Application of postharvest fungicides is a highly effective, targeted, and economical way to protect fruit from decay after harvest including during shipment and marketing with proper application methods, fungicide residues remain within maximum residue limits, similar to levels found after preharvest field applications. The United States have been on the forefront in developing these treatments. For sub-tropical crops such as citrus, pomegranates, pineapples, and avocados, new fungicides have been introduced to manage major diseases. They represent different FRAC (Fungicide Resistance Action Committee) groups ranging from conventional (propiconazole), reduced-risk (pyrimethanil; azoxystrobin; fludioxonil) to bio-pesticide (natamycin) compounds, and also include pre-mixtures (fludioxonil-propiconazole, -azoxystrobin, and -cyprodinil). Selection and development of these fungicides has been done gradually as products designated safer by the United States Environmental Protection Agency were identified that maintain high performance, use low rates, and have broad-spectrum activity similar to previous standards. Natamycin, a fermentation product of Streptomyces spp., is exempt from tolerance in North America, it potentially may be certified as an organic treatment, and resistance has not been reported in filamentous fungi in over 30 years of use. This may prove crucial in the management of Penicillium spp. and other postharvest decays of subtropical crops. Although moderately effective by itself, mixtures provide high efficacy and resistance management.