article: A case of lichenoid pigmented purpuric dermatitis of Gougerot-Blum after amoxicillin - Italian Journal of Dermatology and Venereology 2021 December;156(Suppl. 1 to No. 6):74-5 - Minerva Medica - Journals

We report the cases of two women affected by lichen sclerosus also having clinical signs of hidradenitis suppurativa. Lichen sclerosus is a chronic autoimmune disease, in which activated fibroblasts produce significantly altered collagen leading to fibrosis Hidradenitis suppurativa is a chronic relapsing inflammatory disease affecting folliculopilosebaceous unit and apocrine gland, which lesions are nodules and abscesses. The association between lichen sclerosus and autoimmune disorders is well known, but not the one with hidradenitis suppurativa. We present two case reports of these unusual comorbidities.

Background Hidradenitis suppurativa is an inflammatory skin disease that presents a recurrence of painful and suppurating lesions in the apocrine gland-bearing regions, with a strong impact on the patients' life quality. Despite its peculiar presentation, early forms are often underestimated by patients and this would inevitably result in late diagnosis and delayed therapy. Objectives Improved communication around the disease could facilitate self-diagnosis and a quicker response from healthcare practitioners, especially in this moment when we dispose of effective treatment against this disease. Methods A HS awareness campaign was conducted for 2 years with the help of a media agency and a patients' association. Results Results confirm that a better communication has a strong impact on the disease awareness. Conclusions This paper demonstrates that the more this disease awareness is carried on, the more quick, effective and efficient the patient's management could be.

Ultraviolet radiation (UV) contributes to a variety of skin diseases including inflammation, degenerative aging, and cancer. Historically, humans have been exposed to UV radiation mainly through occupational exposure; recreational UV exposure, however, has increased dramatically in recent years, because of outdoor leisure activities and to purposely tan for cosmetic purposes. Both UVB and UVA radiation have been shown to cause DNA damage and immunosuppression, the important forms of biological damage that lead to NMSC. Nonmelanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized which continues to grow at an alarming rate, becoming an occupational disease. Available treatments alternative to surgery include photodynamic therapy, electrochemotherapy, cryotherapy, ablative lasers, 5-fluorouracil, imiquimod, ingenol mebutate, and diclofenac. Among these, photodynamic therapy is a noninvasive technique with excellent cosmetic outcome and good curative results, when used in initial stages of skin cancers for superficial lesions. It is administered under numerous and significantly varied regimens and there are a wide range of cure rates reported, permitting treatment of large and multiple lesions with excellent cosmetic results. This is an overview of photodynamic applications especially for the treatment of NMSC, with a short focus on daylight modality.

ejd.2013.2016 Auteur(s) : Emanuele Miraglia emanuele.miraglia@hotmail.it, Bianca Visconti, Daniela Bianchini, Stefano Calvieri, Sandra Giustini Policlinico Umberto i Department of Dermatology Viale del policlinico 155 00100 Rome, Italy Dercum's disease or adiposis dolorosa (OMIM:103200) is an autosomal dominant disease with an incidence of about 1/200,000 [1], variable phenotypical expression and slight female predominance, characterized by multiple painful subcutaneous lipomas, most frequently [...]