Alterations in neuraminidase activity can significantly affect neuronal processes. In our previous work, we demonstrated the formation of new synapses as a result of neuraminidase blockage. In the present study, we analyzed the effect of reduced endogenous neuraminidase activity on the synaptic efficacy of newly formed hippocampal synapses. Preincubation of slices with the N-acetyl-2,3-dehydro-2-deoxyneuraminic acid (NADNA) specific inhibitor resulted in a significant increase in the amplitude of synaptic responses, accompanied by reduced variability and a leftward shift of the input–output curves, suggesting an enhancement of excitatory connectivity within the CA3-to-CA1 hippocampal network.

Impaired synaptic plasticity is a hallmark of a number of neurological disorders successfully reproduced in animal models. Short-term forms of plasticity provide dynamic regulation of synaptic efficacy in response to various patterns of neuronal activity and largely depend on maintaining optimal conditions of the neuronal microenvironment, the key regulator of which is the blood–brain barrier (BBB). In recent years, the BBB has been considered an active participant in central nervous system homeostasis, and its dysfunction is recognized as a trigger for many neurological pathologies. We have developed an in vitro protocol that mimics the early consequences of BBB dysfunction by adapting the ionic composition of the incubation solution to blood plasma with the addition of thrombin. In the present study, we analyzed short-term synaptic plasticity in the hippocampal CA3-to-CA1 networks during the early phase following modeled BBB breakdown. Data obtained reveals significant alterations in short-term synaptic plasticity in the hippocampus under conditions of BBB dysfunction. We observed enhanced paired-pulse facilitation (PPF) at interstimulus intervals of 25 and 50 ms, suggesting a presynaptic locus for the changes in neurotransmitter release. Furthermore, a significant increase in the amplitude of post-tetanic potentiation (PTP) was recorded, indicating an increased reactivity of the CA3-to-CA1 neural networks. The selective enhancement of the early, activity-dependent phase of plasticity following high-frequency stimulation, in the absence of changes in the overall temporal dynamics, suggests a specific modulation of pattern-dependent short-term plasticity in BBB pathology. Induction of seizure-like activity of hippocampal neural networks has previously been demonstrated under identical conditions. Therefore, the present study characterizes specific alterations in synaptic properties due pathological condition formation that may ultimately lead to long-term consequences.

The article presents the results of studying the parameters of the cardiovascular system (CVS) in rats under conditions of ischemic-reperfusion simulation and exposure to electromagnetic radiation of extremely high frequency (EHF EMR). The aim was to identify changes in CVS parameters in rats during the postischemic period following preventive EHF exposure. The experiment was carried out on 30 mature male Wistar rats weighing between 200 and 220 g, which were housed in a vivarium under a natural light-dark schedule. Using a modified block randomization method, the animals were split into three groups with 10 rats in each: group 1 included sham-operated (SO) animals, which underwent surgery according to the operation plan but without occlusion of the left carotid artery; group 2 included truly operated animals who underwent surgery and had the left common carotid occluded (CCO) in accordance with the plan; and group 3 (EHF) included animals that underwent preventive 10-fold action of low-intensity EHF EMR followed by ischemia-reperfusion modelling (on the 10th day, after 60 min after the 10th session of EHF exposure) and OCA occlusion. It is shown that the modelled ischemia-reperfusion of the brain is associated with a strain of the physiological reserves of the CVS and the body as a whole. Thus, an increase in systemic blood pressure, heart rate, sympathetic effects on the CVS, energy costs, and oxygen consumption by cardiomyocytes is observed. Recovery of CVS indicators to the level of SO is observed on the 3rd day after ischemia. It was found that preventive 10-fold exposure to EHF mitigates the effect of ischemia, which is reflected in a decrease in all CVS indicators (except for PP). This increases adaptive capabilities of the body and accelerates recovery in post-ischemia, as well as promotes faster adaptation of physiological reserves to ischemic damage.

