The blood pool agent indo-cyanine green (ICG) has been investigated in a prospective clinical study for detection of rheumatoid arthritis using fluorescence imaging. Temporal behavior as well as spatial distribution of fluorescence intensity are suited to differentiate healthy and inflamed finger joints after i.v. injection of an ICG bolus.

The dye ICG was investigated in a clinical study for evaluation of rheumatoid arthritis using fluorescence imaging. Second moments of correlated time series of fluorescence intensities were analysed to differentiate healthy subjects from diseased.