Prolonged exposure even to suberythemal UV doses has many associated risk factors, including skin cancer and photo-aging. Recent studies also indicate that high-energy visible light (HEV) induces oxidative stress in the skin which is ultimately linked to visible signs such as pigmentation and aging. Personalized monitoring of UV/HEV radiation is necessary for recommendations of personal sun-safe behaviors. Here, we demonstrate a wireless, battery-free, miniature, wearable UV/HEV sensor that can be mounted on t-shirt, sunglasses, wristband, shoes or necklace. The sensor is the first electronic UV/HEV dosimeter that measures true cumulative UV/HEV exposure that is directly comparable to skin exposure. It also operates as a personalized digital skin coach that provides user with actionable data and recommendations to improve skin health. We run several clinical evaluation studies to demonstrate functionality of the sensor. One study involved healthy volunteers engaged in recreational activities. Subjects wore devices on the thumbnail or the middle fingernail, while they participated in causal activities including playing games, showering, swimming with use of skin care product. Another study demonstrated that measurements from different body locations can be used to extrapolate total body UV/HEV exposure. The studies demonstrated sensor accuracy, reliability, and versatility. They also showed that measurements of UV/HEV exposure from different body locations can be used for reliable estimations of personal UV/HEV exposures.

Skin exposure to solar radiation can cause many adverse effects. In addition to the sun protection factor (SPF), a parameter associated with Ultraviolet B (UVB) protection, significant evidence emphasized the crucial importance of a well-balanced protection against ultraviolet A (UVA) and for some indications, against high-energy visible light. Synergy between UV filters and filter photostability together with film-forming ingredients such as polymers that ensure the homogeneous distribution of UV filters on the skin are key factors to avoid UVA- and UVB-provoked detrimental effects of solar radiation. Clinical studies mimicking real conditions of use have been performed. The results show that a well-balanced sunscreen with at least an SPF-to-UVA protection factor ratio < 3 provides the most effective protection against DNA damage, skin photoimmunosuppression, photodermatoses, and pigmentation disorders. In addition, cosmetically pleasant sunscreens allow a sufficient amount to be applied and re-applied by consumers, ensuring continuous and even coverage of the exposed skin.

Objective: To evaluate the healing effects of an epidermal recovery gel in black-skin patients after small surgery with stitches.

Background: In treating atopic dermatitis (AD), a daily skin care routine is helpful to prevent flares and improve the quality of life. Investigate if the use of a stick in addition to an emollient balm is useful for atopic patients.

Introduction: Melasma is an acquired hyperpigmentation on sun-exposed areas. Multiple approaches are used to prevent and treat it, all including broad ultraviolet (UV) spectrum sunscreens. Short visible light can increase pigmentation on darker-skinned patients. The objective of the study was to assess the efficacy of a sunscreen with very high UVB and UVA protection that contains titanium dioxide and iron oxide pigments against visible light.

Background: Basal cell carcinoma (BCC) is the most common human skin cancer. The risk to develop BCC is strongly modified by environmental factors. It is positively associated with exposure to ultraviolet radiation, but negatively with exposure to tobacco smoke, whereas nothing is known about the role of air pollution.

Background: Atopic dermatitis (AD) is a recurrent disease needing daily use of an emollient to improve skin barrier and hydration. The objective of this study was to evaluate the efficacy of a lotion to improve lesions and therefore quality of life of atopic patients.