An analysis of changes in sensorimotor rhythms of the electroencephalogram (EEG) and features of the restoration of motor functions during a course of neurorehabilitation using a non-invasive brain-computer-hand exoskeleton interface was carried out in 50 children aged 7–15 years of both sexes suffering from cerebral palsy (CP). EEG was recorded in 32 leads under conditions of rest and kinesthetic imagination of hand extension movements. Depending on the success of the classifier program in determining imaginary states based on the EEG pattern, the children were divided into two groups—with high and low success when imagining movements. In children of the studied groups, when undergoing a course of neurorehabilitation, differences were revealed in the nature of changes in EEG amplitude in the sensorimotor mu (8–13 Hz) and beta (15–25 Hz) rhythms frequency ranges. When imagining movements of the right hand, intergroup differences for the mu rhythm reached the level of statistical significance in the medial electrodes of the fronto-central and parietal areas of the neocortex, for the beta rhythm—in the medial lead of the parietal region. Children in the group with high success showed a decrease or slight increase in the amplitude of the mu- and beta rhythm in these brain areas at the last session of the course compared to the first. We hypothesize that children in this group are not only better able to kinesthetically imagine movements throughout the course of neurorehabilitation, but also, based on feedback signals, learn to effectively adjust their strategies for movement imagination. Children in the group with low success showed an increase in the amplitude of sensorimotor rhythms in these brain areas, indicating the development of inhibition in the frontoparietal motor network. Patients, whose conditions were determined more accurately by the classifier, achieved higher rates of motor rehabilitation. The results of the study are important for clarifying the brain mechanisms of motor functions restoration in patients with cerebral palsy under the influence of a course of neurorehabilitation.

This work investigated the effect of low-intensity electromagnetic radiation of extremely high frequency (EMR EHF) on stress-induced changes in hematological parameters in rats. The isolated action of stress factors of varying intensity was shown to significantly change a number of hematological parameters of male rats, while their combined action with EMR EHF modifies the effects of isolated stress factors. Thus, under the conditions of hypokinetic stress (HS) relative to the control, the number of erythrocytes increased by 12.7% (p<0.05); under oxidative stress (OS), hematocrit values decreased by 19.0% (p<0.001); and under acute stress, the mean concentration of hemoglobin in erythrocytes increased by 22.6% (p<0.05). The effect of stress factors of various origins in combination with EMR EHF significantly changed the effects characteristic of isolated action of these stress factors. Thus, hypokinetic stress in combination with low-intensity electromagnetic radiation of extremely high frequency (HS-EHF) compared to HS reduced the number of erythrocytes by 11.0% (p<0.05) and the hemoglobin level by 11.2% (p<0.001), restoring these indices to the control level. The combined effect of OS-EHF neutralized the effect of hematocrit reduction in OS, although reducing the mean corpuscular volume and increased the mean corpuscular hemoglobin concentration by 24.3% (p<0.001) compared to the control. The number of leukocytes and lymphocytes decreased in OS and OS-EHF, while the combination of OS with EMR EHF weakened the stress-related damaging effect of OS.

We set out to examine the indicators of microhemodynamics and tissue oxidative metabolism in rats after their tenfold exposure to extremely high-frequency low-intensity electromagnetic radiation (EHF EMR). The aim was to elucidate the specifics of skin microcirculation and tissue oxidative metabolism following exposure to tenfold electromagnetic radiation of extremely high frequency. The experiment was carried out on 40 mature male Wistar rats weighing 200–220 g, which were kept in standard vivarium conditions under natural light regimen. The animals were divided into two groups with 20 rats each. The animals in the first group were biological controls and were exposed to false EHF EMR (placebo); the animals in the second group were exposed to mm-exposure in the morning, 10 sessions daily. On the 10th day of EMR exposure, the indicators of skin tissue fluorescence on the tail base were recorded. Tenfold exposure to low-intensity EHF EMR was shown to increase the concentration and intensity of NADH fluorescence, as well as the FAD and redox ratio. This indicates an increased cellular demand for ATP and the predominance of oxidative phosphorylation over other processes, thus demonstrating the activation of the respiratory chain. At the same time, an increase in endothelium-dependent vasodilation, a decrease in peripheral resistance, an increase in blood flow to the nutritive microvascular bed, and an improvement in venular outflow were observed in the microcirculatory bed. The conclusion is made that the modulating effect of EHF EMR is manifested in the rearrangements of correlations. Thus, the coefficient of variation comes to the fore – the final calculated indicator of microcirculation, which has strong negative associations with all indicators of tissue metabolism (FAD, NADH, RR). In addition, the amplitudes of endothelial rhythms associated with periodic releasing of nitric oxide by the endothelium show a strong negative association with FAD.

