Radiolabeled 2H-imidazol-2-one angiotensin II AT1 receptor antagonists [3H]-SC-54628 and [3H]-SC-54629 have been synthesized from CBZ-gylcine. These radioligands have nominally four tritium atoms incorporated into the butyl group at the 4-position of the 2H-imidazol-2-ones.
Syntheses of tritium labeled guanidineacetic acid sweetener and a tritiated photoaffinty labeling reagent via the catalytic hydrogenation of the dibromo intermediates are described. These labeled compounds were required for the investigation of sweet taste mechanism.
AbstractThe synthesis of [3H] Aminocyclopropane carboxylic acid (ACC, 1) at high specific activity and high purity is described. The compound has been developed as a specific ligand for the Glycine‐B binding site.
