Background:Difficult-to-treat depression (DTD) presents a substantial health care challenge, with around one-third of people diagnosed with a depressive episode in the UK finding that their symptoms persist following treatment. This study aimed to identify priority research questions (RQs) that could inform the development of new and improved treatments, interventions, and support for people with DTD.Methods:Using an adapted Child Health and Nutrition Research Initiative (CHNRI) method, this national prioritisation exercise engaged 60 leading researchers and health care professionals in the UK, as well as 25 wider stakeholders with relevant lived experience to produce a ranked list of priority RQs in DTD. The final list of 99 distinct RQs was independently scored by 42 individuals against a list of five criteria: answerability, effectiveness, impact on health, deliverability, and equity.Results:Highly ranked RQs covered a range of novel and existing treatments. The three highest scoring RQs included evaluation of psychological and pharmacological therapies (eg, behavioural activation, and augmentation therapies), as well as social interventions to reduce loneliness or increase support for people with DTD.Conclusions:This exercise identified and prioritised 99 RQs that could inform future research and funding decisions over the next five years. The results of this research could improve treatment and support for people affected by DTD. It also serves as an example of ways in which the CHNRI method can be adapted in a collaborative manner to provide a more active role for patients, carers, and health care professionals.

The requirement to install electronic power and control systems in high temperature environments has posed a challenge to the traditional limit of 125°C for high temperature exposure of electronics systems. The leap in operating temperature to above 200°C in combination with high pressures, vibrations and potentially corrosive environments means that different semiconductors, passives, circuit boards and assembly processes will be needed to fulfil the target performance specifications. The fundamental change to enable this step change in packaging performance to be implemented is to switch from the traditional soldered surface mount or through-hole packaged devices assembled onto FR4 printed circuit board materials to bare die mounted onto ceramic, insulated metal or polyimide based substrates with selected materials that are intrinsically more capable of withstanding the high temperatures without degradation for prolonged durations. Results of the evaluation of electronic interconnect materials and substrate technologies that have been submitted to temperatures of 250°C for up to 2000 hours will be presented; including novel adhesive formulations and insulated metal substrates. Phenomena such as thermal migration and material deterioration due to high temperature exposure in air and inert atmospheres will be described, backed up by non-destructive scanning acoustic microscopy (SAM) of samples assessed throughout the long term testing programme. This work forms part of the UPTEMP project has been set-up with support from UK Technology Strategy Board and the EPSRC, which started in March 2007 with 3 years duration. The project brings together a consortium of end-users (Sondex Wireline and Vibro-Meter UK), electronic module manufacturers (GE Aviation Systems Newmarket) and material suppliers (Gwent Electronic Materials and Thermastrate Ltd) with Oxford University - Materials Department, the leading UK high temperature electronics research centre.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Microwave dielectric heating methods for the preparation of a number of arsenate, phosphate, vanadate, molybdate and carbonate minerals and their deuterated analogues are reported; rapid and efficient syntheses of these have been achieved. The application of this to the study of vibrational spectroscopy of minerals is discussed, with particular reference to scorodite.

The high yield and rapid precipitation of iron(iii) arsenate(v) dihydrate (identical to the mineral scorodite) from aqueous iron(iir)-arsenic(v) solutions in the pH range 0.6-1.1 has been achieved using microwave dielectric heating; the results have significant implications for the removal of arsenic from industrial wastes.

Reaction of cis-Pt(PMe2Ph)2Cl2 with Tl2[7-Ph-7,8-nido-C2B9H10] affords 1-Ph-3,3-(PMe2Ph)2-3,1,2-PtC2B9H10, mild thermolysis (55°C) of which yields 1-Ph-3,3-(PMe2Ph)2-3,1,11-PtC2B9H10 and 11-Ph-3,3-(PMe2Ph)2-3,1,11-PtC2B9H10. Both of the latter compounds are produced by the microwave irradiation of a mixture of cis-Pt(PMe2Ph)2Cl2 and [HNMe3][7-Ph-7,8-nido-C2B9H11]. When cis-Pt(PMe2Ph)2Cl2 is allowed to react with Tl2[7,8-Ph2-7,8-nido-C2B9H9] at room temperature the only isolable species is 1,11-Ph2-3,3-(PMe2Ph)2-3,1,11-PtC2B9H9. The generation of rearranged products with 3,1,11-PtC2B9 architectures is inconsistent with a diamond-square-diamond mechanism for the isomerisation of icosahedral heteroboranes.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Fluoroptic temperature measurements have established that organic solvents in a microwave cavity superheat by 13-26-degrees-C above their conventional boiling points at atmospheric pressure; this behaviour is interpreted using a model of nucleate boiling that emphasises the importance of the wetting properties of the solvents.

Using a thick-walled glass reaction vessel a number of transition-metal organometallic and co-ordination compounds have been synthesised using microwave dielectric super-heating effects. Super-heating by 40-60-degrees-C is maintained by controlling the pressure at 10 atm and results in a decrease in the reaction time required for conventional reflux reactions by a factor of ca. 10(2). Full details of the design of the apparatus, the modification of a conventional microwave oven and the electrical circuitry for the pressure control are

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInformVolume 19, Issue 46 Physical Inorganic Chemistry ChemInform Abstract: Application of Microwave Heating Techniques for the Synthesis of Solid State Inorganic Compounds. D. R. BAGHURST, D. R. BAGHURST Inorg. Chem. Lab., Oxford Univ., Oxford OX1 3QR, UKSearch for more papers by this authorD. M. P. MINGOS, D. M. P. MINGOS Inorg. Chem. Lab., Oxford Univ., Oxford OX1 3QR, UKSearch for more papers by this author D. R. BAGHURST, D. R. BAGHURST Inorg. Chem. Lab., Oxford Univ., Oxford OX1 3QR, UKSearch for more papers by this authorD. M. P. MINGOS, D. M. P. MINGOS Inorg. Chem. Lab., Oxford Univ., Oxford OX1 3QR, UKSearch for more papers by this author First published: November 15, 1988 https://doi.org/10.1002/chin.198846033AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume19, Issue46November 15, 1988 RelatedInformation