We report the discovery of a novel series of spiroindoline-based inhibitors of Sky kinase that bind in the ATP-binding site and exhibit high levels of kinome selectivity through filling the Ala571-subpocket. These inhibitors exhibit moderate oral bioavailability in the rat due to low absorption across the gut wall.

AbstractThe title cyclization reactions provide bicyclic compounds such as (II) or (IV).

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic applications of Group V metallacyclopropenes. Part 1. Group V metallacyclopropenes in synthesis. An efficient route to polyfunctional ring systems via the cocyclization of diynes with substituted monoacetylenesAndrew C. Williams, Pamela Sheffels, Derek Sheehan, and Tom LivinghouseCite this: Organometallics 1989, 8, 6, 1566–1567Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/om00108a034https://doi.org/10.1021/om00108a034research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

ChemInformVolume 20, Issue 40 Preparative Organic Chemistry ChemInform Abstract: Group V Metallacyclopropenes in Synthesis. An Efficient Route to Polyfunctional Ring Systems via the Cocyclization of Diynes with Substituted Monoacetylenes. A. C. WILLIAMS, A. C. WILLIAMS Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorP. SHEFFELS, P. SHEFFELS Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorD. SHEEHAN, D. SHEEHAN Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorT. LIVINGHOUSE, T. LIVINGHOUSE Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this author A. C. WILLIAMS, A. C. WILLIAMS Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorP. SHEFFELS, P. SHEFFELS Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorD. SHEEHAN, D. SHEEHAN Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this authorT. LIVINGHOUSE, T. LIVINGHOUSE Dep. Chem., Mont. State Univ., Bozeman, MT 59717, USASearch for more papers by this author First published: October 3, 1989 https://doi.org/10.1002/chin.198940097AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue40October 3, 1989 RelatedInformation