The neurotropic effects of cobalt and nickel salicylate were studied during perfusion of rat hippocampal sections with solutions of these salts at concentrations of 10-2 M, 10-3 M, 10-4 M and 10-6 M. The results of this study convincingly demonstrate that the formation of complex salts of acetylsalicylic acid with divalent metals cobalt and nickel leads to changes in neurotropic effects with varying degrees of severity. In the case of nickel salicylate, there is a decrease in the severity of the depressing neurotropic effect compared with acetylsalicylic and salicylic acids [16]. And in the case of cobalt salicylate at a concentration of 10-4 M, an activation effect is manifested. We believe that this is due to the influence of the whole complexon, since a high degree of stability is shown for cobalt salicylate, especially in an aqueous solution [10]. And this salt should remain fairly stable. In this regard, it is natural to assume that cobalt salicylate is capable of triggering other processes compared to acids and, perhaps, the mechanism of its action is less strongly associated with the COX system. The observed activation effect may be associated with a direct stimulating effect on the nerve cell and/or the result of synchronization of excitation in neural networks. It should be noted that the neurotropic effects of cobalt salicylate revealed in this work coincide in their orientation with the effect of this salt on the functioning of neurons of the subcaryngeal ganglia complex of the grape snail [10]. This indicates the uniformity of the mechanisms of influence of this salt on the nervous tissue of invertebrates and vertebrates. For nickel salicylate, only a weakening of the inhibitory effect is shown in comparison with the precursor acids, perhaps the stability constant of this salt is not high and its noticeable dissociation occurs. As a result, the released residues of acetylsalicylic acid will block COX, which will trigger a mechanism of neurotropic influence close to the effects of salt solutions, the effects of which were described earlier [16]. The contribution of nickel ions will be insignificant, because its mass fraction in the salt molecule is small. From the position of ionic mechanisms, we believe that the inhibition of the generation of total biopotentials by the studied salts is most likely associated with the suppression of the incoming sodium current. And the stimulating effect of cobalt salicylate in a concentration of 10-4 M, on the contrary, with its stimulation (relief). Also, the described effects can be realized as a result of modulation of synaptic interaction in neural networks. Elucidation of these biophysical mechanisms is a priority task of our further research. And also, the most important question remains open about the possible change in the effects of these salts with different injections of substances into the body: oral, intramuscular, intravenous, etc.

Introduction. The cutaneous blood circulation is a representative model both for studying the mechanisms of vascular diseases and for assessing the current state of the central hemodynamics in preclinical researches of various chemical compounds. Aim. The changes in the parameters of cutaneous microcirculation and central hemodynamics (heart rate and blood pressure) were studied in the animals under the action of acetylsalicylic acid and its coordination compounds with cations of cobalt, zinc, nickel and manganese at a dose of 20 mg/kg. Materials and methods. The research was conducted using the laser Doppler flowmetry method on the Lazma-MC device (manufactured by RPE Lazma, Russia) and the NIBP200A system (Biopac Systems, Inc., USA). Results. The study shows that animals develop bradycardia, and microcirculation and central hemodynamics change in two ways after the introduction of acetylsalicylic acid and the tested metal salicylates. These ways are hypotension-related hyperemia (acetylsalicylic acid and cobalt salicylate) and ischemia (zinc, nickel and manganese salicylates) associated with hypertension. Conclusion. The obtained data confirm the cardiotropic activity of new coordination compounds. The data also prove that the generation of the acetylsalicylic acid derivatives allows enhancing it physiological effects, as well as obtaining completely new molecules. The molecules are different from the precursor one and are necessary for the production of effective drugs.

The effect of acetylsalicylic acid (ASA) and its complex compounds with the metals lithium (Li+), potassium (K+), magnesium (Mg2+) and calcium (Ca2+) with a single intraperitoneal injection at doses of 5, 10 and 20 mg/kg on cardiovascular system (CVS) of rats (blood pressure, heart rate, indicators of heart electrocardiogram). The structure-effect analysis showed that the coordination compounds of ASA, in which, in addition to the ligand with bioactive properties, a metal-microelement is present, caused multidirectional changes in the CVS indices. Those changes depended both on the metal included in the compound and on the dose of the administered substance. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» (Department of Human and Animal Physiology and Biophysics, V.I. Vernadsky Crimean Federal University). The research of the biological effect of the acetylsalicylic acid, SLi+, SK+, SMg2+, SCa2+ was carried out during their intraperitoneal injection into rats in doses of 5, 10 and 20 mg/kg. Simultaneously the following characteristics of all the groups’ animals were registered: heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) and electrocardiogram indicators. The pulse pressure (PP) was calculated on the basis of the SBP and DBP indices difference. BP, HR and RR of the rats were registered with the help of the system NIBP200A («Biopac Systems, Inc.», USA). The experimental data obtained in our studies confirm the literature data, which show that in the process of complexation there is not only an increase or decrease in certain effects that are characteristic of precursor molecules-salicylates, but also the appearance of new properties of derived substances. Тhe obtained data confirm the cardiotropic effectiveness of new coordination compounds, show the dose dependence of these effects and open up the prospects for further studies of their biological action when used repeatedly in chronic experiments.

