The determination of the new antidepressant drug sertraline and its main metabolite, desmethylsertraline, in human serum is described. A new solid-phase extraction method employing the dual functionality Clean Screen® cartridge is presented followed by reversed-phase liquid chromatographic (LC) analysis. The sample preparation yielded extremely clean extracts and absolute recoveries in excess of 90% for both drugs from human serum. The response of the LC system was linear over the concentration range 0.01–2.5 mg/l for both sertraline and desmethylsertraline with a limit of detection of 0.01 mg/l. A gas chromatographic—mass spectrometric (GC—MS) system is also described should confirmation of the drugs be necessary.
John Newhook合作论文数1
Christine Moore合作论文数1Baidar Bakht合作论文数1G. Tadros合作论文数1
Nemkumar Banthia合作论文数Department of Civil Engineering, Faculty of Applied Science, The University of British Columbia1
Brahim Benmokrane合作论文数Department of Civil & Building Engineering, University of Sherbrooke1Melissa C Marr合作论文数1David Lai合作论文数1Ruth Eden合作论文数1
Björn Täljsten合作论文数Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology1Marie-Anne Erki合作论文数1
Vistasp Karbhari合作论文数Department of Mechanical and Aerospace Engineering, The University of Texas at Arlington;Department of Civil Engineering, The University of Texas at Arlington1Kenneth Neale合作论文数1Jadwiga Kroman合作论文数1Shamim Sheikh合作论文数1Isabelle Leclerc合作论文数1Atsuhiko Machida合作论文数1G Long合作论文数1
Aftab Mufti合作论文数University of Manitoba1Gérard Desgagné合作论文数1
