In 2020, the COVID-19 pandemic impacted global life and transitioned economies and societal perceptions of life as we knew it. Professional and social life mostly ground to a nadir during the first lockdown in Europe in March. As a consequence, measures aimed at preventing the spread of the virus were established in medical facilities also and elective plastic surgery procedures were temporarily suspended in our clinic and others. A majority of the population, including those potentially contemplating plastic surgery procedures, spent most of their time at home with ample time available to research information about surgical procedures and other topics online. This investigation analyzes the relevance of plastic surgery during the pandemic on the basis of online search behavior patterns. Online traffic data from the online platform http://www.mooci.org were extracted using Google Analytics over a period of 6 months. The parameters analyzed were: pageviews, session duration, and bounce rate. Additionally, differentiation by areas of interest has been obtained. The data were compared and analyzed before and after the beginning of the first hard lockdown in Austria, Germany, and Switzerland. There were no significant differences in regard to pageviews and session duration when comparing time points before and after the beginning of the hard lockdown. The bounce rate exhibited a significant decrease after the beginning of the lockdown, implying a more conscious search for information and greater absorption and retention. There was no difference that could conclusively be attributed to the pandemic in terms of specific areas of interest researched. Society’s demand for information about plastic-surgical procedures continues to be steadily prevalent—despite, or even in particular, during a global pandemic. Providing reliable and readily available information about plastic surgery procedures is an important component of a functioning doctor–patient relationship and informed consent. This information may reflect society’s increased interest in plastic surgery during the pandemic, or be simply reflective of more spare time at hand to allow for such research. Further studies should investigate the relevance of elective procedures over the entire course of the pandemic.

Background As the cost of healthcare rises, it is imperative to assess value delivered to patients and impact on the economic viability of institutions. We aimed to characterize plastic surgery operative time management and identified areas for efficiency improvement. Methods Procedures from a US academic plastic surgery division from September 2017 to August 2018 were reviewed. Times were categorized into preparation (patient in room to incision), procedure (incision to closure), exit (closure to patient exiting room), and turnover (patient out of room to next patient in room). Median and interquartile ranges were calculated. Procedures were classified by relative value units (RVUs) for comparison of procedure complexities and resources. Components were plotted against RVUs; r2 values were calculated. Results We analyzed 522 cases; 69 were excluded for missing data, primary surgeon not a plastic surgeon, emergent cases, or burn procedures; a total of 453 cases were analyzed. Median and interquartile range (in minutes) for preparation was (34, 18 minutes; 23% of total), procedure (53, 75 minutes; 36% of total), exit (30, 27 minutes; 20% of total), and turnover (30, 26 minutes; 20% of total). Normalized to RVUs, preparation demonstrated the most variability (r2 = 0.19), followed by exit (r2 = 0.38), and procedure (r2 = 0.57). Average work RVUs per month was 678.1 ± 158.7. Average work RVUs per OR hour was 7.2. Conclusions The largest component with greatest variability was preparation for surgery in the OR. Improved efficiency by decreasing variability increases the value of healthcare delivered to patients and OR throughput.

Chronic wounds are a challenging medical entity for patients, medical professionals and healthcare systems. Frequently, patients present themselves to wound specialists after months or even years of unsuccessful treatment. Recent developments have resulted in a multitude of different advanced wound dressings created to treat complex, chronic wounds, one of which is the polylactide dressing Suprathel. This study aimed at investigating the healing potential of Suprathel in chronic wounds and differentiating between old and "young", diabetic and non-diabetic chronic wounds. A prospective, multicentric, non-controlled intervention study was conducted, treating patients with chronic lower leg ulcers (>3 months) with Suprathel and assessing them weekly. Afterwards, a retrospective analysis was performed analysing the wound size initially, after 4 and after 8 weeks of treatment. Furthermore, a differentiation between diabetic and non-diabetic, and chronic wounds older and younger than 12 months, was assessed. A significant reduction in wound size was observed in the study population after 8 weeks of treatment. The effect size in the diabetic wound and the old chronic wound group even reached more than one, with the other groups still showing a large effect of the intervention. This study shows that Suprathel is a valuable tool in the armamentarium of a wound specialist. Not only could we show a positive effect on chronic wounds, we could even demonstrate a significant wound size reduction in chronic wounds of old and young, as well as diabetic wounds, with the treatment of older chronic and diabetic wounds yielding an even larger effect size. Further randomised, controlled studies are necessary to show the full potential of advanced wound dressing materials in large patient cohorts.