The effect of acetylsalicylic acid and acetylsalicylates ofcobalt (Co2+), zinc (Zn2+),nickel (Ni2+) and manganese (Mn2+)at doses of 5 and 10 mg/kg on rat tissue microhemodynamics was studied.It was established that the coordination complexes of metal salicylatesdemonstrate novel properties and a more pronounced biological effectcompared to a parent compound, acetylsalicylic acid. This favorsfurther search for biological and pharmacological activities among newlysynthesized coordination complexes of acetylsalicylic acid.

The effect of acetylsalicylic acid and its complex compounds with metals (cobalt, zinc, nickel and manganese) at a dose of 10 mg/kg for 20 days on rat skin microhemodynamics was studied. It was established that acetylsalicylic acid and tested salicylates effectively modulated the skin microcirculation indices in the experimental animals. It depended on the metal in the injected compound composition and on the duration of tested salicylates administration. This demonstrated the cumulative effect of metal salicylates.

The effect of acetylsalicylic acid and its complex compounds with the metals cobalt (Co2+), zinc (Zn2+), nickel (Ni2+) and manganese (Mn2+) at doses of 5, 10 and 20 mg/kg on the parameters of the rat cardiorespiratory system was studied. It is shown that in the process of complexation of acetylsalicylic acid with bimetals, there is not only an increase or decrease in certain effects inherent in the precursor molecule – acetylsalicylic acid, but also the appearance of new properties, the manifestation of which is dose-dependent. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» of the Department of Human and Animal Physiology and Biophysics of the V. I. Vernadsky Crimean Federal University. The research of the biological effect of the acetylsalicylic acid, АСCo2+, АСZn2+, АСNi2+, АСMn2+was carried out during their intraperitoneal injection into rats in doses of 5, 10 and 20 mg/kg. Simultaneously the following characteristics of all the groups’ animals were registered: heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The pulse pressure (PP) was calculated on the basis of the SBP and DBP indices difference. BP, HR and RR of the rats were registered with the help of the system NIBP200A («BiopacSystems, Inc.», USA). The experimental data obtained in our studies confirm the literature data, which show that in the process of complexation there is not only an increase or decrease in certain effects that are characteristic of precursor molecules-salicylates, but also the appearance of new properties of derived substances. This suggests that certain biological effects of salicylates may be associated with interaction with metalloenzymes. Thus, the obtained data confirm the cardiotropic effectiveness of new coordination compounds, show the dose dependence of these effects and open up the prospects for further studies of their biological action when used repeatedly in chronic experiments.

The paper studies the identification of the acetylsalicylic acid (ASA) effects and salicylates of cobalt and nickel at different doses from 5 mg/kg to 20 mg/kg (increase step by step 5 mg/kg) by patterns muscle activity of needle electromyography (EMG) in rats. The analysis of the parameters needle electromyogram showed that after the injection of ASA at different doses most significant increase of the maximum and total amplitudes, average frequency, and minimum duration of PMU is observed. It is also noted that the growth of spectral parameters indicates an increase in the degree of impulses synchronization of different motor units. When rats were injected with ACNi2+, EMG, indices changed in the similar way, but less significantly. The injection of ACCo2+ at a dose of 5 g/kg in animals caused a significant increase of the main indicators of the turn-amplitude analysis in comparison with the control group values. The injection of this compound at doses of 10 and 20 mg/kg caused a significant decrease in the studied EMG parameters; this indicates the decrease in the motor neurons activity.

