A new, rapid and selective, HPLC method for simultaneous quantitative estimation of lisinopril and hydrochlorothiazide residues and sampling procedures from pharmaceutical manufacturing equipment surfaces were developed and validated. The sampling procedures have a good recovery (>80%). The limit of quantitation of the HPLC method 0.155 μg/mL and 0.025 μg/mL for lisinopril and hydrochlorothiazide, respectively.