Background: For the treatment of carpometacarpal arthritis of the thumb, various therapies are used. Infiltration therapy with autologous substances such as platelet-rich plasma and autologous fat have recently gained increasing attention because of beneficial pain-reducing effects in arthritis and the associated regenerative potential. However, the extent of clinical evidence in this area and how well autologous substances work in terms of pain reduction and improvements in hand function remain unclear. Methods: A systematic review and meta-analysis were conducted to evaluate the current evidence and to provide more insight into pain reduction and improvement in hand function after infiltration of autologous substances. The authors identified 11 clinical trials, of which we included eight in the meta-analysis. Results: Autologous substances achieved a good and long-lasting pain reduction, which may also be accompanied by corresponding improvement in hand function. Autologous substances appear to be more effective than corticoid infiltrations. The infiltration of autologous fat seems to be particularly promising in more advanced stages of carpometacarpal arthritis of the thumb. Our meta-analysis showed a mean pain reduction of 2.4 to 3 in visual analogue scale score and a reduction of 18 to 19 points in the Disabilities of the Arm, Shoulder, and Hand questionnaire after infiltration with autologous substances. Conclusion: Both platelet-rich plasma and autologous fat infiltration offer an efficient and long-lasting, minimally invasive therapy option in the treatment of carpometacarpal arthritis of the thumb.

Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.

Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.

Background: Zosyn® (piperacillin-tazobactam; Pfizer Medical, New York, NY), a valuable antibiotic against gram-negative bacteria, combined with vancomycin (Z+V) is known for its high incidence of acute kidney injury (AKI), particularly in the intensive care unit (ICU), leading to the frequent use of alternatives for gram-negative coverage (Alt+V). Because there are limited data describing AKI on these alternative antibiotic agents, a systematic review and meta-analysis was conducted to determine if these regimens were indeed associated with decreased rates of AKI. Patients and Methods: A literature review was performed electronically from its inception to November 1, 2018, screening for relevant literature by title, abstract and full text according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines within the following databases: PubMed/Medline, CINAHL, Scopus, and Cochrane Central Register of Controlled Trials. Studies were included if they contained adults who had been admitted to the ICU for treatment and had received a combination of intravenous Z + V or Alt+V as well as had AKI measured during administration of these antibiotic agents. Studies were excluded if they represented pediatric populations, did not receive care in an ICU during their hospital admission, only received monotherapy for antibiotic treatment or received antibiotic treatment for less than 48 hours. Independent extraction was performed by two reviewers. Risk of bias was assessed using the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) methodology for retrospective studies. Random-effects models were used to calculate any differences between rates of AKI after Z + V or Alt + V. Results: Fourteen articles (totaling 30,399 patients) were included. All studies available were retrospective in design. Compared with Alt + V, Z + V was associated with a higher risk ratio of AKI (1.79; 95% confidence interval [CI], 1.46-2.19; p < 0.001). Cefepime (C + V) was the most common alternative to Zosyn, and Z + V was associated with higher rates of kidney injury compared with C + V (1.70; 95% CI, 1.36-2.12; p < 0.00001). However, there was substantial heterogeneity in the data collected as well as high risk of bias. Conclusions: Zosyn plus vancomycin is associated with more risk of AKI compared with Alt+V coverage in ICU adult populations. However, the conclusions were limited by the retrospective nature of the studies, high bias of included articles, and heterogeneity of the included studies.