The antiulcerogenic effectiveness of the low-intensity electromagnetic radiation of the millimetric range was studied in the model of chronic hypokinetic stress. It was found out that chronic hypokinetic stress causes the development of the ulcerogenesis, the intensity of which depends on the duration of the stress factor, which for animals is being in hypokinesia. Along with this, the maximum ulcerogenic damages are registered after 10 days of the mobility restriction; this is evident by the increase of the affected animals’ number, and by the growth of Pauls’ index by 586 % (p≤0.05) in comparison with the first day of the mobility restriction. The application of the low-intensity electromagnetic radiation of the millimetric (mm) range has the gastroprotective effect in the conditions of hypokinesia. The effect depends on the length of the impact, the maximum ulceroprotective effect was observed after the ten-fold mm-impact: the number of the affected animals decreases by 50 %, Pauls’ index decreases by 70 % (p≤0.05) in relation to the same in the group of animals, having undergone the hypokinesia, and the index of antiulcerogenic activity of mm-impact was 3.3, (>2), this indicates the occurrence of the antiulcerogenic activity of the mm-radiation.

A Correction to this paper has been published: https://doi.org/10.1134/S0022093021020216

The article presents the results of evaluation of analgesic and anti-inflammatory activity of the adduct of 1-hydroxy-1,1-ethylidendiphosphonic acid and bis(2-pyridyl-1,2,4-triazolyl-3)propane (HEA+BPP) in male rats with a 21-day course administration. The aim of the study was to evaluate analgesic and anti-inflammatory activity in male rats with 21-day course administration of HEA+BPP course administration with 21-day course administration. The animals were divided into 7 groups of 10 individuals. Analgesic activity of HEA+BPP was tested on 40 males, and anti – inflammatory activity was tested on 30 others. In studies of analgesic activity of HEA+BPP, males of one group were control and received intraperitoneal injections of 0.2 ml of saline solution every day at 10.00 for 21 days, the others groups received 0.2 ml of intraperitoneal injections of HEA+BPP at doses of 5, 50 and 100 mg/kg at the same time for 21 days. In analgesic studies, groups of animals were similarly formed, when testing the anti-inflammatory effect of HEA+BPP, only without injecting a dose of 100 mg/kg. HEA+BPP synthesized at the Department of General and inorganic chemistry of the faculty of biology and chemistry of the Tauride Academy (structural division) of the V. I. Vernadsky Crimean Federal University. The chemical purity of HEA+BPP was at least 98 %. The analgesic activity of HEA+BPP was evaluated by the parameters of pain sensitivity of animals in the background and 1 hour after intraperitoneal injections on the 1st, 6th, 10th, 14th and 21st days of the experiment in the models of acute pain stress «tail-flick», Randall-Sellitto and «hot plate». Before the tail-flick and Randall-Sellitto tests were performed, the animals were placed in special rat retainers after injection. The anti-inflammatory activity of HEA+BPP was evaluated in the formalin paw edema test in rats. Acute inflammatory response was reproduced by subplantar injection of 0.1 ml of 2 % formalin solution in the form of an aqueous solution into the left hind leg of a rat, and then the value of limb edema was measured using the method of water plethysmometry on the 10th and 21st days of course administration of HEA+BPP in doses of 5 and 50 mg/kg. The data are presented as mean and standard error mean, statistical analysis performed using the software packages StatSoft/STATISTICA 8 and Graph Pad Prism 7.0. The significance of differences between groups was determined using one-way analysis of variance (ANOVA) with post hoc test Tukey and non-parametric criterion of multiple comparisons of Dunn, according to official methodological recommendations on statistical treatment of the results of preclinical studies of medicines, given in the literature. During course administration to male rats of HEA+BPP for 21 days in the dose range from 5 to 100 mg / kg, it was found that this compound mainly demonstrates effectiveness as an analgesic with a single injection, only for mechanical pain, this substance is effective with a course administration at a dose of 5 mg/kg: The «tail-flick» test showed, that using of HEA+BPP as an analgesic involved in the spinal mechanism of pain sensitivity regulation is advisable in doses of 5, 50 and 100 mg/kg only with a single injection: latent period of the reaction discharge of the tail increased relative to control at a dose of 5 mg/kg on the 1st day of administration of HEA+BPP by 32.7 % (p≤0.05), at a dose of 50 mg/kg on the 1st and 21st days of administration – by 40 % (p≤0.01) and 67.1 % (p≤0.001) and at a dose of 100 mg/kg on the 1st day of administration – by 80.0 % (p≤0.01), respectively. At a dose of 5 mg/kg on the 10th day of administration, on the contrary, was discovered algogenic effect of HEA+BPP (latent period of the reaction discharge of the tail was significantly decreased relative to control by 24.1 % (p≤0.01). In the test of Randall-Selitto the efficiency of single use HEA+BPP as an analgesic in mechanical pain at doses of 50 and 100 mg/kg (pain threshold was significantly increased relative to control at 25.2 % (p≤0.01) and 80 % (p≤0.01), and in course administration only at a dose of 5 mg/kg (pain threshold was significantly increased relative to control at 55.3 % (p≤0.001), 72.5 % (p≤0.001) and 49.6 % (p≤0.01) on the 6th, 14th and 21st day of the course introduction). The «hot plate» test shows the feasibility of only a single use of HEA+BPP as an analgesic in doses of 5 and 50 mg/kg, since these effects were unstable and unstable when administered on a course basis. The «formalin test» revealed the inflammatory and exudative effect of HEA+BPP at a dose of 5 mg/kg, in which HEA+BPP on the 21st day of administration increased the formalin edema of the rat paw by 70.9 % (p≤0.01).

