BACKGROUND:The impact of mononuclear cell infiltration on renal cell carcinoma (RCC) biology has been controversial, previously reported to be associated with either a favorable or unfavorable prognosis. The objective of the current study was to evaluate associations between mononuclear cell infiltration in routinely prepared paraffin-embedded specimens with survival in patients with clear-cell RCC.METHODS:A total of 306 patients were identified treated with nephrectomy for clear-cell RCC between 1990 and 1994. A single urologic pathologist, blinded to patient outcome, reviewed the specimens and quantified the extent of mononuclear cell infiltration as absent, focal, moderate, or marked. Cancer-specific survival was estimated using the Kaplan-Meier method. Associations of mononuclear cell infiltration with death from RCC were assessed using Cox proportional hazards regression models.RESULTS:At last follow-up, 173 of the 306 patients studied had died, including 96 patients who died from RCC. Mononuclear cell infiltration was absent in 165 (54%), focal in 70 (23%), moderate in 53 (17%), and marked in 18 (6%). Univariately, patients with specimens that had mononuclear cell infiltration were over 2 times more likely to die from RCC compared with patients whose specimens exhibited no mononuclear cell infiltration (risk ratio, 2.63; P < .001). After adjusting for the Mayo Clinic SSIGN (stage, size, grade, and necrosis) score, patients with specimens that had mononuclear cell infiltration exhibited a significantly increased likelihood of dying from RCC compared with patients whose specimens had no mononuclear cell infiltration (risk ratio, 1.61; P = .028).CONCLUSIONS:Mononuclear cell infiltration is associated with death from RCC even after multivariate adjustment. Routine documentation of mononuclear cell infiltration is recommended during the pathologic assessment of RCC.

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 24, 2005, 8:00 am - 12:00 pm1 Apr 2005965: Erythrocyte Sedimentation Rate: An Independent Prognostic Feature of Clear Cell Renal Cell Cancer Shomik Sengupta, Christine M. Lohse, Demetrius Dicks, Bradley C. Leibovich, John C. Cheville, Horst Zincke, Michael L. Blute, and Eugene D. Kwon Shomik SenguptaShomik Sengupta More articles by this author , Christine M. LohseChristine M. Lohse More articles by this author , Demetrius DicksDemetrius Dicks More articles by this author , Bradley C. LeibovichBradley C. Leibovich More articles by this author , John C. ChevilleJohn C. Cheville More articles by this author , Horst ZinckeHorst Zincke More articles by this author , Michael L. BluteMichael L. Blute More articles by this author , and Eugene D. KwonEugene D. Kwon More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35121-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "965: Erythrocyte Sedimentation Rate: An Independent Prognostic Feature of Clear Cell Renal Cell Cancer." The Journal of Urology, 173(4S), p. 261 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 261 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Shomik Sengupta More articles by this author Christine M. Lohse More articles by this author Demetrius Dicks More articles by this author Bradley C. Leibovich More articles by this author John C. Cheville More articles by this author Horst Zincke More articles by this author Michael L. Blute More articles by this author Eugene D. Kwon More articles by this author Expand All Advertisement PDF downloadLoading ...

PURPOSE:Eosinophilic cystitis is a rare disorder, with fewer than 30 pediatric cases reported in the literature. We describe our experience with pediatric eosinophilic cystitis during a 20-year period.MATERIALS AND METHODS:Four children referred to our institution were subsequently diagnosed with eosinophilic cystitis between 1984 and 2004. A retrospective chart review was performed to assess clinical presentation, diagnosis, treatment and outcomes.RESULTS:Mean patient age at presentation was 10.8 years (range 5 to 18) and male-to-female ratio was 3:1. All 4 patients presented with irritative urinary symptoms, including 3 with dysuria and/or gross hematuria and 2 with urinary frequency, lower abdominal pain and/or a concomitant urinary tract infection. Allergic diseases (asthma, allergic rhinitis, etc) were present in 3 patients, and a formal allergen skin test was positive in 2 of those tested. A bladder mass mimicking malignancy was documented in 2 patients. Three patients had symptom resolution with conservative treatment, while 1 had development of an unremitting tumefactive process that eventually required partial cystectomy and bladder augmentation.CONCLUSIONS:Eosinophilic cystitis is a rare condition with a wide range of clinical manifestations. Children can present with a bladder mass mimicking sarcoma, underscoring the need for biopsy before diagnosis and treatment of a presumed oncological process. The condition usually follows a benign course, although unremitting progression remains a possibility.