Basal cell carcinoma (BCC) is the most common skin cancer worldwide, and its incidence is increasing due to the aging population and the cumulative effects of widespread sun exposure. The Wnt gene family is involved in cell growth regulation, differentiation, and organogenesis, and not surprisingly, Wnt genes have been linked to oncogenesis. Specifically, β-catenin, a key signaling regulator of the Wnt pathway, is involved in the genesis of numerous human cancers including BCCs. Dysregulation of the patched/hedgehog intracellular signaling pathway, other important pathways regulating cell growth and regulation, has also been linked to BCCs. In this review, we outline the key mechanisms of the Wnt and patched/hedgehog intracellular signaling pathways and their involvement in the development, homeostasis, and progression of BCCs. Level of Evidence: Not gradable.

Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds. This article describes the demands of the product and the steps that were taken to meet these requirements. The material choice was based on the degradation and full resorption of polylactides to lactic acid and its salts. The structure and morphology of the physical, biological, and degradation properties were selected to increase the angiogenetic abilities, fibroblasts, and extracellular matrix generation. Water vapor permeability and plasticity were adapted for clinical use. The available scientific literature was screened for the use of this product. A clinical application demonstrated pain relief paired with a reduced workload, fast wound healing with a low infection rate, and good cosmetic results. A better understanding of the product's degradation process explained the reduction in systemic oxidative stress shown in clinical investigations compared to other dressings, positively affecting wound healing time and reducing the total area requiring skin grafts. Today, the product is in clinical use in 37 countries. This article describes its development, the indications for product growth over time, and the scientific foundation of treatments.

Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metalloproteinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized “bio-reactor,” disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and proliferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound’s pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wounds. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Zusammenfassung Einleitung Im Frühjahr 2020 machte die COVID-19-Pandemie weitreichende Veränderungen und Maßnahmen in bisher nie dagewesenem Ausmaß notwendig. Diese Maßnahmen zielten einerseits darauf ab die Ausbreitung der Virusinfektion einzudämmen, und andererseits die landesweite Krankenversorgung weiterhin zu gewährleisten, insbesondere um im Falle einer größeren Anzahl an mit COVID-19 infizierten Patienten ausreichend Intensivkapazitäten zur Verfügung zu haben. In Bezug auf operative Fächer bedeutete dies das temporäre Aussetzen des Elektivprogramms auf unbestimmte Zeit. Ziel dieser Studie war es die Auswirkung dieser Maßnahmen auf das Behandlungsspektrum eines plastisch-chirurgischen Zentrums zu evaluieren. Methode Die Operationszahlen der klinischen Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie der medizinischen Universität Graz während des sog. Lockdowns von 16.3.2020 bis 26.4.2020 (6 Wochen) sowie 2 Wochen davor wurden retrospektiv erhoben. Die Daten wurden zum korrespondierende Vorjahreszeitraum verglichen. Untersucht wurden u. a. Operationsspektrum, Dringlichkeit, Indikation und Komplikationsraten. Ergebnisse Durch den Wegfall des Elektivprogramms kam es während des Lockdowns im Jahresvergleich zu einem signifikanten Rückgang der OP-Zahlen um 57,5 % (2019: 353, 2020 150 Fälle). Während des Lockdowns wurden im Jahresvergleich signifikant mehr Notfall- und Akuteingriffe durchgeführt (2019: 41, 2020: 58 Fälle, p < 0,001). Außerdem wurde eine signifikante Häufung von Selbstverletzungen bzw. Suizidversuchen beobachtet (2019: 0, 2020: 16 Fälle, p > 0,001). Hinsichtlich Privat- und Arbeitsunfällen gab es keine signifikanten Unterschiede. Es zeigte sich auch kein signifikanter Unterschied bezüglich der Komplikationsrate (2019: 6,8, 2020: 10 %, p = 0,219). Zusammenfassung Ein signifikanter Anteil plastisch-chirurgischer Operationen an einem Universitätsklinikum mit überregionalem Versorgungsauftrag besteht aus Notfalloperationen, akuten und dringenden medizinisch notwendigen Operationen. Während des Lockdowns wurden Operationen ohne signifikanten Anstieg der Komplikationsrate durchgeführt. Trotz sämtlicher Herausforderungen während der Pandemie konnte eine qualitativ konstante Patientenversorgung auf höchstem Niveau gewährleistet werden. Um die während des Lockdowns angehäuften weniger dringenden, jedoch ebenso wichtigen Fälle zeitgerecht und in entsprechend hoher Qualität abzuarbeiten, wird eine Erweiterung der Operationskapazitäten mit Steigerung der Bettenanzahl und der Ambulanzkapazität notwendig sein. Die vorliegenden Ergebnisse zeigen, wie wichtig die Plastische Chirurgie für die medizinische Versorgung insbesondere in Krisenzeiten ist.

