The synthesis of a DNA-PHONA-PNA chimeric molecule using the Mmt protection strategy is described. The chimeric oligomer shows duplex binding properties that are comparable to PNA. Obviously, PHONA building blocks can be incorporated into PNAs without distortion of the PNA. structure.

The synthesis of polyamide nucleic acids (PNAs) and derivatives thereof by different synthetic routes is described. The first strategy makes use of 9-Fluorenylmethoxycarbonyl (Fmoc)/monomethoxytrityl (Mmt) protected building blocks, whereas the second approach involves the use of Mmt/acyl protected monomers, which allows the preparation of PNA/DNA chimera. Additionally, a block coupling strategy is presented for the synthesis of novel phosphonic ester nucleic acids (PHONAs).

Unambiguous binding to complementary DNA and RNA, stability toward 3′-exonucleases, and a similar uptake by cells as DNA oligomers characterize the PNA/DNA chimeras of type 1 described here. These chimeric oligomers are accessible in an automated synthesis sequence.

The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is described. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for the exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptameric and octameric PNAs.

[AlaB5]Insulin as well as a hybrid analogue of insulin and "insulin-like growth factor" (IGF-I), in which the N-terminal amino-acid sequence H-Phe-Val-Asn-Gln- of the B-chain has been replaced by the tripeptide H-Gly-Pro-Glu-of IGF-I, have been prepared by the partial-synthetic route. Their biological activity in vivo has been compared with that of other analogues in rabbits, mice and rats as far as data are available. These rodents respond differently, rats being less sensitive to modifications than rabbits and mice. The results explain unexpected discrepancies discussed in previous papers.

Stepwise Edman degradation of the insulin B chain is achieved after reversible protection of the amino groups in A1 and B29 with the acid-stable methylsulfonylethyloxycarbonyl residue. Condensation of the protected N-terminal tetrapeptide of insulin-like growth factor I with the degraded insulin yields an hybrid insulin whose synthesis and biological properties are discussed.

Substitution of A1-glycine of insulin by L-amino acids yields in analogues with low biological activity. With D-amino acids in A1 biological activity is essentially retained. The influence of aliphatic, aromatic, acidic and basic alpha-D-amino acids as well as omega-amino acids in A1 on the biological effects in different test systems is studied and discussed.

AbstractDurch Reaktion von Pyridin mit den Zn‐Komplexen (Ia) bzw. (Ib) bei Rückflußtemperatur des Pyridins bilden sich die Komplexe (II) bzw. (III).

According to equations (1) and (2) new bis(organosulfinato)mono and bis(pyridine) complexes of zinc with coordination numbers 4, 5 and 6 are described. The structures are discussed pn the basis of the IR spectra of the compounds.

Article Insulin-Analoga mit N-terminal verkürzter B-Kette. Selektiver Edman-Abbau an der B-Kette des Insulins was published on January 1, 1973 in the journal Biological Chemistry (volume 354, issue 2).

Angewandte ChemieVolume 82, Issue 3 p. 133-134 Zuschrift Metall-Ligand-Bindung in Sulfinato-Komplexen von Übergangsmetallen Priv.-Doz. Dr. E. Lindner, Priv.-Doz. Dr. E. Lindner Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorDr. G. Vitzthum, Dr. G. Vitzthum Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorDipl.-Chem. D. Langner, Dipl.-Chem. D. Langner Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorcand. chem. I.-P. Lorenz, cand. chem. I.-P. Lorenz Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this author Priv.-Doz. Dr. E. Lindner, Priv.-Doz. Dr. E. Lindner Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorDr. G. Vitzthum, Dr. G. Vitzthum Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorDipl.-Chem. D. Langner, Dipl.-Chem. D. Langner Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this authorcand. chem. I.-P. Lorenz, cand. chem. I.-P. Lorenz Institut für Anorganische Chemie der Universität Erlangen-Nürnberg 8520 Erlangen, Fahrstraße 17Search for more papers by this author First published: Februar 1970 https://doi.org/10.1002/ange.19700820305Citations: 12AboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume82, Issue3Februar 1970Pages 133-134 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation

AbstractDie zum Teil bereits beschriebenen Sulfinato‐Komplexe (I) erhält man aus den Natriumsulfinaten und den entsprechenden löslichen Metallsalzen.

Durch Umsetzung von CF3CSSH mit BrMn (CO)5 und BrRe (CO)5 bei 50° in Dimethyläther gemäß BrM (CO) 5+CF3CSSH → CF3CSSM (CO) 4 + CO + HBr (M = Mn, Re) gelingt die Darstellung der kovalenten, z. T. sublimierbaren, thermisch und gegen Luftsauerstoff recht stabilen Tetracarbonyl-trifluordithioacetate des Mangans und Rheniums. Die Komplexe werden IR-spektroskopisch charakterisiert, wonach ihnen C2v -Symmetrie zukommt.