Journal Article Pigmentary changes in pernicious anaemia: an important but under‐recognized phenomenon Get access A. C. Sherley‐Dale, A. C. Sherley‐Dale Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J. M. R. Goulding, J. M. R. Goulding Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J. Leithead, J. Leithead Gastroenterology, University Hospital Walsgrave, Coventry, CV2 2DX, UK E‐mail: drgoo@btinternet.com Search for other works by this author on: Oxford Academic Google Scholar D. E. Loft, D. E. Loft Gastroenterology, University Hospital Walsgrave, Coventry, CV2 2DX, UK E‐mail: drgoo@btinternet.com Search for other works by this author on: Oxford Academic Google Scholar I. Ahmed I. Ahmed Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 36, Issue 1, 1 January 2011, Pages 93–95, https://doi.org/10.1111/j.1365-2230.2010.03793.x Published: 01 January 2011

Percutaneous endoscopic insertion of gastrostomy tubes is a technique becoming more widely used in the UK. It allows insertion of a gastrostomy tube without laparotomy, under local anaesthesia and sedation, and so operative insertion may eventually become a rarity. We report on our successful early experience with a new gastrostomy tube (Bower PEG) which does not require endoscopy if eventual removal is required, and describe the methods of insertion and removal.

One hundred and sixty-two of 182 patients with coeliac disease provided satisfactory details of family size and the prevalence of coeliac disease and inflammatory bowel disease among their first-degree relatives. Patients ranged in age from 11 months to 79 years with a mean age of 41 (+/- 23) years. Twenty patients had at least one first-degree relative with coeliac disease: a total of 25 of 861 relatives were affected (prevalence = 2904/100,000) compared with an expected 0.9 cases (prevalence = 100/100,000; p less than 0.001). Six relatives had inflammatory bowel disease (prevalence = 697/100,000) compared with an expected 1.3 cases (prevalence = 150/100,000; p less than 0.001). Five of these had ulcerative colitis, and one had Crohn's disease. The relative risk of ulcerative colitis is, therefore, five times greater for first-degree relatives of people with coeliac disease than for the general population (95 per cent confidence interval, 4.7-7.2). There is a clear association between coeliac disease and ulcerative colitis, which may point to factors involved in the aetiology of colitis.