Background: Fungal burn wound infections are among the most devastating complications in patients who are severely burned. Increasing incidence of burn wound infections caused by fungi led to new challenges in diagnostic and therapeutic approaches. The wide use of broad-spectrum antibiotic agents, an increased prevalence of molds and non-Candida albicans spp., and the variety of available antifungal agents underline the importance of identifying the causative species, to initiate adequate therapy within an adequate timeframe. Methods: Review of the pertinent English and German literature. Results: Fungal burn wound infections go along with a delay of identifying the causative fungus species and can be mistaken for early bacterial burn wound infection. Recently, an increase of uncommon fungal pathogens and fungi resistance against antifungal agents has been reported. Amphotericin B and voriconazole remain the antifungal drugs used most commonly. Conclusions: Adequate therapy remains challenging. Early radical debridement and wound closure play an imperative part, particularly in preventing infections caused by yeasts and molds or any other agent. Prophylactic empiric pharmacologic treatment is reserved for those highly at risk for invasive burn wound infection only. Because of the emergence of drug-resistant fungi, the development of new antifungal drugs is essential for the battle against fungal burn wound infections.

Purpose: Burn care is a highly relevant medical specialty in every part of the world. Different infrastructure, healthcare systems and access to medical supplies lead to different needs, treatment strategies and outcomes. A fundamental tool in a burn care provider's armamentarium is the use of different dressings. Several studies have investigated the question of the ideal burn dressing, but none could achieve a proper global perspective. With advanced dressings being on the rise, we conducted this study to get a global understanding of the actual use and idea of the ideal burn dressing. Objective: The objective of this study was to investigate the understanding of an 'ideal burn dressing' on a global scale. Materials and methods: A questionnaire about burn care and the ideal burn dressing has been created and translated to five of the most spoken languages world-wide (English, Spanish, French, Chinese, Indonesian). It has been uploaded to an online survey platform and sent out to burn experts worldwide. The voluntary participation was possible for a period of four weeks. Results: In total, 196 respondents from 49 countries participated in the study, yielding a response rate of 24.5%. The most important burn dressing characteristics in a cumulative ranking were (1) lack of adhesion (80.54%), (2) pain-free dressing change (79.87%), (3) requirement of fewer dressing changes, while in a linear ranking they were (1) anti-infective (35.14% 1st), pain-reduction (24.14% 2nd), and high absorbency (23.49% 3rd). Silver-based dressings are the most used dressings for superficial (45.21%) and deep (52.78%). 94.81% believe that the choice of burn dressing affects the outcome.

