Editor,—Primary yolk sac tumour of the mediastinum is a rare germ cell tumour. Sporadic case reports document the presenting features of chest pain, cough, shortness of breath, and superior vena cava syndrome. To our knowledge, this is the first case to present with Horner's syndrome. ### CASE REPORT A 23 year old man was referred with anisocoria. For 3 months the left pupil had been noted to be smaller than the right although the patient reported it enlarged significantly after he took amphetamine tablets. …

Editor,—Familial amyloidosis of the Finnish type (FAF), also known as Meretoja syndrome, is a rare autosomal dominant disorder first described by Meretoja in 1969.1 It is thought to develop as a result of a single point mutation involving the gelsolin gene located on chromosome 9. The estimated total number of patients in Finland is 400. Approximately 15 cases have been described outside Finland.2 We present the first case to be recognised in the UK demonstrating the classic signs of corneal lattice dystrophy, cranial neuropathy, and skin changes with an autosomal dominant pedigree. ### CASE REPORT A 73 year old woman presented with gradual reduction in visual acuity in her left eye. She had suffered recurrent corneal erosions affecting her left eye and was diagnosed as having corneal …

Gene amplification by the polymerase chain reaction (PCR) is useful in ophthalmic diagnosis since it enables exceedingly small amounts of nucleic acid to be detected in ocular samples. Studies have indicated a potential for the use of PCR on ocular specimens to assist the clinical diagnosis of ocular toxoplasmosis.' We describe a case in which the technique was used in the diagnosis of acquired ocular toxoplasmosis in an immunocompetent adult.