We developed an artificial intelligence algorithm (AIA) for smartphones to determine the severity of facial acne using the GEA scale and to identify different types of acne lesion (comedonal, inflammatory) and postinflammatory hyperpigmentation (PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles) obtained with smartphones (IOS and/or Android) from 1072 acne patients were collected. Three trained dermatologists assessed the acne severity for each patient. One acne severity grade per patient (grade given by the majority of the three dermatologists from the two sets of three images) was used to train the algorithm. Acne lesion identification was performed from a subgroup of 348 images using a tagging tool; tagged images served to train the algorithm. The algorithm evolved and was adjusted for sensibility, specificity and correlation using new images. The correlation between the GEA grade and the quantification and qualification of acne lesions both by the AIA and the experts for each image were evaluated for all AIA versions. At final version 6, the GEA grading provided by AIA reached 68% and was similar to that provided by the dermatologists. Between version 4 and version 6, AIA improved precision results multiplied by 1.5 for inflammatory lesions, 2.5 for non-inflammatory lesions and by 2 for PIHP; recall was improved by 2.6, 1.6 and 2.7. The weighted average of precision and recall or F1 score was 84% for inflammatory lesions, 61% for non-inflammatory lesions and 72% for PIHP.

The pigment responses of human skin to broadband UVA radiation (320-400 nm) occur in three distinct phases. The first phase includes immediate pigment darkening (IPD), the pigment that appears immediately after irradiation. The second phase involves an intermediate step, termed persistent pigment darkening (PPD), which leads to the third phase of neomelanogenesis or delayed tanning (DT). Since DT results from synthesis of new melanin, it persists beyond 5-7 days. We conducted studies on human subjects to investigate the dynamic responses of the IPD and PPD reactions to broadband UVA radiation at threshold and superthreshold doses. The threshold doses for IPD, PPD, and DT were found to be approximately 1, 11, and 18 J/cm(2), respectively. The colorimetry Delta L* value corresponding to minimal clinically perceptible pigmentation was found to be 0.8 +/- 0.1. IPD appeared immediately and had an associated decay constant of approximately 1.4 minutes. At doses greater than PPD threshold, IPD reaction decayed while PPD developed indicating toward IPD being used as a substrate in the formation of PPD.

Purpose: As many as 50% of patients with cancer develop acute skin reactions to some degree with radiotherapy. Proactive skin care is often recommended to minimise these skin reactions and maintain the integrity of the epidermal barrier; nevertheless, no consensual guidelines are systematically used. This multicentre, observational, prospective study evaluated the tolerability and benefit of supportive and barrier protective skin care products in preventing radiotherapy-induced skin reactions in 253 women initiating radiotherapy (exclusive or adjuvant) for breast cancer. Methods: Patients received a kit of 5 commercially available skin care products before the first radiotherapy treatment. The following variables were assessed: cutaneous adverse events, investigator-assessed skin reactions (oedema, erythema, dryness, desquamation) before and after radiotherapy course, investigator, and patient opinion on products benefit. Results were analysed by frequency of product use (heavy versus low). Results: Average age was 60 years (range: 34-85). Over 92% of patients reported good to excellent tolerance on irradiated skin for each product. During the 6-week radiotherapy period, we observed that heavy product users had less skin reactions than the low users, particularly within 10 days of radiotherapy initiation (8% versus 18%; p = .031). Positive physician’s opinion on product use was more frequent for high (66.6%) versus low (32%) users. Patient-assessed patient benefit index was generally >1, indicating relevant treatment benefit, with a tendency for better benefit in high versus low users. Conclusions: These results support recommendations to use skin care products to minimise the impact of secondary cutaneous reactions with radiotherapy cancer treatment.

Introduction The purpose of this multicenter, prospective, observational, open-label study was to evaluate the use and tolerability of dermo-cosmetic products in preventing skin reactions associated with cancer treatments. Patients and methods A 12-product kit was supplied to patients before chemotherapy began and was to be used throughout the treatment phase. Cutaneous adverse events were evaluated at each treatment session. Physicians evaluated skin reactions (edema, erythema, dryness, desquamation, pigmentation disorders, and cracks) and gave their opinion on the skin benefit for patients at the end of the study. Patients also evaluated the product benefit using the Patient Benefit Index (PBI) questionnaire. Results were analyzed by subgroups of casual and regular users, based on number and frequency of products used. Results A total of 147 patients were enrolled in cancer services in Germany, France, Italy, Spain, and Canada. Mean age was 59 years with 71% being female. Product tolerance on whole body was rated good to excellent for at least 89% of the patients for each product. Aggravated skin reactions during the study were reported more frequently by casual users than regular users (39.5% versus 22%; p=0.029). Similarly, casual users reported more erythema aggravation (p=0.02) and desquamation (p=0.03) than regular users. PBI >1 was reported for 95.5% of patients and regular users had significantly higher scores than casual users (p=0.049). Discussion Overall, the 12-product kit was very well tolerated, with regular users reporting benefits more frequently than casual users. Results support international recommendations to use appropriate skin care products to minimize the impact of cutaneous reactions associated with chemotherapy.