Zusammenfassung Einleitung Im Fruhjahr 2020 machte die COVID-19-Pandemie weitreichende Veranderungen und Ma ss nahmen in bisher nie dagewesenem Ausma ss notwendig. Diese Ma ss nahmen zielten einerseits darauf ab die Ausbreitung der Virusinfektion einzudammen, und andererseits die landesweite Krankenversorgung weiterhin zu gewahrleisten, insbesondere um im Falle einer gro ss eren Anzahl an mit COVID-19 infizierten Patienten ausreichend Intensivkapazitaten zur Verfugung zu haben. In Bezug auf operative Facher bedeutete dies das temporare Aussetzen des Elektivprogramms auf unbestimmte Zeit. Ziel dieser Studie war es die Auswirkung dieser Ma ss nahmen auf das Behandlungsspektrum eines plastisch-chirurgischen Zentrums zu evaluieren. Methode Die Operationszahlen der klinischen Abteilung fur Plastische, Asthetische und Rekonstruktive Chirurgie der medizinischen Universitat Graz wahrend des sog. Lockdowns von 16.3.2020 bis 26.4.2020 (6Wochen) sowie 2Wochen davor wurden retrospektiv erhoben. Die Daten wurden zum korrespondierende Vorjahreszeitraum verglichen. Untersucht wurden u.a. Operationsspektrum, Dringlichkeit, Indikation und Komplikationsraten. Ergebnisse Durch den Wegfall des Elektivprogramms kam es wahrend des Lockdowns im Jahresvergleich zu einem signifikanten Ruckgang der OP-Zahlen um 57,5% (2019: 353, 2020150Falle). Wahrend des Lockdowns wurden im Jahresvergleich signifikant mehr Notfall- und Akuteingriffe durchgefuhrt (2019: 41, 2020: 58Falle, p<0,001). Auerdem wurde eine signifikante Haufung von Selbstverletzungen bzw. Suizidversuchen beobachtet (2019: 0, 2020: 16Falle, p>0,001). Hinsichtlich Privat- und Arbeitsunfallen gab es keine signifikanten Unterschiede. Es zeigte sich auch kein signifikanter Unterschied bezuglich der Komplikationsrate (2019: 6,8, 2020: 10%, p=0,219). Zusammenfassung Ein signifikanter Anteil plastisch-chirurgischer Operationen an einem Universitatsklinikum mit uberregionalem Versorgungsauftrag besteht aus Notfalloperationen, akuten und dringenden medizinisch notwendigen Operationen. Wahrend des Lockdowns wurden Operationen ohne signifikanten Anstieg der Komplikationsrate durchgefuhrt. Trotz samtlicher Herausforderungen wahrend der Pandemie konnte eine qualitativ konstante Patientenversorgung auf hochstem Niveau gewahrleistet werden. Um die wahrend des Lockdowns angehauften weniger dringenden, jedoch ebenso wichtigen Falle zeitgerecht und in entsprechend hoher Qualitat abzuarbeiten, wird eine Erweiterung der Operationskapazitaten mit Steigerung der Bettenanzahl und der Ambulanzkapazitat notwendig sein. Die vorliegenden Ergebnisse zeigen, wie wichtig die Plastische Chirurgie fur die medizinische Versorgung insbesondere in Krisenzeiten ist. Abstract Introduction In spring 2020, the COVID-19 pandemic required far-reaching changes and measures of unprecedented extent. These measures were implemented to reduce virus spread and to ensure the continuity of nation-wide medical care, in particular with a view to having sufficient intensive-care capacities in case of a large caseload of patients infected with COVID-19. With regard to surgical specialties, this implied a temporary hold on elective cases for an indefinite period of time. The aim of this study was to assess the impact of these measures on the caseload of a level-three plastic surgery unit. Methods This study retrospectively assessed the caseload at the Division of Plastic, Aesthetic and Reconstructive Surgery at Medical University Graz during the so-called lockdown from 16March 2020 to 27April 2020 (6weeks) as well as two weeks before. The data was compared with the corresponding time period of the year 2019.Surgical spectrum, procedural urgency, medical indication of surgical procedures as well as complication rates were compared. Results The suspension of elective cases led to a significant reduction in caseload of 57.5% (2019: 353, 2020: 150 cases). There was a significant increase in emergency and acute case procedures performed during the lockdown compared with the previous year (2019: 41, 2020: 58 cases, p<0.001). Furthermore, the number of self-inflicted injuries and suicide attempts increased significantly (2019: 0, 2020: 16 cases, p<0.001). With regard to private and work-related injuries, there was no significant difference. Also, there was no difference in complication rates (2019: 6.8, 2020: 10%, p=0.219). Conclusion A significant amount of surgical procedures in plastic surgery at a supraregional academic health centre consists of emergency, acute and urgent medically necessary cases. During the lockdown, surgical procedures were performed without a significant increase in complication rates. Despite challenges during the pandemic, high-quality patient care was provided throughout. To process less urgent yet important cases accumulated during the lockdown in a reasonable amount of time and maintaining the same level of high-quality care, additional capacities regarding operating rooms, hospital beds and outpatient care are needed. These results point out the importance of plastic surgery for medical care, in particular during times of crisis.

