Abstract: Endotheiial cell activation is a major obstacle to successful xenotransplantation. The activated phenotype is largely based on the transcriptional induction of a number of genes and their products. Due to the large number of new gene products in activated endotheiial cells, it is not feasible to target each of them individually for therapeutic intervention. A common factor important for the induction of many, if not all, genes induced upon endotheiial cell activation if NF‐KB. It is thus a reasonable target for inhibition if one is to attempt to inhibit endotheiial cell activation genetically. Donor animals for xenotransplantation are amenable to genetic manipulation and we believe that transgenic animals carrying several transgenes will be the standard of future experimental and clinical xenotransplantation.
Hans Winkler合作论文数4
Fritz H. Bach合作论文数Harvard Medical School4
Simon Robson合作论文数Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center;Department of Anesthesia, Beth Israel Deaconess Medical Center;Division of Medical Sciences, Harvard Griffin Graduate School of Arts and Sciences, Harvard University;Liver Center, University of Cape Town;Harvard Medical School, Harvard University;Inner Mongolian Medical College;Department of Medicine, New England Deaconess Hospital3
Wayne William Hancock合作论文数Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania;Division of Transplant Immunology, Children’s Hospital of Philadelphia3Christiane Ruedl合作论文数2Brian L. Matthews合作论文数2Yoshimi Takata合作论文数2Yoshiki Gonokami合作论文数2Mitsutaka Takami合作论文数2Koichi Miyagi合作论文数2Isabella Marinò合作论文数2Esperanza Feijoó合作论文数2peter hecht合作论文数2Anna Sz. Kenderessy合作论文数2Takuma Furitsu合作论文数2Wataru Tsukada合作论文数2Etsuko Takamura合作论文数2Masahiro Morimoto合作论文数2Shin-ichi Konno合作论文数2Paweł Górski合作论文数2
Lajos Kemeny合作论文数2wolfgang schmidt合作论文数2Erik Forsberg合作论文数2harald zoebl合作论文数2Yukihiko Kitamura合作论文数2Maritta Kauppinen合作论文数2Masayuki Matsuda合作论文数2Helmut Fischer合作论文数2Günther Böck合作论文数2Fernando Ortiz合作论文数2Dolores Subira合作论文数2
Vincenzo Patella合作论文数UNIV NAPLES FEDERICO II,DIV CLIN IMMUNOL,FAC MED,I-80131 NAPLES,ITALY2Thomas Ruzicka合作论文数2
Josef Anrather合作论文数Neuroscience, Weill Cornell Graduate School of Medical Sciences, Cornell University2
Ichiro Katayama合作论文数Division of Dermatology, Osaka University;Osaka City University2
Tohru Tsujimura (辻村亨)合作论文数Department of Medicine, Faculty of Medicine, Hyogo Medical University;Graduate School of Medicine, Hyogo Medical University2
Kurt Zatloukal合作论文数Diagnostic and Research Center for Molecular Biomedicine, MUG2
Shintaro Nomura合作论文数Division of Physics, University of Tsukuba2Attila Dobozy合作论文数2
Marone Gianni合作论文数Dipartimento di Scienze Mediche Traslazionali, University of Naples Federico II;Centro Interdipartimentale di ricerca in Scienze Immunologiche di Base e Cliniche, University of Naples Federico II2Junichi Chihara合作论文数2Kiyoshi Nishioka合作论文数2
Yuji Matsuzawa (松澤佑次)合作论文数Division of Metabolic Medicine, Osaka University;Sumitomo Hospital2Olli Vainio合作论文数Department of Medical Microbiology, Turku University2Günter Michel合作论文数2Gabor Mehes合作论文数2
Yuzuru Kanakura合作论文数Department of Hematology and Oncology, Osaka University Graduate School of Medicine2
Daniel Candinas合作论文数2John W. Georgitis合作论文数2
