Background The purpose of this study was to determine whether the proportion of metastatic cervical lymph nodes resected (metastatic lymph node ratio [MLNR]) predicted papillary thyroid carcinoma (PTC) recurrence, and whether MLNR could alter the predictive ability of TNM nodal classification for recurrence in PTC. Methods We conducted a retrospective review of patients with PTC who underwent a total or near-total thyroidectomy with at least 1 lymph node removed at our institution. Results Of 253 patients, 35 (13.8%) developed recurrent disease. The total MLNR (ratio between total metastatic lymph nodes and total number of lymph nodes resected) independently predicted PTC recurrence (odds ratio [OR], 1.024; 95% confidence interval [CI], 1.0101.039; p = .001). In receiver operating characteristic (ROC) curve analysis, TNM nodal classification with total MLNR had greater accuracy in predicting PTC recurrence than did TNM nodal classification alone (0.726 and 0.675, respectively). Conclusion MLNR is an independent predictor of PTC recurrence and enhances the predictive value of TNM nodal classification. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013

ThyroidVol. 22, No. 7 Letter to the EditorStimulated Thyroglobulin and Neck Ultrasonography Facilitates Postsurgical Radioactive Iodine Remnant Ablation Selection in Patients with Low-Risk Well-Differentiated Thyroid CarcinomaKaren Gomez Hernandez, Daniel Etarsky, Steven Orlov, and Paul G. WalfishKaren Gomez HernandezEndocrine Division, Department of Medicine, Mount Sinai Hospital and University of Toronto Medical School, Toronto, Canada.Search for more papers by this author, Daniel EtarskyEndocrine Division, Department of Medicine, Mount Sinai Hospital and University of Toronto Medical School, Toronto, Canada.Search for more papers by this author, Steven OrlovEndocrine Division, Department of Medicine, Mount Sinai Hospital and University of Toronto Medical School, Toronto, Canada.Search for more papers by this author, and Paul G. WalfishEndocrine Division, Department of Medicine, Mount Sinai Hospital and University of Toronto Medical School, Toronto, Canada.Department of Otolaryngology, Head and Neck Surgery, Joseph & Mildred Sonshine Family Centre for Head & Neck Diseases, Mount Sinai Hospital and University of Toronto Medical School, Toronto, Canada.Search for more papers by this authorPublished Online:29 Jun 2012https://doi.org/10.1089/thy.2011.0453AboutSectionsView articleView Full TextPDF/EPUB ToolsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View article"Stimulated Thyroglobulin and Neck Ultrasonography Facilitates Postsurgical Radioactive Iodine Remnant Ablation Selection in Patients with Low-Risk Well-Differentiated Thyroid Carcinoma." , 22(7), pp. 760–761FiguresReferencesRelatedDetailsCited ByPost-operative stimulated thyroglobulin and neck ultrasound as personalized criteria for risk stratification and radioactive iodine selection in low- and intermediate-risk papillary thyroid cancer20 March 2015 | Endocrine, Vol. 50, No. 1Lessons learned from thyroglobulin concentrations after total thyroidectomy and radioactive iodine ablation for differentiated thyroid cancerClinical Biochemistry, Vol. 48, No. 12Post-operative neck ultrasound and risk stratification in differentiated thyroid cancer patients with initial lymph node involvementEuropean Journal of Endocrinology, Vol. 170, No. 6 Volume 22Issue 7Jul 2012 InformationCopyright 2012, Mary Ann Liebert, Inc.To cite this article:Karen Gomez Hernandez, Daniel Etarsky, Steven Orlov, and Paul G. Walfish.Stimulated Thyroglobulin and Neck Ultrasonography Facilitates Postsurgical Radioactive Iodine Remnant Ablation Selection in Patients with Low-Risk Well-Differentiated Thyroid Carcinoma.Thyroid.Jul 2012.760-761.http://doi.org/10.1089/thy.2011.0453Published in Volume: 22 Issue 7: June 29, 2012Online Ahead of Print:June 4, 2012PDF download