Background and Objectives: Porcine xenografts have been used successfully in partial thickness burn treatment for many years. Their disappearance from the market led to the search for effective and efficient alternatives. In this article, we examine the synthetic epidermal skin substitute Suprathel® as a substitute in the treatment of partial thickness burns. Materials and Methods: A systematic review following the PRISMA guidelines has been performed. Sixteen Suprathel® and 12 porcine xenograft studies could be included. Advantages and disadvantages between the treatments and the studies’ primary endpoints have been investigated qualitatively and quantitatively. Results: Although Suprathel had a nearly six times larger TBSA in their studies (p < 0.001), it showed a significantly lower necessity for skin grafts (p < 0.001), and we found a significantly lower infection rate (p < 0.001) than in Porcine Xenografts. Nonetheless, no significant differences in the healing time (p = 0.67) and the number of dressing changes until complete wound healing (p = 0.139) could be found. Both products reduced pain to various degrees with the impression of a better performance of Suprathel® on a qualitative level. Porcine xenograft was not recommended for donor sites or coverage of sheet-transplanted keratinocytes, while Suprathel® was used successfully in both indications. Conclusion: The investigated parameters indicate that Suprathel® to be an effective replacement for porcine xenografts with even lower subsequent treatment rates. Suprathel® appears to be usable in an extended range of indications compared to porcine xenograft. Data heterogeneity limited conclusions from the results.

ABSTRACT Patients who experience severe burn injuries face a massive inflammatory response resulting in hemodynamic and cardiovascular complications. Even after immediate and appropriate resuscitation, removal of burn eschar and covering of open areas, burn patients remain at high risk for serious morbidity and mortality. As a result of the massive fluid shifts following the initial injury, along with large volume fluid resuscitation, the cardiovascular system is critically affected. Further, increased inflammation, catecholamine surge, and hypermetabolic syndrome impact cardiac dysfunction, which worsens outcomes of burn patients. This review aimed to summarize the current knowledge about the effect of burns on the cardiovascular system. A comprehensive search of the PubMed and Embase databases and manual review of articles involving effects of burns on the cardiovascular system was conducted. Many burn units use multimodal monitors (e.g., transpulmonary thermodilution) to assess hemodynamics and optimize cardiovascular function. Echocardiography is often used for additional evaluations of hemodynamically unstable patients to assess systolic and diastolic function. Due to its noninvasive character, echocardiography can be repeated easily, which allows us to follow patients longitudinally. The use of anabolic and anticatabolic agents has been shown to be beneficial for short- and long-term outcomes of burn survivors. Administration of propranolol (non-selective β-receptor antagonist) or oxandrolone (synthetic testosterone) for up to 12 months post-burn counteracts hypermetabolism during hospital stay and improves cardiac function. A comprehensive understanding of how burns lead to cardiac dysfunction and new therapeutic options could contribute to better outcomes in this patient population.

Currently, patients seek healthcare information online. An up-to-date online presence is vital for success among the competition amid hospitals. Hospital websites have become an important medium to communicate with patients, provide information about certain diseases/conditions, and advertise healthcare services. This study aims to evaluate burn centers websites verified by the American Burn Association (ABA). The online presence of the 73 ABA-verified burn centers was evaluated according to criteria previously published by Benedikt et al. This included general information on burns, first aid, treatment at the burn unit, research, and education. ABA-verified burn centers were then compared with 48 German-speaking burn centers evaluated by Benedikt et al. Online information about patient care including treatment options and techniques was more often present in ABA-verified burn centers. However, this information was still provided in only half of the websites. Furthermore, ABA-verified burn centers more often used multimedia-based elements and social media platforms. On the other hand, German-speaking burn centers more often provided translations, general information (eg, staff and ward) about the burn center, as well as research and education. This study demonstrates that although many burn centers have well-designed websites, relevant burn-related information on patient care, research, and education is often missing or sparse. Today, most patients look for healthcare information online. Also, applicants for residency or fellowship programs tend to get a first picture of their potential employer on websites or social media. Keeping websites and social media up-to-date and informative can improve recruitment of patients and employees.