architectural scene. The stimuli were presented to 10 subjects in static and rotating conditions, subtraction of which revealed strong activation of area MT in all three cases. Contrasts between the RP, SB and 2D conditions showed the strongest activation for RP and almost no difference between SB and 2D. The similarity of brain activation between SB and 2D stimuli was interpreted as indicating that observers perceive the illusion of realistic 3D depth in 2D pictures as entirely normal and not qualitatively different from the 3D structure of the shadow-box stimulus. Contrasts between the RP stimulus and either the SB or the 2D stimulus revealed activation of Brodmann Areas 7, 19 and MT (and cerebellar cortex), suggesting the usage of brain regions involved in mental rotation and depth perception in response to the reverse perspective illusion.

The effects of taurine on serum cholesterol levels and hepatic cholesterol 7alpha-hydroxylase activity (CYP7A1) were studied in rats fed cholestyramine or high amounts of sodium cholate in order to alter the intestinal pool of bile acids. Rats were fed a diet supplemented with 1% cholesterol and 0.25% sodium cholate (high cholesterol, control; C), and C supplemented with 4% cholestyramine (CH) or 0.75% sodium cholate (BA) for 14d. Taurine groups were fed the diet supplemented with 3% taurine (CT, CHT and BAT). Compared to rats fed C and BA diets, serum cholesterol levels were significantly reduced in rats fed CT and BAT diets, but a significant reduction of serum cholesterol by taurine feeding was not observed in the CHT group as compared to the CH group. An increase in hepatic CYP7A1 activity due to taurine intake was observed in the CT and BAT groups. However, the simultaneous administration of cholestyramine and taurine (CHT group) did not increase hepatic CYP7A1 activity compared the intake of cholestyramine only (CH group). A significant increase in fecal bile acid excretion due to taurine intake was found only in rats fed the CT diet. In conclusion, it is suggested that taurine facilitates hepatic CYP7A1 activity regardless of the enlarged intestinal pool of bile acids due to increased intake of exogenous bile acid, and then reduces the serum cholesterol concentration.

The purpose of this study is to investigate the effect of taurine on the plasma cholesterol concentration in genetic type 2 diabetic rats fed cholesterol-free or high-cholesterol diets. Diabetic rats (GK male rats) and normal rats (Wistar male rats) were fed either a cholesterol-free or cholesterol-enriched (1% cholesterol+0.25% sodium cholate) diet supplemented with or without 3% taurine for 21. or 14 d. Compared to the normal rats, diabetic rats showed a high glucose concentration in their blood and plasma, but it was not affected by taurine feeding. The plasma insulin concentration was higher in the diabetic rats than in the normal rats. At the start of the experiment, the plasma cholesterol concentration was significantly higher in the diabetic rats than in the normal rats. Taurine did not affect the plasma cholesterol level in rats fed the cholesterol-free diet. However, taurine feeding significantly increased the plasma HDL-cholesterol concentration in the diabetic rats fed the cholesterol-free diet. In both the diabetic and normal rats fed the cholesterol diet, the plasma cholesterol concentration was significantly lower in rats fed the diet supplemented with taurine than in the rats fed the control diet. It was concluded that taurine has a hypocholesterolemic effect in both diabetic and normal rats fed diets containing cholesterol. Moreover, these results suggest that taurine seems to affect the HDL-cholesterol metabolism in diabetic rats fed a cholesterol-free diet.