Green chemistry, also called sustainable chemistry, is an area of chemistry and chemical engineering focused on the designing of products and processes that minimize the use and generation of hazardous substances. Whereas environmental chemistry focuses on the effects of polluting chemicals on nature, green chemistry focuses on the environmental impact of chemistry, including technological approaches to preventing pollution and reducing consumption of nonrenewable resources. The overarching goals of green chemistry—namely, more resource-efficient and inherently safer design of molecules, materials, products, and processes—can be pursued in a wide range of contexts. In the present book, twelve typical literatures about green chemistry published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on green synthesis, sustainable development, renewable feedstock, biodegradation, multi-component green synthesis and green cycle, etc. We hope this book can demonstrate advances in green chemistry as well as give references to the researchers, students and other related people.

Prior to market entry, new chemical substances are assessed for their risk to human health and the environment. Conventional risk assessment (RA) is limited in scope, i.e. it usually does not cover the entire life cycle of a substance, nor does it take into account sustainability aspects such as the amount of raw materials and energy required to produce the substance. Life cycle assessment (LCA) can provide this pivotal information to support an informed decision on the sustainability of a new substance. Unfortunately, LCA has had little regulatory application up to now. We believe that increasing the focus on combined use of LCA and life cycle-based RA could lead to improved regulatory long-term decisions for marketed chemicals. Inclusion of human biomonitoring could increase the robustness of such decisions even further. In addition, the combined use of the three methods allows a robust search for sustainable alternatives of currently marketed chemicals that have an unfavourable risk profile.

Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of “Green Chemistry” and “Green Engineering”, “Green Toxicology” aims to shape future manufacturing processes and safe synthesis of chemicals in terms of environmental and human health impacts. Being an integral part of Green Chemistry, the principles of Green Toxicology amplify the role of health-related aspects for the benefit of consumers and the environment, in addition to being economical for manufacturing companies. Due to the costly development and preparation of new materials and chemicals for market entry, it is no longer practical to ignore the safety and environmental status of new products during product development stages. However, this is only possible if toxicologists and chemists work together early on in the development of materials and chemicals to utilize safe design strategies and innovative in vitro and in silico tools. This paper discusses some of the most relevant aspects, advances and limitations of the emergence of Green Toxicology from the perspective of different industry and research groups. The integration of new testing methods and strategies in product development, testing and regulation stages are presented with examples of the application of in silico, omics and in vitro methods. Other tools for Green Toxicology, including the reduction of animal testing, alternative test methods, and read-across approaches are also discussed.

The key findings of a workshop jointly organized by the Swiss Centre of Applied Ecotoxicity, the Swiss Centre for Applied Human Toxicology (SCAHT), and the Federal Office of Public Health (FOPH) are summarized and provide a critical analysis of the current regulatory framework for nanomaterials and a snapshot of some hot topics in nanoscience.

Regulators and industry need clear rules for identification and grouping of nanomaterials for a streamlined quantitative hazard evaluation. Therefore, we provide convincing reasons for (i) why to introduce pragmatic definition of identities for nanomaterials, (ii) how to combine them into entities, and ultimately (iii) how the entities might be evaluated with testing strategies based on clouds of similar nanomaterials.