Potassium deficiency was produced in 16 dogs by means of a diet containing less than 0.03% potassium. Decreases in serum potassium were first observed after 3 weeks. Morphologic changes occurred only in heart, skeletal muscle, and kidney. Focal myocardial necrosis was observed in 6 of 16 deficient dogs, and skeletal muscle degeneration and necrosis were observed in 14 of 16 deficient dogs. A complex nephropathy consisting primarily of epithelial hypertrophy and hyperplasia in the collecting tubules of the inner stripe of the outer medulla occurred in all the deficient dogs.

British Journal of Clinical PharmacologyVolume 4, Issue S1 p. 19S-29S Free Access Pharmacology and toxicology of diflunisal. CA Stone, CA StoneSearch for more papers by this authorCG Van Arman, CG Van ArmanSearch for more papers by this authorVJ Lotti, VJ LottiSearch for more papers by this authorDH Minsker, DH MinskerSearch for more papers by this authorEA Risley, EA RisleySearch for more papers by this authorWJ Bagdon, WJ BagdonSearch for more papers by this authorDL Bokelman, DL BokelmanSearch for more papers by this authorRD Jensen, RD JensenSearch for more papers by this authorB Mendlowski, B MendlowskiSearch for more papers by this authorCL Tate, CL TateSearch for more papers by this authorHM Peck, HM PeckSearch for more papers by this authorRE Zwickley, RE ZwickleySearch for more papers by this authorSE McKinney, SE McKinneySearch for more papers by this author CA Stone, CA StoneSearch for more papers by this authorCG Van Arman, CG Van ArmanSearch for more papers by this authorVJ Lotti, VJ LottiSearch for more papers by this authorDH Minsker, DH MinskerSearch for more papers by this authorEA Risley, EA RisleySearch for more papers by this authorWJ Bagdon, WJ BagdonSearch for more papers by this authorDL Bokelman, DL BokelmanSearch for more papers by this authorRD Jensen, RD JensenSearch for more papers by this authorB Mendlowski, B MendlowskiSearch for more papers by this authorCL Tate, CL TateSearch for more papers by this authorHM Peck, HM PeckSearch for more papers by this authorRE Zwickley, RE ZwickleySearch for more papers by this authorSE McKinney, SE McKinneySearch for more papers by this author First published: February 1977 https://doi.org/10.1111/j.1365-2125.1977.tb04510.xCitations: 58AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. 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We investigate the problem of statistical analysis of interval-valued time series data - two nonintersecting real-valued functions, representing lower and upper limits, over a period of time. Specifically, we pay attention to the two concepts of phase (or horizontal) variability and amplitude (or vertical) variability, and propose a phase-amplitude separation method. We view interval-valued time series as elements of a function (Hilbert) space and impose a Riemannian structure on it. We separate phase and amplitude variability in observed interval functions using a metric-based alignment solution. The key idea is to map an interval to a point in R2 , view interval-valued time series as parameterized curves in R2 , and borrow ideas from elastic shape analysis of planar curves, including PCA, to perform registration, summarization, analysis, and modeling of multiple series. The proposed phase-amplitude separation provides a new way of PCA and modeling for interval-valued time series, and enables shape clustering of interval-valued time series. We apply this framework to three different applications, including finance, meteorology and physiology, proves the effectiveness of proposed methods, and discovers some underlying patterns in the data. Experimental results on simulated data show that our method applies to the point-valued time series.

Lesions induced by aspirin in the small intestine of the rat were visualized after 4 hours by the intravenous administration of a 5 percent solution of pontamine sky blue, 6 BX dye. Dose-response curves in fasted and fed rats indicated that the fed rat was about eight times more susceptible to aspirin-induced intestinal damage than was the fasted rat, while the fasted rat was about 13 times more susceptible to aspirin-induced gastric damage than was the fed rat.