1. Boynton GE, Stem MS, Kwark L, Jackson GR, Farsiu S, Gardner TW. Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure. Ophthalmology. 2015;122:957-967. 2. Fong DS, Girach A, Boney A. Visual side effects of successful scatter laser photocoagulation surgery for proliferative diabetic retinopathy: a literature review. Retina. 2007;27:816-824. 3. Gross JG, Glassman AR, Jampol LM, et al. Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy. JAMA. 2015;314:2137-46. • Fifteen adults with untreated PDR and visual acuity > 20/32 underwent Farnsworth color vision testing, Minnesota Reading Test, PelliRobson contrast sensitivity, 24-2 Frequency Doubling Perimetry (FDP, Carl Zeiss Meditec, Dublin, CA), photostress testing, dark adaptation (AdaptRx, MacuLogix, Inc, Hummelstown, PA), 10-2 and 60-4 Humphrey Visual Fields (Carl Zeiss Meditec), spectral domain Optical Coherence Tomography (SDOCT, Heidelberg Engineering, Heidelberg, Germany), and color fundus photography (Optos, Dunfermline, United Kingdom) before and 10 months after PRP. • Paired Wilcoxon signed-rank testing was used to compare performance before and after PRP. • Significance threshold was adjusted to 0.05/68 = 0.00068 to account for multiple testing, according to the Bonferroni correction. • The effects of pan-retinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR) on macular structure and function are incompletely understood.1,2,3 • Recent studies comparing the safety of PRP versus anti-VEGF injections highlight the importance of understanding the effect of PRP on the macula.1,3 • After the Bonferroni correction, we found mean macular function and structure to be preserved at one year after PRP. • Individual results were heterogeneous, with patients having changes in different subsets of tests. • Tests of outer retinal function appeared to be more affected than tests of inner retinal function. • Mean performance on 60-4 peripheral visual fields were preserved at follow-up. • The inner superior and inner nasal quadrants of the inner nuclear layer were statistically significantly thicker following PRP, but the difference was only by 3.3 μm. • Further studies are needed to evaluate longterm impact of PRP on the retina. 6347-C0134
Thomas Gardner合作论文数Medical School, University of Michigan-Ann Arbor4
Stem Maxwell S合作论文数4Grace E. Dunbar合作论文数3Davila Jose合作论文数School of Public Health, University of Michigan3Vinícius M de Castro合作论文数2Kwark Leon合作论文数2
Sina Farsiu合作论文数Department of Biomedical Engineering, Pratt School of Engineering, Duke University;Department of Ophthalmology, Duke University School of Medicine2Grace E Boynton合作论文数1Sejal Amin合作论文数1Amanda Milliken合作论文数1
Katherine Joltikov合作论文数1
Maria A. Woodward合作论文数W.K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, Medical School, University of Michigan1
Paula Anne Newman-Casey合作论文数Department of Ophthalmology and Visual Sciences, Medical School, University of Michigan-Ann Arbor1
Rodica Pop-Busui合作论文数Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, Medical School, University of Michigan-Ann Arbor1
Gui-shuang Ying合作论文数Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania1Ebenezer Daniel合作论文数Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania1
Mamta Jaiswal合作论文数Colorado Sch Publ Hlth Dept Epidemiol Aurora1Maureen G. Maguire合作论文数1Gregory R. Jackson合作论文数1