Excessive ultraviolet (UV) radiation induces acute and chronic effects on the skin, eye and immune system. Personalized monitoring of UV radiation is thus paramount to measure the extent of personal sun exposure, which could vary with environment, lifestyle, and sunscreen use. Here, we demonstrate an ultralow modulus, stretchable, skin-mounted UV patch that measures personal UV doses. The patch contains functional layers of ultrathin stretchable electronics and a photosensitive patterned dye that reacts to UV radiation. Color changes in the photosensitive dyes correspond to UV radiation intensity and are analyzed with a smartphone camera. A software application has feature recognition, lighting condition correction, and quantification algorithms that detect and quantify changes in color. These color changes are then correlated with corresponding shifts in UV dose, and compared to existing UV dose risk levels. The soft mechanics of the UV patch allow for multi-day wear in the presence of sunscreen and water. Two evaluation studies serve to demonstrate the utility of the UV patch during daily activities with and without sunscreen application.

BACKGROUND/AIMS:There is increasing evidence that exposure to air pollutants, including particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. We assessed the association between ambient air pollutant concentrations and the number of visits of patients for acne vulgaris to a dermatological outpatient clinic in Beijing, China, from April 1, 2012 to April 30, 2014.METHODS:In this time period, 59,325 outpatient visits were recorded because of acne vulgaris. Daily air pollution parameters for PM10, PM2.5, SO2, and NO2 were obtained from the Beijing Municipal Environmental Monitoring Center.RESULTS:Increased concentrations of ambient PM2.5, PM10, and NO2 were significantly associated with increased numbers of outpatient visits for acne vulgaris over the 2 years. These effects could be observed for NO2 in a single-pollutant model and for PM2.5, PM10, and NO2 in 2-pollutant models, which are closer to real-life exposure. Of note, these effects were specific because they were not observed for increased SO2 concentrations, which even showed negative correlations in all test models.CONCLUSION:This study provides indirect evidence for a link between acne vulgaris and air pollution.

In recent years, the critical role that inflammation may play in the development and progression of acne has become increasingly recognized. The prevalence of acne is similar between Asian and Caucasian women, but Asian women have a higher prevalence of inflammatory acne. They also report their symptoms exacerbate during periods of high air pollution. The objective of this study was to review the current evidence that links air pollution to worsening of acne symptoms. Firstly, a group of five Asian and three European scientists with expertise in Dermatology reviewed the current literature and described current acne treatment practices in their countries. During this activity, they identified the need for further epidemiological and clinical research. Secondly, additional studies ensued which provided evidence that acne symptoms might exacerbate in regions of high ambient air pollution. Based on these findings, the authors suggest that people with acne should protect the natural barrier function of their skin with emollients and ultraviolet (UV)A/UVB protection.

during 14 days showed a significant reduction of their SCORAD and Local SCORAD associated with an increase of their bacterial diversity (Shannon Index) and a reduction of Staphylococci level (both S. epidermis and S. aureus). These results indicated that this syndet is useful for patients suffering from atopic dermatitis and can reduce the skin microbiota dysbiosis associated with this pathology. However, use of an adapted emollient (supplemented with the same biomass (1)) in addition to syndet is important for atopic patient’s management. S. SEITE, D. MOYAL La Roche-Posay Dermatological Laboratories, Asnières, France OBJECTIVE