In contrast to the development of muscle adaptations associated with overstrain, insufficient stretching, overloading, and underloading, use of short-term courses of low-strain motor-cognitive training induces adaptation linked with neural rearrangements, studies of which are of great interest. This direction remains insufficiently studied as indicated, for example, by the fact that motor activity regimes in medical rehabilitation are selected empirically and the difficulty of prognostication and assessment of rehabilitation potential. In these studies, 25 healthy pretrained volunteers applied force to an immobile joystick with the hand to control a label on a screen with the aim of studying the ability to follow instructions and the force characteristics of low-amplitude control movements. A joystick attached to a force platform was used to assess measures of the trajectory of the center of pressure on the support, the vertical force, and the external result (the extent of following the instruction in terms of the mean duration of processing a single result) on performance of a standard task with visual feedback carried out three times with each hand sequentially over four days (short training course). Data were analyzed using standard mathematical methods. A stable level of following instructions was achieved extremely quickly – by the second session. Optimization of vertical pressure force occurred during the second course, while optimization of control in the plane of the support was more difficult. “Optimization” of motor control (for a given observation period) and adaptive processes proceeded nonuniformly for different aspects of control: achievement of optimal productivity, selection of vertical force, and manipulation of force in the plane of the support. The rapid improvements in results obtained from following instructions were presumptively linked with optimization of the strategy. The task of optimizing vertical force on the joystick was more difficult, while the most difficult was control of hand force in the plane of the support, which may be associated with the fact that this was linked with a later stage of training.

The article provides an overview of scientific works devoted to methods of correcting the development of children with autism spectrum disorders (ASD) based on EEG biofeedback (neurofeedback). According to the World Health Organization, one in 160 children are currently diagnosed with ASD. In 2018, about 0.1 % of the child population in Russia suffered from autism. Moreover, the incidence of the disease is increasing every year. Genetic disorders are the most likely cause of ASD. Dysfunctions of 69 genes are highly likely to cause ASD. Most of these genes are pleiotropic. They affect the proliferation, differentiation and migration of nerve cells, the growth of axons and synaptogenesis, the synthesis of neurotransmitters and the development of receptors for them. Several genes involved in the development of ASD undergo epigenetic modifications under the influence of the environment and pathogens. The key in the onset of ASD is probably a violation of the synaptic pruning process. Pruning is necessary to reduce redundant connections and improve the efficiency of the central nervous system. Based on this, the researchers put forward a hypothesis explaining the symptoms of ASD as a result of a violation of structural and functional brain connectivity. Such disturbances are likely to cause abnormalities in the functioning of the brain mirror system (BMS). Disorders of the synaptic organization of the brain correlate with indicators of cognitive, emotional and behavioral tests, EEG characteristics. The study of phase coherence in several EEG frequency ranges demonstrated the presence of global hypo- and local hyper-connectivity in patients with ASD. The absence of suppression or desynchronization of the mu rhythm may indicate a malfunction of the BMS. The child’s brain is highly plastic. Therefore, early corrective intervention can improve the developmental outcomes of a child with ASD. Modern research demonstrates the possibility of effective application of neurofeedback for the correction of the disease. One of the strategies is the use of neurofeedback trainings to reduce anxiety in children with ASD. Another strategy is aimed at regulating the coherence of EEG signals. Researchers consider the most promising strategy for learning mu rhythm modulation using neurofeedback. This neurofeedback protocol affects the functioning of the BMS. According to the research results, after the neurofeedback trainings, the normalization of the functional cerebral connectivity according to the mu rhythm was established. Further research in this direction can become the basis for the most effective methods of treating ASD.