Mixed hematopoietic chimerism is proven to lead to immune tolerance after bone marrow transplant (BMT) and can reduce graft-vs-host disease (GVHD)-related mortality. It can be achieved with chemotherapeutic agents or strategies that block activation of donor or depletion of host T cells. Immune conditioning with helminthic commensals regulate the host immune system and promotes a transient mixed chimerism. Conditioning with helminths induces IL4 production via host Th2 pathway and regulates GVHD while preserving graft-versus-tumor effect. IL4 signals through IL4 receptor (IL4R) and STAT6. We hypothesize that induction of host Th2 pathway is critical for achieving mixed chimerism by intestinal immune conditioning
Xiaoqun Guan合作论文数2
Bruce Blazar合作论文数Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, Department of Pediatrics, Medical School, University of Minnesota;Center for Translational Medicine, University of Minnesota2
M. Nedim Ince合作论文数2Tyler Atagozli合作论文数1Jamie Truscott合作论文数1Sonay Beyatli合作论文数1Hope Fury合作论文数1Ahmed Metwali合作论文数1
