The modern era has witnessed both the triumphs of the first resectional procedures for pancreatic cancer and the failures of most of these operations to cure [1–4]. Similarly, it has seen optimistic first reports and less sanguine follow-ups of various adjunctive radiation therapy and chemotherapy regimens [5–11]. This chapter will briefly review these landmarks and will then cover modern management for the patient with carcinoma of the exocrine pancreas.
